Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension

Journal of Hypertension

Volumn 25, Issue 12, 2007, Pages 2471-2478

  Tümer, Nihal ^a,b,c   Erdös, Benedek ^a,b   Matheny, Michael ^b   Cudykier, Idan ^a,b   Scarpace, Philip J ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

Author keywords

Blood pressure; Leptin antagonist; Leptin signaling; STAT3 phosphorylation; Sympathetic nervous system; Tyrosine hydroxylase

Indexed keywords

ANTIHYPERTENSIVE AGENT; LEPTIN; LEPTIN ANTAGONIST; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC DIET; BLOOD PRESSURE REGULATION; CERVICAL GANGLION; CONTROLLED STUDY; DRUG INFUSION; ENZYME ACTIVITY; FOOD INTAKE; HEART RATE; HYPERTENSION; HYPOTHALAMUS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WEIGHT GAIN;

ANIMALS; DEPENDOVIRUS; DIETARY FATS; GENE EXPRESSION; GENETIC VECTORS; HYPERTENSION; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MUTAGENESIS, SITE-DIRECTED; OBESITY; PHOSPHORYLATION; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 35848935007     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e3282e9a9fd     Document Type: Article

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