Β-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast

Journal of Pathology

Volumn 200, Issue 5, 2003, Pages 627-632

  Sawyer, Elinor J ^a   Hanby, Andrew M ^b   Poulsom, Richard ^a   Jeffery, Rosemary ^a   Gillett, Cheryl E ^c   Ellis, Ian O ^d   Ellis, Paul ^c   Tomlinson, Ian P M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

^d NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

catenin; Fibroadenomas; IGF I; IGF II; Immunohistochemistry; In situ hybridization; Phyllodes tumours; Wnt2; Wnt5a

Indexed keywords

BETA CATENIN; SOMATOMEDIN B; SOMATOMEDIN C;

ARTICLE; BREAST FIBROADENOMA; BREAST FIBROMA; CELL NUCLEUS; CONTROLLED STUDY; CORRELATION FUNCTION; CYSTOSARCOMA PHYLLOIDES; DATA ANALYSIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA CELL;

BETA CATENIN; BREAST NEOPLASMS; CELL NUCLEUS; CYTOSKELETAL PROTEINS; FEMALE; FIBROADENOMA; HUMANS; IMMUNOENZYME TECHNIQUES; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; NEOPLASM PROTEINS; PHYLLODES TUMOR; SOMATOMEDINS; TRANS-ACTIVATORS;

EID: 0042524213     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1391     Document Type: Article

References (12)

1. Sawyer EJ, Hanby AM, Rowan AJ, et al. The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours. J Pathol 2002; 196: 437-444.
2. Yee D, Paik S, Lebovic GS, et al. Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol 1989; 3: 509-517.
3. Yee D, Cullen KJ, Paik S, et al. Insulin-like growth factor II mRNA expression in human breast cancer. Cancer Res 1988; 48: 6691-6696.
4. Playford MP, Bicknell D, Bodmer WF, Macaulay VM. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci U S A 2000; 97: 12 103-12 108.
5. Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoel MJ, et al. Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene 2001; 20: 252-259.
6. Morali OG, Delmas V, Moore R, Jeanney C, Thiery JP, Larue L. IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene 2001; 20: 4942-4950.
7. Zandvliet DW, Hanby AM, Austin CA, et al. Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation. Biochim Biophys Acta 1996; 1307: 239-247.
8. Singer C, Rasmussen A, Smith HS, Lippman ME, Lynch HT, Cullen KJ. Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function. Cancer Res 1995; 55: 2448-2454.
9. Hadsell DL, Bonnette SG. IGF and insulin action in the mammary gland: lessons from transgenic and knockout models. J Mammary Gland Biol Neoplasia 2000; 5: 19-30.
10. Vu TH, Yballe C, Boonyanit S, Hoffman AR. Insulin-like growth factor II in uterine smooth-muscle tumors: maintenance of genomic imprinting in leiomyomata and loss of imprinting in leiomyosarcomata. J Clin Endocrinol Metab 1995; 80: 1670-1676.
11. Baserga R. The contradictions of the insulin-like growth factor 1 receptor. Oncogene 2000; 19: 5574-5581.
12. Oates AJ, Schumaker LM, Jenkins SB, et al. The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene. Breast Cancer Res Treat 1998; 47: 269-281.