메뉴 건너뛰기




Volumn 8, Issue 5, 2007, Pages 345-353

Insulin resistance is affected by increased levels of plasma lactate but not mitochondrial alterations in skeletal muscle in NRTI-exposed HIV-infected patients

Author keywords

HIV 1 infection; Insulin resistance; Lactate; Mitochondrial dysfunction

Indexed keywords

ABACAVIR; CELL NUCLEUS DNA; DIDANOSINE; EFAVIRENZ; INDINAVIR; LACTIC ACID; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; MITOCHONDRIAL DNA; NEVIRAPINE; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR DISOPROXIL; ZALCITABINE; ZIDOVUDINE;

EID: 36049042606     PISSN: 15284336     EISSN: None     Source Type: Journal    
DOI: 10.1310/hct0805-345     Document Type: Article
Times cited : (8)

References (43)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338(13):853-860.
    • (1998) N Engl J Med , vol.338 , Issue.13 , pp. 853-860
    • Palella Jr, F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 2
    • 0033604038 scopus 로고    scopus 로고
    • Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [see comment]
    • Brinkman K, Smeitink JA, Romijn JA, Reiss P. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [see comment]. Lancet. 1999;354(9184):1112-1115.
    • (1999) Lancet , vol.354 , Issue.9184 , pp. 1112-1115
    • Brinkman, K.1    Smeitink, J.A.2    Romijn, J.A.3    Reiss, P.4
  • 3
    • 1342310769 scopus 로고    scopus 로고
    • Antiretroviral nucleoside and nucleotide analogues and mitochondria [review]
    • Cossarizza A, Moyle G. Antiretroviral nucleoside and nucleotide analogues and mitochondria [review]. AIDS. 2004;18(2):137-151.
    • (2004) AIDS , vol.18 , Issue.2 , pp. 137-151
    • Cossarizza, A.1    Moyle, G.2
  • 4
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with Type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman Gl. Impaired mitochondrial activity in the insulin-resistant offspring of patients with Type 2 diabetes. N Engl J Med. 2004;350(7):664-671.
    • (2004) N Engl J Med , vol.350 , Issue.7 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.5
  • 5
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes. 2002;51(10):2944- 2950.
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 6
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1 alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, et al. PGC-1 alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34(3):267-273.
    • (2003) Nat Genet , vol.34 , Issue.3 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 7
    • 0028990381 scopus 로고
    • Mitochondrial toxicity of antiviral drugs
    • Lewis W, Dalakas MC. Mitochondrial toxicity of antiviral drugs. Nat Med. 1995; 1(5):417-422.
    • (1995) Nat Med , vol.1 , Issue.5 , pp. 417-422
    • Lewis, W.1    Dalakas, M.C.2
  • 8
    • 0028148674 scopus 로고
    • Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
    • Martin JL, Brown CE, Matthews-Davis N, Reardon JE. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrobial Agents Chemother. 1994;38(12):2743-2749.
    • (1994) Antimicrobial Agents Chemother , vol.38 , Issue.12 , pp. 2743-2749
    • Martin, J.L.1    Brown, C.E.2    Matthews-Davis, N.3    Reardon, J.E.4
  • 9
    • 0037076029 scopus 로고    scopus 로고
    • Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients
    • Cote HC, Brumme ZL, Craib KJ, et al. Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients. N Engl J Med. 2002;346(11):811-820.
    • (2002) N Engl J Med , vol.346 , Issue.11 , pp. 811-820
    • Cote, H.C.1    Brumme, Z.L.2    Craib, K.J.3
  • 10
    • 20844435624 scopus 로고    scopus 로고
    • In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA
    • Mallon PW, Unemori P, Sedwell R, et al. In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA. J Infect Dis. 2005;191(10):1686-1696.
    • (2005) J Infect Dis , vol.191 , Issue.10 , pp. 1686-1696
    • Mallon, P.W.1    Unemori, P.2    Sedwell, R.3
  • 11
    • 34047212195 scopus 로고    scopus 로고
    • Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to zidovudine
    • Divi RL, Haverkos KJ, Humsi JA, et al. Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to zidovudine. Environ Mol Mutagen. 2007;48(3-4):179-189.
    • (2007) Environ Mol Mutagen , vol.48 , Issue.3-4 , pp. 179-189
    • Divi, R.L.1    Haverkos, K.J.2    Humsi, J.A.3
  • 12
    • 33745913329 scopus 로고    scopus 로고
    • Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individuals
    • Cherry CL, Nolan D, James IR, et al. Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individuals. J Acquir Immune Defic Syndr. 2006;42(4):435-440.
    • (2006) J Acquir Immune Defic Syndr , vol.42 , Issue.4 , pp. 435-440
    • Cherry, C.L.1    Nolan, D.2    James, I.R.3
  • 13
    • 0346333250 scopus 로고    scopus 로고
    • Contribution of nucleoside-analogue reverse transcriptase inhibitor therapy to lipoatrophy from the population to the cellular level
    • Nolan D, Hammond E, James I, McKinnon E, Mallal S. Contribution of nucleoside-analogue reverse transcriptase inhibitor therapy to lipoatrophy from the population to the cellular level. Antiviral Ther. 2003;8:617-626.
    • (2003) Antiviral Ther , vol.8 , pp. 617-626
    • Nolan, D.1    Hammond, E.2    James, I.3    McKinnon, E.4    Mallal, S.5
  • 14
    • 0032493043 scopus 로고    scopus 로고
    • A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors
    • Carr A, Samaras K, Burton S, et al. A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors. AIDS. 1998;12(7):F51-F58.
    • (1998) AIDS , vol.12 , Issue.7
    • Carr, A.1    Samaras, K.2    Burton, S.3
  • 15
    • 15444374792 scopus 로고    scopus 로고
    • Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS
    • Levy AR, McCandless L, Harrigan PR, et al. Changes in lipids over twelve months after initiating protease inhibitor therapy among persons treated for HIV/AIDS. Lipids Health Dis. 2005;4(1):4.
    • (2005) Lipids Health Dis , vol.4 , Issue.1 , pp. 4
    • Levy, A.R.1    McCandless, L.2    Harrigan, P.R.3
  • 16
    • 0032533536 scopus 로고    scopus 로고
    • Impaired glucose tolerance and protease inhibitors
    • Walli R, Goebel FD, Demant T. Impaired glucose tolerance and protease inhibitors. Ann Intern Med. 1998;129(10):837-838.
    • (1998) Ann Intern Med , vol.129 , Issue.10 , pp. 837-838
    • Walli, R.1    Goebel, F.D.2    Demant, T.3
  • 17
    • 0037066357 scopus 로고    scopus 로고
    • Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations
    • Murata H, Hruz PW, Mueckler M. Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations. AIDS. 2002;16(6):859-863.
    • (2002) AIDS , vol.16 , Issue.6 , pp. 859-863
    • Murata, H.1    Hruz, P.W.2    Mueckler, M.3
  • 18
    • 0037192590 scopus 로고    scopus 로고
    • Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: A randomized, placebo-controlled study
    • Noor MA, Seneviratne T, Aweeka FT, et al. Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study. AIDS. 2002;16(5):F1-F8.
    • (2002) AIDS , vol.16 , Issue.5
    • Noor, M.A.1    Seneviratne, T.2    Aweeka, F.T.3
  • 19
    • 0034492351 scopus 로고    scopus 로고
    • Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy
    • Mynarcik DC, McNurlan MA, Steigbigel RT, Fuhrer J, Gelato MC. Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy. J Acquir Immune Defic Syndr. 2000;25(4):312-321.
    • (2000) J Acquir Immune Defic Syndr , vol.25 , Issue.4 , pp. 312-321
    • Mynarcik, D.C.1    McNurlan, M.A.2    Steigbigel, R.T.3    Fuhrer, J.4    Gelato, M.C.5
  • 20
    • 0037323424 scopus 로고    scopus 로고
    • Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy
    • Addy CL, Gavrila A, Tsiodras S, Brodovicz K, Karchmer AW, Mantzoros CS. Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J Clin Endocrinol Metab. 2003;88(2):627-636.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.2 , pp. 627-636
    • Addy, C.L.1    Gavrila, A.2    Tsiodras, S.3    Brodovicz, K.4    Karchmer, A.W.5    Mantzoros, C.S.6
  • 21
    • 14544281531 scopus 로고    scopus 로고
    • HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo
    • Lagathu C, Kim M, Maachi M, et al. HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo. Biochimie. 2005;87(1):65-71.
    • (2005) Biochimie , vol.87 , Issue.1 , pp. 65-71
    • Lagathu, C.1    Kim, M.2    Maachi, M.3
  • 22
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7(8):941-946.
    • (2001) Nat Med , vol.7 , Issue.8 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 23
    • 34250648975 scopus 로고    scopus 로고
    • Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults
    • Epub Feb 6
    • Fleischman A, Johnsen S, Systrom DM, et al. Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults. Am J Physiol Endocrinol Metab. 2007;292(6):E1666-1673. Epub Feb 6, 2007.
    • (2007) Am J Physiol Endocrinol Metab. 2007 , vol.292 , Issue.6
    • Fleischman, A.1    Johnsen, S.2    Systrom, D.M.3
  • 24
    • 27444431816 scopus 로고    scopus 로고
    • Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study
    • Brown TT, Li X, Cole SR, et al. Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study. AIDS. 2005;19(13):1375- 1383.
    • (2005) AIDS , vol.19 , Issue.13 , pp. 1375-1383
    • Brown, T.T.1    Li, X.2    Cole, S.R.3
  • 25
    • 0842330339 scopus 로고    scopus 로고
    • Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients
    • Lindegaard B, Keller P, Bruunsgaard H, Gerstoft J, Pedersen BK. Low plasma level of adiponectin is associated with stavudine treatment and lipodystrophy in HIV-infected patients. Clin Exp Immunol. 2004;135(2):273-279.
    • (2004) Clin Exp Immunol , vol.135 , Issue.2 , pp. 273-279
    • Lindegaard, B.1    Keller, P.2    Bruunsgaard, H.3    Gerstoft, J.4    Pedersen, B.K.5
  • 26
    • 23044453130 scopus 로고    scopus 로고
    • Depleted skeletal muscle mitochondrial DNA, hyperlactatemia, and decreased oxidative capacity in HIV-infected patients on highly active antiretroviral therapy
    • Haugaard SB, Andersen O, Pedersen SB, et al. Depleted skeletal muscle mitochondrial DNA, hyperlactatemia, and decreased oxidative capacity in HIV-infected patients on highly active antiretroviral therapy. J Med Virol. 2005;77:29-38.
    • (2005) J Med Virol , vol.77 , pp. 29-38
    • Haugaard, S.B.1    Andersen, O.2    Pedersen, S.B.3
  • 27
    • 27444436170 scopus 로고    scopus 로고
    • The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infection
    • Lo JC, Kazemi MR, Hsue PY, et al. The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infection. Clin Infect Dis. 2005;41:1335-1340.
    • (2005) Clin Infect Dis , vol.41 , pp. 1335-1340
    • JC, L.1    Kazemi, M.R.2    Hsue, P.Y.3
  • 28
    • 2442604588 scopus 로고    scopus 로고
    • Body composition changes in 308 Norwegian HIV-positive patients
    • Bergersen BM, Sandvik L, Bruun JN. Body composition changes in 308 Norwegian HIV-positive patients. Scand J Infect Dis. 2004;36(3):186-191.
    • (2004) Scand J Infect Dis , vol.36 , Issue.3 , pp. 186-191
    • Bergersen, B.M.1    Sandvik, L.2    Bruun, J.N.3
  • 30
    • 0028062156 scopus 로고
    • Hyperproinsulinemia of type II diabetes is not present before the development of hyperglycemia
    • Birkeland KI, Torjesen PA, Eriksson J, Vaaler S, Groop L. Hyperproinsulinemia of type II diabetes is not present before the development of hyperglycemia. Diabetes Care. 1994;17(11):1307-1310.
    • (1994) Diabetes Care , vol.17 , Issue.11 , pp. 1307-1310
    • Birkeland, K.I.1    Torjesen, P.A.2    Eriksson, J.3    Vaaler, S.4    Groop, L.5
  • 31
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419.
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 32
    • 0024461242 scopus 로고
    • Screening for mitochondrial cytopathies: The sub-anaerobic threshold exercise test (SATET)
    • Nashef L, Lane RJ. Screening for mitochondrial cytopathies: the sub-anaerobic threshold exercise test (SATET). J Neurol Neurosurg Psychiatry. 1989;52(9):1090-1094.
    • (1989) J Neurol Neurosurg Psychiatry , vol.52 , Issue.9 , pp. 1090-1094
    • Nashef, L.1    Lane, R.J.2
  • 33
    • 0018757774 scopus 로고
    • Determination of anaerobic threshold by the ventilation equivalent in normal individuals
    • Reinhard U, Muller PH, Schmulling R-M. Determination of anaerobic threshold by the ventilation equivalent in normal individuals. Respiration. 1979;38:36-42.
    • (1979) Respiration , vol.38 , pp. 36-42
    • Reinhard, U.1    Muller, P.H.2    Schmulling, R.-M.3
  • 34
    • 33748103186 scopus 로고    scopus 로고
    • Mitochondrial (mt) DNA changes in tissue may not be reflected by depletion of mtDNA in peripheral blood mononuclear cells in HIV-infected patients
    • Maagaard A, Holberg-Petersen M, Kollberg G, Oldfors A, Sandvik L, Bruun JN. Mitochondrial (mt) DNA changes in tissue may not be reflected by depletion of mtDNA in peripheral blood mononuclear cells in HIV-infected patients. Antiviral Ther. 2006;11:601-608.
    • (2006) Antiviral Ther , vol.11 , pp. 601-608
    • Maagaard, A.1    Holberg-Petersen, M.2    Kollberg, G.3    Oldfors, A.4    Sandvik, L.5    Bruun, J.N.6
  • 35
    • 0036320908 scopus 로고    scopus 로고
    • Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling
    • Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002;283(2):E233-E240.
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , Issue.2
    • Choi, C.S.1    Kim, Y.B.2    Lee, F.N.3    Zabolotny, J.M.4    Kahn, B.B.5    Youn, J.H.6
  • 36
    • 33947172448 scopus 로고    scopus 로고
    • Lactate release from adipose tissue and skeletal muscle in vivo: Defective insulin regulation in insulin-resistant obese women
    • Qvisth V, Hagstrom-Toft E, Moberg E, Sjoberg S, Bolinder J. Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women. Am J Physiol Endocrinol Metab. 2007;292(3):E709-E714.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , Issue.3
    • Qvisth, V.1    Hagstrom-Toft, E.2    Moberg, E.3    Sjoberg, S.4    Bolinder, J.5
  • 37
    • 0035491322 scopus 로고    scopus 로고
    • Increased lactate release per fat cell in normoglycemic first-degree relatives of individuals with type 2 diabetes
    • Sandqvist MM, Eriksson JW, Jansson PA. Increased lactate release per fat cell in normoglycemic first-degree relatives of individuals with type 2 diabetes. Diabetes. 2001;50(10):2344-2348.
    • (2001) Diabetes , vol.50 , Issue.10 , pp. 2344-2348
    • Sandqvist, M.M.1    Eriksson, J.W.2    Jansson, P.A.3
  • 38
    • 0035964717 scopus 로고    scopus 로고
    • Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy
    • Shikuma CM, Hu N, Milne C, et al. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy. AIDS. 2001;15(14):1801-1809.
    • (2001) AIDS , vol.15 , Issue.14 , pp. 1801-1809
    • Shikuma, C.M.1    Hu, N.2    Milne, C.3
  • 39
    • 0036471555 scopus 로고    scopus 로고
    • Evidence of nucleoside analogue reverse transcriptase inhibitor - associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients
    • Walker UA, Bickel M, Lutke Volksbeck SI, et al. Evidence of nucleoside analogue reverse transcriptase inhibitor - associated genetic and structural defects of mitochondria in adipose tissue of HIV-infected patients. J Acquir Immune Defic Syndr. 2002;29(2):117-121.
    • (2002) J Acquir Immune Defic Syndr , vol.29 , Issue.2 , pp. 117-121
    • Walker, U.A.1    Bickel, M.2    Lutke Volksbeck, S.I.3
  • 40
    • 33749041269 scopus 로고    scopus 로고
    • Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance
    • Wredenberg A, Freyer C, Sandstrom ME, et al. Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance. Biochem Biophys Res Commun. 2006;350(1):202-207.
    • (2006) Biochem Biophys Res Commun , vol.350 , Issue.1 , pp. 202-207
    • Wredenberg, A.1    Freyer, C.2    Sandstrom, M.E.3
  • 41
    • 0037013087 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial function and exercise capacity in HIV-infected patients with lipodystrophy and elevated p-lactate levels
    • Roge BT, Calbet JAL, Moller K, et al. Skeletal muscle mitochondrial function and exercise capacity in HIV-infected patients with lipodystrophy and elevated p-lactate levels. AIDS. 2002;16(7):973-982.
    • (2002) AIDS , vol.16 , Issue.7 , pp. 973-982
    • Roge, B.T.1    Calbet, J.A.L.2    Moller, K.3
  • 42
    • 33847773805 scopus 로고    scopus 로고
    • Limitation of exercise capacity in nucleoside-treated HIV-infected patients with hyperlactataemia
    • Duong M, Dumas JP, Buisson M, et al. Limitation of exercise capacity in nucleoside-treated HIV-infected patients with hyperlactataemia. HIV Med. 2007;8(2):105-111.
    • (2007) HIV Med , vol.8 , Issue.2 , pp. 105-111
    • Duong, M.1    Dumas, J.P.2    Buisson, M.3
  • 43
    • 32044434450 scopus 로고    scopus 로고
    • Noninvasive diagnosis of mitochondrial dysfunction in HAART-related hyperlactatemia
    • Garrabou G, Sanjurjo E, Miro O, et al. Noninvasive diagnosis of mitochondrial dysfunction in HAART-related hyperlactatemia. Clin Infect Dis. 2006;42(4):584-585.
    • (2006) Clin Infect Dis , vol.42 , Issue.4 , pp. 584-585
    • Garrabou, G.1    Sanjurjo, E.2    Miro, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.