Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38αMAPK inhibitors in Werner syndrome cells

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 24, 2007, Pages 6832-6835

  Davis, Terence ^a   Bagley, Mark C ^a   Dix, Matthew C ^a   Murziani, Paola G S ^a   Rokicki, Michal J ^a   Widdowson, Caroline S ^a   Zayed, Jameel M ^a   Bachler, Marcus A ^a   Kipling, David ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Heterocycles; Inflammation; Inhibitors; Microwaves; p38 MAP kinases; Senescence; Werner syndrome

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZOPYRANOPYRIDINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL IMMORTALIZATION; CONCENTRATION RESPONSE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; GROWTH RATE; HEATING; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VIVO STUDY; INHIBITION KINETICS; MICROWAVE RADIATION; SENESCENCE; SKIN FIBROBLAST; WERNER SYNDROME;

CELL LINE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 14; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; SUBSTRATE SPECIFICITY; WERNER SYNDROME;

EID: 35848965688     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.036     Document Type: Article

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