Serum transferrin receptors are decreased in the presence of iron overload

Clinical Chemistry

Volumn 44, Issue 1, 1998, Pages 40-44

  Khumalo, Hlosukwazi ^a   Gomo, Zvenyika A R ^a   Moyo, Victor M ^a   Gordeuk, Victor R ^c   Saungweme, Thokozile ^a   Rouault, Tracey A ^b   Gangaidzo, Innocent T ^a  

^a UNIV OF ZIMBABWE MEDICAL SCHOOL   (Zimbabwe)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; FERRITIN; TRANSFERRIN RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; HUMAN; HUMAN CELL; HUMAN TISSUE; IRON BLOOD LEVEL; IRON OVERLOAD; IRON STORAGE; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; QUANTITATIVE DIAGNOSIS; RECEPTOR BINDING; SCHOOL CHILD; TRANSFERRIN BLOOD LEVEL;

EID: 0031962391     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/44.1.40     Document Type: Article

References (41)

1. Finch C. Regulation of iron balance in humans. Blood 1994;84: 1697-702.
2. Kohgo Y, Niitsu Y, Kondo H, Kato J, Tsushima N, Sasaki K, Urushizaki I. Serum transferrin receptors as a new index of erythropoiesis. Blood 1987;70:1955-8.
3. Kohgo Y, Niitsu Y, Nishisato T, Kato J, Kondo H, Sasaki K, Urushizaki I. Quantitation and characterisation of serum transferrin receptor in patients with anemias and polycythemias. Jpn J Med 1988;27:64-70.
4. Skikne BS, Cook JD. Serum transferrin receptors: quantitative measure of tissue iron deficiency. Blood 1990;75:1870-6.
5. Flowers CH, Skikne BS, Covell AM, Cook JD. Clinical measurement of serum transferrin receptors. J Lab Clin Med 1989;114: 368-77.
6. Heubers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 1990;75:102-7.
7. Baynes RD, Cook JD, Bothwell TH, Friedman BM, Meyer TE. Serum transferrin receptors in hereditary hemochromatosis and African siderosis. Am J Hematol 1994;45:288-92.
8. Thorstensen K, Romslo I. Measurement of serum transferrin receptors in screening for hemochromatosis [Letter]. Clin Chem 1992;38:1510.
9. Ledue TB, Craig WY. Serum concentrations of transferrin receptor in hereditary hemochromatosis [Letter]. Clin Chem 1995;41: 1053-4.
10. Centis F, Delfini C, Agostinelli F, Barbanti I, Annibali M, Lucarelli G. Correlation between soluble transferrin receptor and serum ferritin levels following bone marrow transplantation for thalassemia. Eur J Haematol 1995;54:329-33.
11. Turkewitz AP, Amatruda JF, Borhani D, Harrison SC, Schwartz AL. A high yield purification of the human transferrin receptor and properties of its major extracellular fragment. J Biol Chem 1988;263:8318-25.
12. Klausner RD, Rouault TA, Harford JB. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 1993;72:19-28.
13. Hentze MW, Kuhn LC. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A 1996;93:8175-82.
14. Haile DJ, Rouault TA, Tang CK, Chin J, Harford JB, Klausner RD. Reciprocal control of RNA binding and aconitase activity in the regulation of iron responsive element binding protein: role of iron sulfur cluster. Proc Natl Acad Sci U S A 1992;89:7536-40.
15. Rouault TA, Rao K, Harford J, Mattia E, Klausner RD. Hemin, chelatable iron, and the regulation of transferrin receptor biosynthesis. J Biol Chem 1985;260:14862-6.
16. Rouault TA, Hentze MW, Caughman SW, Harford BJ, Klausner RD. Binding of a cytosolic protein to the iron responsive element of human ferritin messenger RNA. Science 1988;241:1207-10.
17. Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, Klausner RD. Identification of the iron responsive element for the transcriptional regulation of human ferritin mRNA. Science 1987;238:1570-3.
18. Casey JL, Koeller DM, Ramin VC, Klausner RD, Harford JB. Iron regulation of transferrin receptor mRNA requires iron responsive elements and a rapid turnover of determinants in the 3′ untranslated region of the mRNA. EMBO J 1989;8:3693-9.
19. Haile DJ, Rouault TA, Harford JB, Kennedy MC, Blondin GA, Beinert H, Klausner RD. Cellular regulation of the iron responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high affinity RNA binding. Proc Natl Acad Sci U S A 1992;89:11735-9.
20. Bridges KR, Cudkowicz A. Effect of iron chelators on transferrin receptors in K562 cells. J Biol Chem 1984;259:12970-7.
21. Baynes RD, Shih YJ, Cook JD. Production of soluble transferrin receptor in K562 erythroleukaemia cells. Br J Haematol 1991; 78:450-5.
22. Lombard M, Bomford A, Hynes M, Naoumov NV, Roberts S, Crowe J, Williams R. Regulation of hepatic transferrin receptor in hemochromatosis. Hepatology 1989;9:1-5.
23. De Vos R, Sciot R, van Eyken P, Desmet VJ. Immunoelectron microscopic localization of hepatic transferrin receptors in human liver with and without iron overload. Virchows Arch B 1988;55:11-7.
24. Ward JH, Kushner JP, Ray FA, Kaplan J. Transferrin receptor function in hereditary hemochromatosis. J Clin Med 103:246-54.
25. Gordeuk VR, Mukiibi J, Hasstedt SJ, Samowitz W, Edwards CQ, West G, et al. Iron overload in Africa: interaction between a gene and dietary iron content. N Engl J Med 1992;326:95-100.
26. Bothwell TH, Seftel H, Jacobs P, Torrance JD. Iron overload in Bantu subjects: studies on the bioavailability of iron in Bantu beer. Am J Clin Nutr 1964;14:47-51.
27. Wapnick AA, Bothwell TH, Seftel H. The relationship between serum iron levels and ascorbic acid stores in siderotic Bantu. Br J Haematol 1970;19:271-6.
28. Roeser HP, Halliday JW, Sizemore DJ, Nikles A, Willgoss D. Serum ferritin in ascorbic acid deficiency. Br J Haematol 1980; 45:457-66.
29. International Committee for Standardisation in Haematology (Iron Panel). Recommendations for the measurement of serum iron in human blood. Br J Haematol 1978;38:291-4.
30. International Committee for Standardisation in Haematology (Iron Panel). The measurement of total and unsaturated iron binding capacity in serum. Br J Haematol 1978;38:281-90.
31. International Committee for Standardization in Haematology. Recommendations for measurement of erythrocyte sedimentation rate of human blood. Am J Clin Pathol 1977;64:505-7.
32. Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute liver disease. Gastroenterology 1975; 68:525-33.
33. Ford C, Wells FE, Rodgers JN. Assessment of iron status in association with excess alcohol consumption. Ann Clin Biochem 1995;32:5227-31.
34. Siimes MA, Dallman PR. New kinetic role for serum ferritin in iron metabolism [Review]. Br J Haematol 1974;28:1-18.
35. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron metabolism in man. Oxford: Blackwell Scientific Publications, 1979:308.
36. Shih YJ, Baynes RD, Hudson BG, Flowers CCCH, Skikne BS, Cook JD. Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem 1990;265:19077-81.
37. Huebers HA, Finch CA. The physiology of transferrin and transferrin receptors [Review]. Physiol Rev 1987;67:520-87.
38. Beguin Y, Huebers HA, Josephson B, Finch CA. Transferrin receptors in rat plasma. Proc Natl Acad Sci U S A 1988;85:637-40.
39. Kohgo Y, Nishisato T, Kondo H, Tsushima N, Niitsu Y, Urushizaki I. Soluble transferrin receptor in human serum. Br J Haematol 1986;64:277-81.
40. Aungst CW. Ferritin in body fluids. J Lab Clin Med 1968;71: 517-22.
41. Reissmann KR, Diedrich MR. On the presence of ferritin in the peripheral blood of patients with hepatocellular disease. J Clin Invest 1956;35:588-95.