Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2

FEBS Letters

Volumn 581, Issue 28, 2007, Pages 5430-5434

  Kim, Hye Lim ^a   Choi, Yong Kee ^a   Kim, Do Hyung ^a   Park, Sun Ok ^a   Han, Jin ^b   Park, Young Shik ^a  

^a Inje University   (South Korea)

^b Bio Marker Research Center for Personalized Therapy   (South Korea)

Author keywords

Antioxidant; Mitochondria; Oxidative stress; Spore viability; Tetrahydrobiopterin; Tetrahydrodictyopterin

Indexed keywords

PTERIDINE DERIVATIVE; TETRAHYDROPTERIDINE; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL GROWTH; CELL PROTECTION; CELL VIABILITY; CHROMOSOME ANALYSIS; DICTYOSTELIUM DISCOIDEUM; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; DICTYOSTELIUM; MITOCHONDRIA; OXIDATIVE STRESS; PTERIDINES; SPORES, PROTOZOAN;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM;

EID: 36049020995     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.10.044     Document Type: Article

References (22)

1. Klein R., Thiery R., and Tatischeff I. Dictyopterin, 6-(d-threo-1,2-dihydroxypropyl)-pterin, a new natural isomer of l-biopterin. Eur. J. Biochem. 187 (1990) 665-669
2. Choi Y.K., Park J.S., Kong J.S., Morio T., and Park Y.S. d-threo-tetrahydrobiopterin is synthesized via 1′-oxo-2′-d-hydroxy-tetrahydropterin in Dictyostelium discoideum Ax2. FEBS Lett. 579 (2005) 3085-3089
3. Thöny B., Auerbach G., and Blau N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem. J. 347 (2000) 1-16
4. Channon K.M. Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease. Trends Cardiovasc. Med. 14 (2004) 323-327
5. Delgado-Esteban M., Almeida A., and Medina J.M. Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia. J. Neurochem. 82 (2002) 1148-1159
6. 2-induced endothelial cell injury. Pharmacol. Toxicol. 82 (1998) 280-286
7. Nakamura K., Bindokas V.P., Kowlessur D., Elas M., Milstien S., Marks J.D., Halpern H.J., and Kang U.J. Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. J. Biol. Chem. 276 (2001) 34402-34407
8. Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., et al. The genome of the social amoeba Dictyostelium discoideum. Nature 435 (2005) 43-57
9. Bonafe L., Thöny B., Penzien J.M., Czarnecki B., and Blau N. Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. Am. J. Hum. Genet. 69 (2001) 269-277
10. Yang S., Lee Y.J., Kim J.M., Park S., Peris J., Laipis P., Park Y.S., Chung J.H., and Oh S.P. A murine model for human sepiapterin-reductase deficiency. Am. J. Hum. Genet. 78 (2006) 575-587
11. Choi Y.K., Kong J.S., and Park Y.S. Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2. Biochim. Biophys. Acta 1760 (2006) 877-882
12. Watts D.J., and Ashworth J.M. Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture. Biochem. J. 119 (1970) 171-174
13. Morrissey J.H., Farnsworth P.A., and Loomis W.F. Pattern formation in Dictyostelium discoideum: an analysis of mutants altered in cell proportioning. Dev. Biol. 15 (1981) 1-8
14. Cotter D.A., and George R.P. Germination and mitochondrial damage in spores of Dictyostelium discoideum following supraoptimal heating. Arch. Microbiol. 103 (1975) 163-168
15. Klein R., Tatischeff I., and Cotter D. Dictyopterin appears at amoebae emergence during spore germination in Dictyostelium. C.R. Acad. Sci. III 319 (1996) 289-294
16. Kono Y., and Fridovich I. Inhibition and reactivation of Mn-catalase. J. Biol. Chem. 258 (1984) 13646-13648
17. Katoch B., and Begum R. Biochemical basis of the high resistance to oxidative stress in Dictyostelium discoideum. J. Biosci. 28 (2003) 581-588
18. Chida J., Yamaguchi H., Amagai A., and Maeda Y. The necessity of mitochondrial genome DNA for normal development of Dictyostelium cells. J. Cell Sci. 117 (2004) 3141-3152
19. Maeda Y. Regulation of growth and differentiation in Dictyostelium. Int. Rev. Cytol. 244 (2005) 287-332
20. Tao Y.P., Misko T.P., Howlett A.C., and Klein C. Nitric oxide, an endogenous regulator of Dictyostelium discoideum differentiation. Development 124 (1997) 3587-3595
21. Welker D.L., and Deering R.A. Genetics of radiation sensitivity in the slime mold Dictyostelium discoideum. J. Gen. Microbiol. 109 (1978) 11-23
22. Wallace S.S. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat. Res. 150 (1998) S60-S79