Effects of aggressive versus conventional lipid-lowering therapy by simvastatin on human atherosclerotic lesions: A prospective, randomized, double-blind trial with high-resolution magnetic resonance imaging

Journal of the American College of Cardiology

Volumn 46, Issue 1, 2005, Pages 106-112

  Corti, Roberto ^a   Fuster, Valentin ^a   Fayad, Zahi A ^a   Worthley, Stephen G ^a   Helft, Gerard ^a   Chaplin, William F ^a   Muntwyler, Jörg ^b   Viles Gonzalez, Juan F ^a   Weinberger, Jesse ^a   Smith, Donald A ^a   Mizsei, Gabor ^a   Badimon, Juan J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN;

ADULT; AGED; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL WALL; BRAIN ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; FEMALE; FOLLOW UP; HUMAN; HYPERCHOLESTEROLEMIA; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; NON INVASIVE MEASUREMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTILIPEMIC AGENTS; AORTA, THORACIC; ARTERIOSCLEROSIS; CAROTID ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERCHOLESTEROLEMIA; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SIMVASTATIN; TIME FACTORS;

EID: 21344434595     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2005.03.054     Document Type: Article

References (25)

1. M. Aikawa, E. Rabkin, S. Sugiyama An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro Circulation 103 2001 276 283
2. M. Crisby, G. Nordin-Fredriksson, P.K. Shah, J. Yano, J. Zhu, J. Nilsson Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques implications for plaque stabilization Circulation 103 2001 926 933
3. X.Q. Zhao, C. Yuan, T.S. Hatsukami Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI a case-control study Arterioscler Thromb Vasc Biol 21 2001 1623 1629
4. P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
5. C.J. Vaughan, M.B. Murphy, B.M. Buckley Statins do more than just lower cholesterol Lancet 348 1996 1079 1082
6. A.M. Gottox Jr., J.A. Farmer Pleiotropic effects of statins do they matter? Curr Opin Lipidol 12 2001 391 394
7. M. Takemoto, J.K. Liao Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors Arterioscler Thromb Vasc Biol 21 2001 1712 1719
8. Z.A. Fayad, V. Fuster Clinical imaging of the high-risk or vulnerable atherosclerotic plaque Circ Res 89 2001 305 316
9. C. Yuan, K.W. Beach, L.H. Smith Jr., T.S. Hatsukami Measurement of atherosclerotic carotid plaque size in vivo using high resolution magnetic resonance imaging Circulation 98 1998 2666 2671
10. R. Corti, Z.A. Fayad, V. Fuster Effects of lipid-lowering by simvastatin on human atherosclerotic lesions a longitudinal study by high-resolution, noninvasive magnetic resonance imaging Circulation 104 2001 249 252
11. Effect of simvastatin on coronary atheroma the Multicentre Anti-Atheroma Study (MAAS) Lancet 344 1994 633 638
12. B.G. Brown, X.Q. Zhao, A. Chait Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease N Engl J Med 345 2001 1583 1592
13. R. Corti, V. Fuster, Z.A. Fayad Lipid lowering by simvastatin induces regression of human atherosclerotic lesions 2 years' follow-up by high-resolution noninvasive magnetic resonance imaging Circulation 106 2002 2884 2887
14. Z.A. Fayad, T. Nahar, J.T. Fallon In vivo magnetic resonance evaluation of atherosclerotic plaques in the human thoracic aorta a comparison with transesophageal echocardiography Circulation 101 2000 2503 2509
15. J.A. Lima, M.Y. Desai, H. Steen, W.P. Warren, S. Gautam, S. Lai Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitored therapy Circulation 110 2004 2336 2341
16. L.O. Jensen, P. Thayssen, K.E. Pedersen, S. Stender, T. Haghfelt Regression of coronary atherosclerosis by simvastatin a serial intravascular ultrasound study Circulation 110 2004 265 270
17. S.E. Nissen REVERSAL Investigators Comparison of intensive versus moderate lipid lowering on the progression of coronary atherosclerosis measured by intravascular ultrasound a randomized controlled trial Circulation 108 2003 2723
18. Heart Protection Study Collaborative Group MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals a randomised placebo-controlled trial Lancet 360 2002 7 22
19. M.V. McConnell, M. Aikawa, S.E. Maier, P. Ganz, P. Libby, R.T. Lee MRI of rabbit atherosclerosis in response to dietary cholesterol lowering Arterioscler Thromb Vasc Biol 19 1999 1956 1959
20. C.P. Cannon, E. Braunwald, C.H. McCabe Comparison of intensive and moderate lipid lowering with statins after acute coronary syndromes N Engl J Med 350 2004 1495 1504
21. J.A. de Lemos, M.A. Blazing, S.D. Wiviott Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes phase Z of the A to Z trial JAMA 292 2004 1307 1316
22. J.J. Badimon, L. Badimon, V. Fuster Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit J Clin Invest 85 1990 1234 1241
23. L.E. Spieker, I. Sudano, D. Hurlimann High-density lipoprotein restores endothelial function in hypercholesterolemic men Circulation 105 2002 1399 1402
24. S.E. Nissen, T. Tsunoda, E.M. Tuzcu Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes a randomized controlled trial JAMA 290 2003 2292 2300
25. R. Corti, J.I. Osende, J.T. Fallon The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis in vivo study by high-resolution magnetic resonance imaging J Am Coll Cardiol 43 2004 464 473