Molecular cloning and biochemical characterization of VIM-12, a novel hybrid VIM-1/VIM-2 metallo-β-lactamase from a Klebsiella pneumoniae clinical isolate, reveal atypical substrate specificity

Biochemistry

Volumn 46, Issue 45, 2007, Pages 13170-13178

  Kontou, Maria ^a   Pournaras, Spyros ^a   Kristo, Ioulia ^a   Ikonomidis, Alexandras ^a   Maniatis, Antonios N ^a   Stathopoulos, Constantinos ^a,b  

^a UNIVERSITY OF THESSALY   (Greece)

^b INSTITUTE OF HUMAN PERFORMANCE AND REHABILITATION   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL CHARACTERIZATION; KLEBSIELLA PNEUMONIAE CLINICAL ISOLATE; MOLECULAR CLONING; SUBSTRATE SPECIFICITY;

ANTIBIOTICS; CLONING; GENE ENCODING; MOLECULAR STRUCTURE; PATHOGENS; SUBSTRATES;

ENZYME INHIBITION;

AZTREONAM; BETA LACTAM ANTIBIOTIC; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; IMIPENEM; MEROPENEM; METALLO BETA LACTAMASE; PENICILLIN G; PROTEIN VIM 1; PROTEIN VIM 12; PROTEIN VIM 2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE EXPRESSION; GENE FUNCTION; GREECE; KINETICS; KLEBSIELLA PNEUMONIAE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

AGED; AMINO ACID SEQUENCE; BETA-LACTAMASES; CLONING, MOLECULAR; ESCHERICHIA COLI; HUMANS; KINETICS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

KLEBSIELLA PNEUMONIAE;

EID: 36048929194     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701258w     Document Type: Article

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