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The Cardiovascular Health Study Collaborative Research Group: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults
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Common carotid intima-media thickness and risk of stroke and myocardial infarction: The Rotterdam Study
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Incidence of stroke is related to carotid IMT even in the absence of plaque
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Lorenz MW, von Kegler S, Steinmetz H, et al. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke 2006; 37:87-92. Epidemiological study showing that carotid IMT independently predicts future vascular events and that its predictive value is at least as high in younger subjects as in older subjects.
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14
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Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysis
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A meta-analysis of data from eight epidemiological studies showing that carotid IMT is a strong predictor of future vascular events
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Lorenz, M.W.1
Markus, H.S.2
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15
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Differences in intima-media thickness in the carotid and femoral arteries in familial hypercholesterolemic heterozygotes with and without clinical manifestations of cardiovascular disease
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Wittekoek ME, de Groot E, Prins MH, et al. Differences in intima-media thickness in the carotid and femoral arteries in familial hypercholesterolemic heterozygotes with and without clinical manifestations of cardiovascular disease. Atherosclerosis 1999; 146:271-279.
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Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia
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19
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34548186503
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Statin treatment in children with familial hypercholesterolemia: The younger, the better
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A study that shows that early initiation of statin therapy in children with familial hypercholesterolemia might be beneficial in the prevention of atherosclerosis in adolescence
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Rodenburg J, Vissers MN, Wiegman A, et al. Statin treatment in children with familial hypercholesterolemia: the younger, the better. Circulation 2007; 116:664-668. A study that shows that early initiation of statin therapy in children with familial hypercholesterolemia might be beneficial in the prevention of atherosclerosis in adolescence.
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Rodenburg, J.1
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A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease
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Hovingh GK, Brownlie A, Bisoendial RJ, et al. A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J Am Coll Cardiol 2004; 44:1429-1435.
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Wang JG, Staessen JA, Li Y, et al. Carotid intima-media thickness and antihypertensive treatment. A meta-analysis of randomized controlled trials. Stroke 2006; 37:1933-1940. A meta-analysis showing that antihypertensive treatment reduces carotid intima-media thickening.
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Wang JG, Staessen JA, Li Y, et al. Carotid intima-media thickness and antihypertensive treatment. A meta-analysis of randomized controlled trials. Stroke 2006; 37:1933-1940. A meta-analysis showing that antihypertensive treatment reduces carotid intima-media thickening.
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23
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Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus
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A study showing that the antiatherogenic effect of antihypertensive agents can be detected by B-mode ultrasound in patients with diabetes mellitus
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Zheng L, Hodis HN, Buchanan TA, et al. Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus. Am J Cardiol 2007; 99:956-960. A study showing that the antiatherogenic effect of antihypertensive agents can be detected by B-mode ultrasound in patients with diabetes mellitus.
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Buchanan, T.A.3
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24
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33845491101
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Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events
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An interesting study, showing that there is no association between carotid intima-media thickness and C-reactive protein gene polymorphisms
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Lange LA, Carlson CS, Hindorff LA, et al. Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. J Am Med Assoc 2006; 296:2703-2711. An interesting study, showing that there is no association between carotid intima-media thickness and C-reactive protein gene polymorphisms.
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Lange, L.A.1
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Lee WY, Allison MA, Kim DJ, et al. Association of interleukin-6 and C-reactive protein with subclinical carotid atherosclerosis (the Rancho Bernardo Study). Am J Cardiol 2007; 99:99-102. A study showing that interleukin-6 and C-reactive protein are associated with carotid intima-media thickness, but the association of C-reactive protein was independent of interleukin-6.
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Lee WY, Allison MA, Kim DJ, et al. Association of interleukin-6 and C-reactive protein with subclinical carotid atherosclerosis (the Rancho Bernardo Study). Am J Cardiol 2007; 99:99-102. A study showing that interleukin-6 and C-reactive protein are associated with carotid intima-media thickness, but the association of C-reactive protein was independent of interleukin-6.
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26
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34248663781
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Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study)
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A large study showing a correlation between C-reactive protein and internal carotid intima-media thickness, but not with common carotid intima-media thickness or carotid stenosis
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Thakore AH, Guo CY, Larson MG, et al. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol 2007; 99:1598-1602. A large study showing a correlation between C-reactive protein and internal carotid intima-media thickness, but not with common carotid intima-media thickness or carotid stenosis.
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27
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Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: The Cardiovascular Health Study
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Cao JJ, Arnold AM, Manolio TA, et al. Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. Circulation 2007; 116:32-38. A study showing that, in older adults, elevated C-reactive protein was associated with increased risk for CVD and all-cause mortality only in those with detectable atherosclerosis based on carotid ultrasound.
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28
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34248343849
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Correlation between the Framingham risk score and intima media thickness: The Paroi Artérielle et Risque Cardiovasculaire (PARC) study
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A study showing that there is no clear correlation between CIMT and Framingham Risk Score
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Touboul, P.J.1
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31
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