Enhanced oromucosal delivery of progesterone via hexosomes

Pharmaceutical Research

Volumn 24, Issue 12, 2007, Pages 2223-2230

  Swarnakar, Nitin K ^a   Jain, Vikas ^a   Dubey, Vaibhav ^a   Mishra, Dinesh ^a   Jain, N K ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Hexosomes; Oromucosal delivery; Permeation enhancement; Progesterone

Indexed keywords

HEXOSOME; LIPID; OLEIC ACID; PROGESTERONE; SURFACTANT; UNCLASSIFIED DRUG;

ALBINISM; ANIMAL TISSUE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; IN VITRO STUDY; INFRARED SPECTROSCOPY; MUCOSA; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DIFFUSION CHAMBERS, CULTURE; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; ETHANOL; GLYCERIDES; KINETICS; LIPOSOMES; MICROSCOPY, CONFOCAL; MOUTH MUCOSA; OLEIC ACID; PARTICLE SIZE; PERMEABILITY; PROGESTERONE; PROGESTINS; RABBITS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS;

EID: 35848932289     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9409-y     Document Type: Article

References (47)

1. M. J. Rathbone, and J. Hadgraft. Absorption of drugs from the human oral cavity. Int. J. Pharm. 74:9-24 (1991).
2. N. Salamat-Miller, M. C. Thomas, and P. Johnston. The use of mucoadhesive polymers in buccal drug delivery. Adv. Drug Deliv. Rev. 57:1666-1691 (2005).
3. L. M. C. Collins, and C. Dawes. The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa. J. Dent. Res. 66:1300-1302 (1987).
4. J. W. Lee, J. H. Park, and J. R. Robinson. Bioadhesive-based dosage forms: The next generation. J. Pharm. Sci. 89:850-866 (2000).
5. M. E. de Vries, H. E. Bodde, J. C. Verhoef, and H. E. Junginger. Developments in buccal drug delivery. Crit. Rev. Ther. Drug Carr. Syst. 8:271-303 (1991).
6. J. E. Levine, P. E. Chappell, J. S. Schneider, N. C. Sleiter, and M. Szabo. Progesterone receptors as neuroendocrine regulators. Front. Neuroendocrinol. 22:69-106 (2001).
7. P. E. Mann, and R. S. Bridges. Lactogenic hormone regulation of maternal behavior. Prog. Brain Res. 133:251-262 (2001).
8. C. K. Wagner. The many faces of progesterone: A role in adult and developing male brain. Front. Neuroendocrinol. 27:340-359 (2006).
9. M. I. Whitehead, P. T. Townsend, D. K. Gill, W. P. Collins, and S. Campbell. Absorption and metabolism of oral progesterone. Br. Med. J. 280:825-929 (1980).
10. T. R. Norman, C. Morse, and L. Dennerstein. Comparative bioavailability of orally and vaginally administered progesterone. Fertil. Steril. 56:1034-1039 (1991).
11. H. Adlercreutz, and F. Martin. Biliary excretion and intestinal metabolism of progesterone and estrogens in man. J. Steroid Biochem. 13:231-244 (1989).
12. M. E. Johnson, D. Blankschtein, and R. Langer. Permeation of steroids through human skin. J. Pharm. Sci. 84:1144-1146 (1995).
13. K. J. Chang, T. T. Y. Lee, G. Linares-Cruz, S. Fournier, and B. de Lignieres. Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo. Fertil. Steril. 63:785-791 (1995).
14. Cooper, C. Spencer, M. I. Whitehead, D. Ross, G. J. Barnard, and W. P. Collins. Systemic absorption of progesterone from Progest cream in post-menopausal women. Lancet 351:1255-1256 (1998).
15. B. G. Wren, K. McFarland, and L. Edwards. Micronized transdermal progesterone and endometrial response. Lancet 354:1447-1448 (1999).
16. P. O'Leary, P. Feddema, K. Chan, M. Taranto, M. Smith, and S. Evans. Salivary, but not serum or urinary levels of progesterone are elevated after topical application of progesterone cream to pre- and post-menopausal women. Clin. Endocrinol. 53:615-620 (2000).
17. C. Valenta, C. E. Kast, I. Harich, and A. Bernkop-Schnurch. Development and in vitro evaluation of a mucoadhesive vaginal delivery system for progesterone. J. Control. Release 77:323-332 (2001).
18. M. Furuhjelm, C. Karlgren, and K. Carlstrom. Intravaginal administration of conjugated estrogens in postmenopausal women. Int. J. Gynecol. Obstet. 17:335-339 (1980).
19. S. Hyde, S. Andersson, K. Larsson, Z. Blum, T. Landh, S. Lidin, and B. W. Ninham. The Language of Shape. The Role of Curvature in Condensed Matter: Physics, Chemistry and Biology. Elsevier, Amsterdam, 1997.
20. II) phase and non-lamellar phase transitions of lipids. Biochim. Bipohys. Acta 1031:1-69 (1990).
21. S. Engstrom, B. Lindman, and K. Larsson. Method of preparing controlled release preparations for biologically active materials and resulting compositions. US Patent no. 5,151,272 (1992).
22. T. Norling, P. Lading, S. Engstrom, K. Larsson, N. Krog, and S. S. Nissen. Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of periodontol disease. J. Clin. Periodontol. 19:687-692 (1992).
23. C. J. Drummond, and C. Fong. Surfactant self-assembly objects as novel drug delivery vehicles. Curr. Opin. Colloid Interface Sci. 4:449-456 (2000).
24. P. T. Spicer, K. L. Hayden, M. L. Lynch, A. Ofori-Boateng, and J.L. Burns. Novel process for producing cubic liquid crystalline nanoparticles (Cubosomes). Langmuir 17:5748-5756 (2001).
25. H. C. Chung, J. Kim, J. Y. Um, I.C. Kwon, and S. Y. Jeong. Self-assembled "nanocubicle" as a carrier for peroral insulin delivery. Diabetologia 45:448-451 (2002).
26. V. Pucci, F. Bugamelli, M. Roberto, B. Luppi, and M. A. Raggi. Determination of progesterone in commercial formulations and in non conventional micellar systems. J. Pharm. Biomed. Anal. 30:1549-1559 (2003).
27. E. Esposito, R. Cortesi, M. Drechsler, L. Paccamiccio, P. Mariani, C. Contado, E. Stellin, E. Menegatti, F. Bonina, and C. Puglia. Cubosome dispersions as delivery systems for percutaneous administration of indomethacin. Pharma Res. 22:2163-2173 (2005).
28. C. A. Squier, P. S. Cox, P. W. Wertz, D. T. Downing. The lipid composition of porcine epidermis and oral epithelium. Arch. Oral Biol. 31:741-747 (1986).
29. M. Bouclier, A. Chatelus, and C. N. Hensby. In vivo animal models for the evaluation of anti-inflammatory drug action in the skin. In N. J. Lowe and C.N. Hensby (eds.), Nonsteroidal Anti-inflammatory Drugs, Karger, Basel, 1989, pp. 118-132.
30. E. Touitou, and B. Fabin. Altered skin permeation of a highly lipophilic molecule: Tetrahydrocannabinol. Int. J. Pharm. 43:17-22 (1988).
31. F. B. Rosevear. The microscopy of the liquid crystalline neat and middle phases of soaps and detergents. J. Am. Oil Chem. Soc. 31:628-639 (1954).
32. M. Nakano, T. Teshigawara, A. Sugita, W. Leesajakul, A. Taniguchi, T. Kamo, H. Matsuoka, and T. Handa. Dispersion of liquid crystalline phases of the monoolein/oleic acid/pluronic F127 system. Lagmuir 18:9283-9288 (2002).
33. G. M. Golden, D. B. Guzek, R. R. Harris, J. E. McKie, and R. O. Potts. Lipid thermotropic transitions in human stratum corneum. J. Invest. Derrnatol. 86:255-259 (1986).
34. Schatzlein, and G. Cevc. Non uniform cellular packing of the stratum corneum and permeability barrier function of the intact skin: A high resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes). Br. J. Dermatol. 138:583-592 (1998).
35. B. A. I. Van den berg, J. Vroom, H. Gerritsen, H. E. Junginger, and J. A. Bowstra. Interactions of elastic and rigid vesicles with human skin in vitro: Electron microscopy and two photon excitation microscopy. Biochim. Biophys. Acta 146:155-173 (1999).
36. V. Dubey, D. Mishra, A. Asthana, and N. K. Jain. Transdermal delivery of a pineal hormone: Melatonin via elastic liposomes. Biomaterials 27:3491-3496 (2006).
37. L. Wang, Y. Q. Cai, B. He, C. G. Yuan, D. Z. Shen, J. Shao, and G. B. Jiang. Determination of estrogens in water by HPLC-UV using cloud point extraction. Talanta 70:47-51 (2006).
38. J. Israelchvili. Intermolecular and Surface Forces. Academic, San Diego, CA, 1992.
39. J. Borne, T. Nylander, and A. Khan. Phase behaviour and aggregate formation for the aqueous monoolein system mixed with sodium oleate and oleic acid. Langmuir 17:7742-7751 (2001).
40. C. M. Chang, and R. Bodmeier. Effect of dissolution media and additives on the drug release from cubic phase delivery systems. J. Control. Release 46:215-222 (1997).
41. T. M. Turunen, A. Urtti, P. Paronen, K. L. Audus, and J. H. Rytting. Effect of some penetration enhancers of epithelial membrane lipid domains: Evidence from fluorescence spectroscopy studies. Pharma Res. 11:288-294 (1994).
42. 5] enkephalin from a cubic phase of glyceryl monooleate. Int. J. Pharm. 204:137-144 (2000).
43. J. Gustafsson, H. Ljusberg-Wahren, M. Almgren, and K. Larsson. Cubic lipid-water phase dispersed into submicron particles. Langmuir 12:4611-4613 (1996).
44. J. Gustafsson, H. Ljusberg-Wahren, M. Almgren, and K. Larsson. Submicron particles of reversed lipid phases in water stabilized by a nonionic amphiphilic polymer. Langmuir 13:6964-6971 (1997).
45. J. Barauskas, M. Johnsson, and F. Tiberg. Self-assembled lipid superstructures: beyond vesicles and liposomes. Nano Lett. 5:1615-1619 (2005).
46. D. Bommannan, R. O. Potts, and R. H. Guy. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J. Invest. Dermatol. 95:403-408 (1990).
47. G. M. Golden, J. E. McKie, and R. O. Potts. Role of stratum corneum lipid fluidity in transdermal drug flux. J. Pharm. Sci. 76:25-28 (1987).