Trypanosoma cruzi: Attenuation of virulence and protective immunogenicity after monoallelic disruption of the cub gene

Experimental Parasitology

Volumn 117, Issue 4, 2007, Pages 382-389

  Barrio, Alejandra B ^a   Van Voorhis, Wesley C ^b   Basombrío, Miguel A ^a  

^a UNIVERSIDAD NACIONAL DE SALTA   (Argentina)

^b UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Attenuation; Calmodulin ubiquitin; calmodulin ubiquitin associated gene; Cub; deoxyribonucleic acid; DNA; FBM; fresh blood mount; LIT; liver infusion tryptose medium; PCR; polymerase chain reaction; retransfected line; RL; T. cruzi clone with monoallelic deletion of cub gene; Targeted deletion; Trypanosoma cruzi; TulCub8; Virulence; wild type; WT

Indexed keywords

CALCIUM BINDING PROTEIN; CALMODULIN; GENE PRODUCT; PROTEIN TULCUB8; UBIQUITIN; UNCLASSIFIED DRUG;

ALLELIC IMBALANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CUB GENE; EPIMASTIGOTE; GENE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENETIC STABILITY; IMMUNOGENICITY; MOUSE; NEWBORN; NONHUMAN; PARASITE VIRULENCE; PARASITEMIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STABILITY; TRYPANOSOMA CRUZI; WILD TYPE;

ALLELES; ANIMALS; ANIMALS, NEWBORN; BLOTTING, SOUTHERN; CALMODULIN; ELECTROPORATION; FEMALE; GENE DELETION; GENETIC COMPLEMENTATION TEST; MICE; MICE, INBRED BALB C; MULTIGENE FAMILY; TRANSFECTION; TRYPANOSOMA CRUZI; UBIQUITIN; VIRULENCE;

MUS; TRYPANOSOMA CRUZI;

EID: 35748986160     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2007.05.005     Document Type: Article

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