Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2

Biochimica et Biophysica Acta - General Subjects

Volumn 1760, Issue 6, 2006, Pages 877-882

  Choi, Yong Kee ^a   Kong, Jin Sun ^a   Park, Young Shik ^a  

^a Inje University   (South Korea)

Author keywords

Catalytic function; Developmental expression; Dictyopterin; Dictyostelium; Sepiapterin reductase; Tetrahydrobiopterin

Indexed keywords

1' OXO 2' DEXTRO HYDROXYPROPYLTETRAHYDROPTERIN; 6 PYRUVOYLTETRAHYDROPTERIN SYNTHASE; ALDEHYDE REDUCTASE; DEXTRO THREO TETRAHYDROPTERIDINE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; LEVO ERYTHRO TETRAHYDROPTERIDINE; PTERIDINE DERIVATIVE; SEPIAPTERIN REDUCTASE; TETRAHYDROPTERIDINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CONTROLLED STUDY; DICTYOSTELIUM DISCOIDEUM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME MECHANISM; ENZYME SUBSTRATE; GENETIC TRANSCRIPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SPACE; MUTANT; NONHUMAN; NORTHERN BLOTTING; PARASITE DEVELOPMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; STEREOISOMERISM;

ALCOHOL OXIDOREDUCTASES; ANIMALS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICTYOSTELIUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; PTERIDINES; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TIME FACTORS;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM;

EID: 33744508567     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2005.11.017     Document Type: Article

References (16)

1. Thöny B., Auerbach G., and Blau N. Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem. J. 347 (2000) 1-16
2. Werner-Felmayer G., Golderer G., and Werner E.R. Tetrahydrobiopterin biosynthesis, utilization and pharmacological effects. Curr. Drug Metab. 3 (2002) 159-173
3. Klein R., Thiery R., and Tatischeff I. Dictyopterin, 6-(d-threo-1,2-dihydroxypropyl)-pterin, a new natural isomer of l-biopterin. Isolation from vegetative cells of Dictyostelium discoideum and identification. Eur. J. Biochem. 187 (1990) 665-669
4. Gütlich M., Witter K., Bourdais J., Veron M., Rödl W., and Ziegler I. Control of 6-(d-threo-1′,2′-dihydroxypropyl) pterin (dictyopterin) synthesis during aggregation of Dictyostelium discoideum. Involvement of the G-protein-linked signalling pathway in the regulation of GTP cyclohydrolase I activity. Biochem. J. 314 (1996) 95-101
5. Choi Y.K., Park J.S., Kong J.S., Morio T., and Park Y.S. d-threo-tetrahydrobiopterin is synthesized via 1′-oxo-2′-d-hydroxy-tetrahydropterin in Dictyostelium discoideum Ax2. FEBS Lett. 579 (2005) 3085-3089
6. Katoh S., and Sueoka T. Coenzyme stimulation of isomerase activity of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin. J. Biochem. 103 (1988) 286-289
7. Auerbach G., Herrmann A., Gütlich M., Fisher M., Jacob U., Bacher A., and Huber R. The 1.25 Å crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. EMBO J. 16 (1997) 7219-7230
8. Milstien S., and Kaufman S. Immunological studies on the participation of 6-pyruvoyl tetrahydropterin (2′-oxo) reductase, an aldose reductase, in tetrahydrobiopterin biosynthesis. Biochem. Biophys. Res. Commun. 165 (1989) 845-850
9. Park Y.S., Heizmann C.W., Wermuth B., Levine R.A., Steinerstauch P., Guzman J., and Blau N. Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis. Biochem. Biophys. Res. Commun. 175 (1991) 738-744
10. Ziegler I., and Gütlich M. Tetrahydropterins interfere with the G protein pathway in Dictyostelium discoideum. Biochem. Biophys. Res. Commun. 221 (1996) 368-373
11. Watts D.J., and Ashworth J.M. Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture. Biochem. J. 119 (1970) 171-174
12. Martens H., Novotny J., Oberstrass J., Steck T.L., Postlethwait P., and Nellen W. RNAi in Dictyostelium: the role of RNA-directed RNA polymerases and double-stranded Rnase. Mol. Biol. Cell 13 (2002) 445-453
13. Kim Y.A., Chung H.J., Kim Y.J., Choi Y.K., Hwang Y.K., Lee S.W., and Park Y.S. Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli. Mol. Cells 10 (2000) 405-410
14. Lee S.W., Lee H.W., Chung H.J., Kim Y.-A., Kim Y.J., Chung J.H., and Park Y.S. Identification of the genes encoding enzymes involved in the early biosynthetic pathway of pteridines in Synechocystis sp. PCC 6803. FEMS Microbiol. Lett. 176 (1999) 169-176
15. Woo H.J., Kang J.Y., Choi Y.K., and Park Y.S. Production of sepiapterin in Escherichia coli by coexpression of cyanobacterial GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase. Appl. Environ. Microbiol. 68 (2002) 3138-3140
16. Bonafe L., Thony B., Penzien J.M., Czarnecki B., and Blau N. Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. Am. J. Hum. Genet. 69 (2001) 269-277