The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-β tumor-suppressor gene in breast cancer cells

Differentiation

Volumn 75, Issue 9, 2007, Pages 883-890

  Grunt, Thomas W ^a   Tomek, Katharina ^a   Wagner, Renate ^a   Puckmair, Klaudia ^a   Zielinski, Christoph C ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cytotoxic anticancer drug; DNA intercalation; EGFR inhibitor; ErbB; PD153035; RAR expression

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; AMSACRINE; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; DNA; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; MESSENGER RNA; MITOXANTRONE; RECEPTOR SUBTYPE; RETINOIC ACID; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR BETA1; RETINOIC ACID RECEPTOR BETA4; UNCLASSIFIED DRUG; VINCRISTINE;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DRUG DNA BINDING; DRUG SPECIFICITY; DRUG TARGETING; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; MICROTUBULE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

EID: 36048948338     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1111/j.1432-0436.2007.00199.x     Document Type: Article

References (31)

1. Altucci, L. Gronemeyer, H. (2001) The promise of retinoids to fight against cancer. Nat Rev Cancer 1 : 181 193.
2. Chambon, P. (1996) A decade of molecular biology of retinoic acid receptors. FASEB J 10 : 940 954.
3. Fry, D.W., Kraker, A.J., McMichael, A., Ambroso, L.A., Nelson, J.M., Leopold, W.R., Connors, R.W. Bridges, A.J. (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 : 1093 1095.
4. Goossens, J.-F., Bouey-Bencteux, E., Houssin, R., Henichart, J.P., Colson, P., Houssier, C., Laine, W., Baldeyrou, B. Bailly, C. (2001) DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue. Biochemistry 40 : 4663 4671.
5. Grunt, T.W. (2003) Tyrphostins and retinoids cooperate during inhibition of in vitro growth of ovarian cancer cells. Cancer Lett 189 : 147 156.
6. Grunt, T.W., Dittrich, E., Offterdinger, M., Schneider, S.M., Dittrich, C. Huber, H. (1998) Effects of retinoic acid and fenretinide on the c-erbB-2 expression, growth and cisplatin sensitivity of breast cancer cells. Brit J Cancer 78 : 79 87.
7. Grunt, T.W., Puckmair, K., Tomek, K., Kainz, B. Gaiger, A. (2005) An EGF receptor inhibitor induces RAR-β expression in breast and ovarian cancer cells. Biochem Biophys Res Commun 329 : 1253 1259.
8. Grunt, T.W., Tomek, K., Wagner, R., Puckmair, K., Kainz, B., Rünzler, D., Gaiger, A., Köhler, G. Zielinski, C.C. (2007) Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of erbB pathways. J Cell Physiol 211 : 803 815.
9. Hynes, N. (2000) Tyrosine kinase signalling in breast cancer. Breast Cancer Res 2 : 154 157.
10. Lee, X., Si, S.P., Tsou, H.C. Peacocke, M. (1995) Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2. Exp Cell Res 218 : 296 304.
11. Lichtner, R.B., Menrad, A., Sommer, A., Klar, U. Schneider, M.R. (2001) Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors. Cancer Res 61 : 5790 5795.
12. Lin, F., Xiao, D., Kolluri, S.K. Zhang, X. (2000) Unique anti-activator protein-1 activity of retinoic acid receptor beta. Cancer Res 60 : 3271 3280.
13. Lin, S.-Y., Makino, K., Xia, W., Matin, A., Wen, Y., Kwong, K.Y., Bourguignon, L. Hung, M.-C. (2001) Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3 : 802 808.
14. Liu, Y., Lee, M., Wang, H.-G., Li, Y., Hashimoto, Y., Klaus, M., Reed, J.C. Zhang, X.-K. (1996) Retinoic acid receptor β mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol Cell Biol 16 : 1138 1149.
15. Mendelsohn, J. Baselga, J. (2000) The EGF receptor family as targets for cancer therapy. Oncogene 19 : 6550 6565.
16. Ni, C.-Y., Murphy, M.P., Golde, T.E. Carpenter, G. (2001) Gamma-secretase cleavage and nuclear localization of erbB-4 receptor tyrosine kinase. Science 294 : 2179 2181.
17. Offterdinger, M., Schneider, S.M. Grunt, T.W. (2003) Heregulin and retinoids synergistically induce branching morphogenesis of breast cancer cells cultivated in 3D collagen gels. J Cell Physiol 195 : 260 275.
18. Offterdinger, M., Schneider, S.M., Huber, H. Grunt, T.W. (1998) Retinoids control the expression of c-erbB receptors in breast cancer cells. Biochem Biophys Res Commun 251 : 907 913.
19. Offterdinger, M., Schneider, S.M., Huber, H. Grunt, T.W. (1999) Expression of c-erbB-4/HER4 is regulated in T47D breast carcinoma cells by retinoids and vitamin D3. Biochem Biophys Res Commun 258 : 559 564.
20. Offterdinger, M., Schöfer, C., Weipoltshammer, K. Grunt, T.W. (2002) C-erbB-3: a nuclear protein in mammary epithelial cells. J Cell Biol 157 : 929 939.
21. Reich, Z., Ghirlando, R., Arad, T., Weinberger, S. Minsky, A. (1990) Extensive interference of DNA packaging processes affected by chemotherapeutic drugs. J Biol Chem 265 : 16004 16006.
22. Schneider, S.M., Offterdinger, M., Huber, H. Grunt, T.W. (1999) Involvement of nuclear steroid/retinoid/thyroid receptors and of protein kinases in the regulation of growth and of c-erbB and retinoic acid receptor expression in MCF-7 breast cancer cells. Breast Cancer Res Treatm 58 : 171 181.
23. Sirchia, S.M., Ferguson, A.T., Sironi, E., Subramanyan, S., Orlandi, R., Sukumar, S. Sacchi, N. (2000) Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor β2 promoter in breast cancer cells. Oncogene 19 : 1556 1563.
24. Sirchia, S.M., Ren, M., Pili, R., Sironi, E., Somenzi, G., Ghidoni, R., Toma, S., Nicolo, G. Sacchi, N. (2002) Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. Cancer Res 62 : 2455 2461.
25. Swisshelm, K., Ryan, K., Lee, X., Tsou, H.C., Peacocke, M. Sager, R. (1994) Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ 5 : 133 141.
26. Tighe, A.P. Talmage, D.A. (2004) Retinoids arrest breast cancer cell proliferation: retinoic acid selectively reduces the duration of receptor tyrosine kinase signaling. Exp Cell Res 301 : 147 157.
27. Tu, Y., Xu, F.H., Liu, J., Vescio, R., Berenson, J., Fady, C. Lichtenstein, A. (1996) Upregulated expression of BCL-2 in multiple myeloma cells induced by exposure to doxorubicin, etoposide, and hydrogen peroxide. Blood 88 : 1805 1812.
28. Widschwendter, M., Berger, J., Daxenbichler, G., Muller-Holzner, E., Widschwendter, A., Mayr, A., Marth, C. Zeimet, A.G. (1997) Loss of retinoic acid receptor beta expression in breast cancer and morphologically normal adjacent tissue but not in the normal breast tissue distant from the cancer. Cancer Res 57 : 4158 4161.
29. Widschwendter, M., Berger, J., Hermann, M., Muller, H.M., Amberger, A., Zeschnigk, M., Widschwendter, A., Abendstein, B., Zeimet, A.G., Daxenbichler, G. Marth, C. (2000) Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer. J Natl Cancer Inst 92 : 826 832.
30. Xie, Y. Hung, M.-C. (1994) Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation. Biochem Biophys Res Commun 203 : 1589 1598.
31. Yang-Yen, H.F., Zhang, X.-K., Graupner, G., Tzukerman, M., Sakamoto, B., Karin, M. Pfahl, M. (1991) Antagonism between retinoic acid receptors and AP-1: implications for tumor promotions and inflammation. New Biol 3 : 1206 1219.