Cell-specific epigenetic regulation of ChM-I gene expression: Crosstalk between DNA methylation and histone acetylation

Biochemical and Biophysical Research Communications

Volumn 365, Issue 1, 2008, Pages 124-130

  Aoyama, Tomoki ^a   Okamoto, Takeshi ^a,b   Kohno, Yoshiki ^a,b   Fukiage, Kenichi ^a   Otsuka, Seiji ^a,c   Furu, Moritoshi ^a   Ito, Kinya ^a,c   Jin, Yonghui ^a   Nagayama, Satoshi ^d   Nakayama, Tomitaka ^b   Nakamura, Takashi ^b   Toguchida, Junya ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Acetylation; Chondrogenic; Chondromodulin I; Differentiation; Epigenetic; H3 K9; HDAC2; Histone modification; Methylation

Indexed keywords

CHONDROMODULIN 1; GENE PRODUCT; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; LYSINE; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL SPECIFICITY; CHM I GENE; CONTROLLED STUDY; CPG ISLAND; DEACETYLATION; DNA METHYLATION; EPIGENETICS; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; METHYLATION; OSTEOSARCOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CROSS LINKING;

ACETYLATION; BINDING SITES; CELL LINE, TUMOR; DNA METHYLATION; DNA REPLICATION; EPIGENESIS, GENETIC; HISTONE DEACETYLASES; HISTONES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SP3 TRANSCRIPTION FACTOR;

EID: 36048956715     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.135     Document Type: Article

References (13)

1. Aoyama T., Okamoto T., Nagayama S., Nishijo K., Ishibe T., Yasura K., Nakayama T., Nakamura T., and Toguchida J. Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. J. Biol. Chem. 279 (2004) 28789-28797
2. Hiraki Y., Tanaka H., Inoue H., Kondo J., Kamizono A., and Suzuki F. Molecular cloning of a new class of cartilage-specific matrix, chondromodulin-I, which stimulates growth of cultured chondrocytes. Biochem. Biophys. Res. Commun. 175 (1991) 971-977
3. Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 8 (2007) 286-298
4. Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
5. Kondo Y., Shen L., and Issa J.P. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol. Cell. Biol. 23 (2003) 206-215
6. Zhao W., Soejima H., Higashimoto K., Nakagawachi T., Urano T., Kudo S., Matsukura S., Matsuo S., Joh K., and Mukai T. The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island. J. Biochem. (Tokyo) 137 (2005) 431-440
7. Gan Q., Yoshida T., McDonald O.G., and Owens G.K. Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells. Stem Cells 25 (2007) 2-9
8. Tamaru H., and Selker E.U. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414 (2001) 277-283
9. Cervoni N., and Szyf M. Demethylase activity is directed by histone acetylation. J. Biol. Chem. 276 (2001) 40778-40787
10. Ou J.N., Torrisani J., Unterberger A., Provencal N., Shikimi K., Karimi M., Ekstrom T.J., and Szyf M. Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines. Biochem. Pharmacol. 73 (2007) 1297-1307
11. Johnson L.M., Cao X., and Jacobsen S.E. Inteplay between two epigenetic marks: DNA methylation and histone H3 lysine 9 methlyation. Curr. Biol. 12 (2002) 1360-1372
12. Zhang Y., and Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Gene. Dev. 15 (2001) 2343-2360
13. Locklin R.M., Oreffo R.O., and Triffitt J.T. Modulation of osteogenic differentiation in human skeletal cells in Vitro by 5-azacytidine. Cell Biol. Int. 22 (1998) 207-215