Elevated iron status strongly predicts mortality in west African adults with HIV infection

Journal of Acquired Immune Deficiency Syndromes

Volumn 46, Issue 4, 2007, Pages 498-507

  McDermid, Joann M ^a   Jaye, Assan ^b   Schim Van Der Loeff, Maarten F ^b   Todd, Jim ^c   Bates, Chris ^a   Austin, Steve ^a   Jeffries, David ^b   Awasana, Akum A ^b   Whittle, Hilton C ^b   Prentice, Andrew M ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Africa; Cohort; Iron; Mortality; Nutrition

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; FERRITIN; HEMOGLOBIN; IRON; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ADULT; AFRICAN AMERICAN; AGE; ARTICLE; BODY MASS; CD4 LYMPHOCYTE COUNT; CONFIDENCE INTERVAL; ETHNICITY; FEMALE; HAZARD RATIO; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IRON BALANCE; MALARIA; MALE; MORTALITY; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; SEROPREVALENCE; SEX DIFFERENCE;

ADOLESCENT; ADULT; COHORT STUDIES; DEMOGRAPHY; ETHNIC GROUPS; FEMALE; GAMBIA; HIV INFECTIONS; HUMANS; IRON; MALE; QUESTIONNAIRES; SURVIVAL ANALYSIS;

EID: 36049038530     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e31815b2d4b     Document Type: Article

References (40)

1. McDermid JM, Prentice AM. Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV. Clin Sci (Lond). 2006;110:503-524.
2. Sullivan PS, Hanson DL, Chu SY, et al. Epidemiology of anemia in human immunodeficiency virus (HIV)-infected persons: results from the multistate adult and adolescent spectrum of HIV disease surveillance project. Blood. 1998;91:301-308.
3. Moore RD. Human immunodeficiency virus infection, anemia, and survival. Clin Infect Dis. 1999;29:44-49.
4. Mocroft A, Kirk O, Barton SE, et al. Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. EuroSIDA study group. AIDS. 1999;13:943-950.
5. Gordeuk VR, Delanghe JR, Langlois MR, et al. Iron status and the outcome of HIV infection: an overview. J Clin Virol. 2001;20:111-115.
6. Gordeuk VR, Onojobi G, Schneider MF, et al. The association of serum ferritin and transferrin receptor concentrations with mortality in women with human immunodeficiency virus infection. Haematologica. 2006;91:739-743.
7. Balakrishnan P, Solomon S, Kumarasamy N, et al. Low-cost monitoring of HIV infected individuals on highly active antiretroviral therapy (HAART) in developing countries. Indian J Med Res. 2005;121:345-355.
8. Tucker T, Yeats J. Laboratory monitoring of HIV - after access to antiretroviral drugs, the next challenge for the developing world. S Afr Med J. 2001;91:615.
9. Stephenson J. Cheaper HIV drugs for poor nations bring a new challenge: monitoring treatment. JAMA. 2002;288:151-153.
10. Schim van der Loeff MF, Jaffar S, Aveika AA, et al. Mortality of HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients in a clinic-based cohort in The Gambia. AIDS. 2002;16:1775-1783.
11. Hill AV, Allsopp CE, Kwiatkowski D, et al. Common west African HLA antigens are associated with protection from severe malaria. Nature. 1991;352:595-600.
12. Milman N, Thomsen H, Mathiassen B. Serum ferritin, iron status and plasma ascorbic acid in 40- to 49-year- old males in the Faroe Islands. Scand J Clin Lab Invest. 1990;50:559-564.
13. Malope BI, MacPhail AP, Alberts M, et al. The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status. Br J Haematol. 2001;115:84-89.
14. Mainous AG 3rd, Gill JM, Carek PJ. Elevated serum transferrin saturation and mortality. Ann Fam Med. 2004;2:133-138.
15. Mainous AG 3rd, Wells B, Carek PJ, et al. The mortality risk of elevated serum transferrin saturation and consumption of dietary iron. Ann Fam Med. 2004;2:139-144.
16. Khumalo H, Gomo ZA, Moyo VM, et al. Serum transferrin receptors are decreased in the presence of iron overload. Clin Chem. 1998;44:40-44.
17. Gibson RS. Principles of Nutritional Assessment. New York: Oxford University Press; 1990.
18. Allen J, Backstrom KR, Cooper JA, et al. Measurement of soluble transferrin receptor in serum of healthy adults. Clin Chem. 1998;44:35-39.
19. Fields-Gardner C, Thomson CA, Rhodes SS. A Clinician's Guide to Nutrition in HIV and AIDS. Chicago: The American Dietetic Association; 1997.
20. van der Sande MA, Schim van der Loeff MF, Aveika AA, et al. Body mass index at time of HIV diagnosis: a strong and independent predictor of survival. J Acquir Immune Defic Syndr. 2004;37:1288-1294.
21. Gomo E, Vennervald BJ, Ndhlovu PD, et al. Reference values and predictors of white blood cell subset counts: a cross-sectional study among HIV seronegative pregnant women in Zimbabwe. Eur J Obstet Gynecol Reprod Biol. 2003;107:156-162.
22. Sullivan P. Associations of anemia, treatments for anemia, and survival in patients with human immunodeficiency virus infection. J Infect Dis. 2002;185(Suppl 2):S138-S142.
23. Salhi Y, Costagliola D, Rebulla P, et al. Serum ferritin, desferrioxamine, and evolution of HIV-1 infection in thalassemic patients. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;18:473-478.
24. de Monye C, Karcher DS, Boelaert JR, et al. Bone marrow macrophage iron grade and survival of HIV-seropositive patients. AIDS. 1999;13:375-380.
25. Salmon-Ceron D, Fontbonne A, Saba J, et al. Lower survival in AIDS patients receiving dapsone compared with aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia. J Infect Dis. 1995;172:656-664.
26. Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta. 2003;329:9-22.
27. Cook JD. The measurement of serum transferrin receptor. Am J Med Sci. 1999;318:269-276.
28. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89:1052-1057.
29. Halonen P, Mattila J, Suominen P, et al. Iron overload in children who are treated for acute lymphoblastic leukemia estimated by liver siderosis and serum iron parameters. Pediatrics. 2003;111:91-96.
30. Worwood M. Serum transferrin receptor assays and their application. Ann Clin Biochem. 2002;39:221-230.
31. Beck MA, Nelson HK, Shi Q, et al. Selenium deficiency increases the pathology of an influenza virus infection. FASEB J. 2001;15:1481-1483.
32. Lounis N, Truffot-Pernot C, Grosset J, et al. Iron and Mycobacterium tuberculosis infection. J Clin Virol. 2001;20:123-126.
33. Douvas GS, May MH, Crowle AJ. Transferrin, iron, and serum lipids enhance or inhibit Mycobacterium avium replication in human macrophages. J Infect Dis. 1993;167:857-864.
34. Offermann MK, Lin JC, Mar EC, et al. Antioxidant-sensitive regulation of inflammatory-response genes in Kaposi's sarcoma cells. J Acquir Immune Defic Syndr Hum Retrovirol. 1996;13:1-11.
35. Simonart T, Noel JC, Andrei G, et al. Iron as a potential co-factor in the pathogenesis of Kaposi's sarcoma? Int J Cancer. 1998;78:720-726.
36. Olsen A, Mwaniki D, Krarup H, et al. Low-dose iron supplementation does not increase HIV-1 load. J Acquir Immune Defic Syndr. 2004;36:637-638.
37. Semba R, Ricketts E, Mehta S, et al. Effect of micronutrients and iron supplementation on hemoglobin, iron status, and plasma hepatitis C and HIV RNA levels in female injection drug users: a controlled clinical trial. J Acquir Immune Defic Syndr. 2007;45:298-303.
38. Semba RD, Shah N, Strathdee SA, et al. High prevalence of iron deficiency and anemia among female injection drug users with and without HIV infection. J Acquir Immune Defic Syndr. 2002;29:142-144.
39. Traore HN, Meyer D. The effect of iron overload on in vitro HIV-1 infection. J Clin Virol. 2004;31(Suppl 1):S92-S98.
40. Moore RD, Keruly JC, Chaisson RE. Anemia and survival in HIV infection. J Acquir Immune Defic Syndr Hum Retrovirol. 1998;19:29-33.