Clotrimazole, an antifungal drug possessing diverse actions, increases membrane permeation of cadmium in rat thymocytes

Toxicology in Vitro

Volumn 21, Issue 8, 2007, Pages 1505-1512

  Oyama, Tomohiro M ^a   Oyama, Toshihisa B ^a   Oyama, Keisuke ^a   Sakanashi, Yoko ^a   Morimoto, Midori ^a   Matsui, Hiroko ^a   Oyama, Yasuo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Clotrimazole; Cytotoxicity; Lymphocyte; Membrane; Metal cations

Indexed keywords

ANTIFUNGAL AGENT; CADMIUM; CADMIUM CHLORIDE; CALCIUM; CLOTRIMAZOLE; FLUO 3; LEAD; MANGANESE CHLORIDE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; FLUORESCENCE; MALE; MEMBRANE PERMEABILITY; NONHUMAN; RAT; THYMOCYTE; TOXICITY TESTING;

ANIMALS; ANTIFUNGAL AGENTS; CADMIUM; CALCIMYCIN; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CHLORIDES; CLOTRIMAZOLE; MALE; MANGANESE COMPOUNDS; RATS; RATS, WISTAR; THYMUS GLAND;

RATTUS;

EID: 36048957588     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.06.016     Document Type: Article

References (33)

1. + channels by cytochrome P-450 Inhibitors. J. Biol. Chem. 267 (1992) 11789-11793
2. 2+ binding and favoring the E2 conformation. J. Biol. Chem. 281 (2006) 9547-9551
3. + transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J. Clin. Invest. 92 (1993) 520-526
4. 2+. Pharmacol. Toxicol. 71 (1992) 190-195
5. 2-induced changes in cell viability and cellular nonprotein thiol level of dissociated rat thymocytes. Jpn. J. Pharmacol. 71 (1996) 299-305
6. 2 in rat lymphocytes. Toxicol. 225 (2006) 97-108
7. Isaev N.K., Stelmashook E.V., Dirnagl U., Anfreeva N.A., Manuhova L., Vorobjev V.S., Sharonava I.N., Skrebitsky V.G., Victorov I.V., Katchanov J., Weih M., and Zorov D.B. Neuroprotective effects of the antifungal drug clotrimazole. Neuroscience 113 (2002) 47-53
8. Ito C., Tecchio C., Coustan-Smith E., Suzuki T., Behm F.G., Raimondi S.C., Pui C.H., and Campana D. The antifungal antibiotic clotrimazole alters calcium homeostasis of leukemic lymphoblasts and induces apoptosis. Leukemia 16 (2002) 1344-1352
9. 2+ signaling in Madin Darby canine kidney cells. Life Sci. 66 (2000) 2289-2296
10. Kao J.P., Harootunian A.T., and Tsien R.Y. Photochemically generated cytosolic calcium pulse and their detection by fluo-3. J. Biol. Chem. 264 (1989) 8179-8184
11. 2-terminal kinase (JNK) and apoptosis in response to cadmium in murine macrophages. Toxicol. Sci. 81 (2004) 518-527
12. 2+-free condition. Toxicol. In Vitro 20 (2006) 211-216
13. 2+. Environ. Toxicol. Pharmacol. 45 (2003) 45-51
14. 2+ concentration of rat thymocytes. Jpn. J. Pharmacol. 71 (1996) 273-280
15. Oyama Y., Chikahisa L., Ueha T., Hatakeyama Y., and Kokubun T. Change in membrane permeability induced by amyloid-ß-protein fragment 25-35 in brain neurons dissociated from the rats. Jpn. J. Pharmacol. 68 (1995) 77-83
16. 2. Environ. Toxicol. Pharmacol. 11 (2002) 111-118
17. Oyama T.M., Oyama T.B., Oyama K., Matsui H., Horimoto K., Nishimura Y., and Oyama Y. Clotrimazole, an antifungal drug possessing diverse actions, increases the vulnerability to cadmium in lymphocytes dissociated from rat thymus. Toxicology 228 (2006) 269-279
18. Oyama, Y., Matsui, H., Morimoto, M., Sakanashi, Y., Nishimura, Y., Ishida, S., Okano, Y., 2007. Synergic cytotoxic action induced by simultaneous application of zinc and clotrimazole in rat thymocytes. Toxicol. Lett. doi:10.1016/j.toxlet.2007.05.003.
19. Penso J., and Beitner R. Clotrimazole decreases glycolysis and the viability of lung carcinoma and colon adenocarcinoma cells. Eur. J. Pharmacol. 451 (2002) 227-235
20. Rettenhouse A.R., Vandorpe D.H., Brugnara C., and Alper S.L. The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells. J. Membr. Biol. 157 (1997) 177-191
21. Rifai N., Sakamoto M., Law T., Platt O., Mikati M., Armsby C.C., and Brugnara C. HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin. Chem. 41 (1995) 387-391
22. Seo M., Iida H., and Miura Y. Basic experiments with clotrimazole administered orally. Curr. Med. Res. Opin. 5 (1977) 169-178
23. Shao J., Xi G., Hua Y., Schallert T., and Felt B. Intracerebral hemorrhage in the iron-deficient rat. Stroke 36 (2005) 660-664
24. Shen H.M., Dong S.Y., and Ong C.N. Critical role of calcium overloading in calcium-induced apoptosis in mouse thymocytes. Toxicol. Appl. Pharmacol. 171 (2001) 12-19
25. Smith M.A., Zhang W., Naziruddin B., Cooper J.D., Patterson G.A., and Mohanakumar T. Clotrimazole inhibits lung fibroblast proliferation in vitro: implications for use in the prevention and treatment of obliterative bronchiolitis after lung transplantation. Transplantation 70 (2000) 1263-1267
26. Snajdrova L., Xu A., and Narayanan N. Clotrimazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J. Biol. Chem. 273 (1998) 28032-28039
27. Usul H., Cakir E., Arslan E., Peksoylu B., Alver A., Sayin O.C., Topbas M., and Baykal S. Effects of clotrimazole on experimental spinal cord injury. Arch. Med. Res. 37 (2006) 571-575
28. Vanden Bossche H., Marichal P., Gorrens J., Coene M.C., Willemsens G., Bellens D., Roels I., and Janssen P.A. Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses 32 (1989) 35-52
29. Wan S., Hua Y., Keep R.F., Hoff J.T., and Xi G. Deferoxamine reduces CFS free iron levels following intracerebral hemorrhage. Acta Neurochir. Suppl. 96 (2006) 199-202
30. Welker S., and Drews G. Imidazole antimycotics affect the activity of various ion channels and insulin secretion in mouse pancreatic B-cells. Naunyn Schmiedebergs Arch. Pharmacol. 356 (1997) 543-550
31. + current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacol 38 (1999) 979-989
32. 2+ on mesencephalic trigeminal neurons of the adult rat. Brain Res. 892 (2001) 102-110
33. Yoshida Y., and Aoyama Y. Interaction of azole antifungal agents with cytochrome P-45014DM purified from Saccharomyces cerevisiae microsomes. Biochem. Pharmacol. 36 (1987) 229-235