Regulation of allergen-induced bone marrow eosinophilopoiesis: Role of CD4+ and CD8+ T cells

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 62, Issue 12, 2007, Pages 1410-1418

  Radinger M ^a   Bossios, A ^a   Alm, A S ^a   Jeurink, P ^a   Lu, Y ^a   Malmhall C ^a   Sjostrand M ^a   Lotvall J ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Bone marrow; Eosinophilopoiesis; Progenitor cells; T cells

Indexed keywords

ALLERGEN; BROXURIDINE; EOTAXIN; INTERLEUKIN 5; OVALBUMIN; SODIUM CHLORIDE;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BONE MARROW EOSINOPHILOPOIESIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LABELING; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; FLOW CYTOMETRY; HEMATOPOIESIS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ALLERGENS; ANIMALS; ANTIGENS, CD34; ANTIGENS, CD4; ANTIGENS, CD45; ANTIGENS, CD8; BONE MARROW CELLS; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL24; EOSINOPHILS; LEUKOPOIESIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN;

EID: 35748972926     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2007.01509.x     Document Type: Article

References (32)

1. Wood LJ, Inman MD, Watson RM, Foley R, Denburg JA, O'Byrne PM. Changes in bone marrow inflammatory cell progenitors after inhaled allergen in asthmatic subjects. Am J Respir Crit Care Med 1998 157 : 99 105.
2. Sehmi R, Howie K, Sutherland DR, Schragge W, O'Byrne PM, Denburg JA. Increased levels of CD34+ hemopoietic progenitor cells in atopic subjects. Am J Respir Cell Mol Biol 1996 15 : 645 655.
3. Woolley MJ, Denburg JA, Ellis R, Dahlback M, O'Byrne PM. Allergen- induced changes in bone marrow progenitors and airway responsiveness in dogs and the effect of inhaled budesonide on these parameters. Am J Respir Cell Mol Biol 1994 11 : 600 606.
4. Sehmi R, Wood LJ, Watson R, Foley R, Hamid Q, O'Byrne PM et al. Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow- derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. J Clin Invest 1997 100 : 2466 2475.
5. Gaspar Elsas MI, Joseph D, Elsas PX, Vargaftig BB. Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge. Am J Respir Cell Mol Biol 1997 17 : 404 413.
6. Ohkawara Y, Lei XF, Stampfli MR, Marshall JS, Xing Z, Jordana M. Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation. Am J Respir Cell Mol Biol 1997 16 : 510 520.
7. Tomaki M, Zhao LL, Lundahl J, Sjostrand M, Jordana M, Linden A et al. Eosinophilopoiesis in a murine model of allergic airway eosinophilia: involvement of bone marrow IL-5 and IL-5 receptor alpha. J Immunol 2000 165 : 4040 4050.
8. Minshall EM, Schleimer R, Cameron L, Minnicozzi M, Egan RW, Gutierrez-Ramos JC et al. Interleukin-5 expression in the bone marrow of sensitized Balb/c mice after allergen challenge. Am J Respir Crit Care Med 1998 158 : 951 957.
9. Inman MD, Denburg JA, Ellis R, Dahlback M, O'Byrne PM. Allergen-induced increase in bone marrow progenitors in airway hyperresponsive dogs: regulation by a serum hemopoietic factor. Am J Respir Cell Mol Biol 1996 15 : 305 311.
10. Koury MJ. Programmed cell death (apoptosis) in hematopoiesis. Exp Hematol 1992 20 : 391 394.
11. Fairbairn LJ, Cowling GJ, Reipert BM, Dexter TM. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 1993 74 : 823 832.
12. Johansson AK, Sjostrand M, Tomaki M, Samulesson AM, Lotvall J. Allergen stimulates bone marrow CD34(+) cells to release IL-5 in vitro; a mechanism involved in eosinophilic inflammation? Allergy 2004 59 : 1080 1086.
13. Yamaguchi Y, Suda T, Suda J, Eguchi M, Miura Y, Harada N et al. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J Exp Med 1988 167 : 43 56.
14. Wood LJ, Sehmi R, Dorman S, Hamid Q, Tulic MK, Watson RM et al. Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma. Am J Respir Crit Care Med 2002 166 : 883 889.
15. Radinger M, Sergejeva S, Johansson AK, Malmhall C, Bossios A, Sjostrand M et al. Regulatory role of CD8+ T lymphocytes in bone marrow eosinophilopoiesis. Respir Res 2006 7 : 83.
16. Hogan MB, Weissman DN, Hubbs AF, Gibson LF, Piktel D, Landreth KS. Regulation of eosinophilopoiesis in a murine model of asthma. J Immunol 2003 171 : 2644 2651.
17. Larson KA, Horton MA, Madden BJ, Gleich GJ, Lee NA, Lee JJ. The identification and cloning of a murine major basic protein gene expressed in eosinophils. J Immunol 1995 155 : 3002 3012.
18. Al-Rabia MW, Blaylock MG, Sexton DW, Thomson L, Walsh GM. Granule protein changes and membrane receptor phenotype in maturing human eosinophils cultured from CD34+ progenitors. Clin Exp Allergy 2003 33 : 640 648.
19. Hogan MB, Piktel D, Landreth KS. IL-5 production by bone marrow stromal cells: implications for eosinophilia associated with asthma. J Allergy Clin Immunol 2000 106 : 329 336.
20. Wang J, Palmer K, Lotvall J, Milan S, Lei XF, Matthaei KI et al. Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia. J Clin Invest 1998 102 : 1132 1141.
21. Lamkhioued B, Abdelilah SG, Hamid Q, Mansour N, Delespesse G, Renzi PM. The CCR3 receptor is involved in eosinophil differentiation and is up-regulated by Th2 cytokines in CD34+ progenitor cells. J Immunol 2003 170 : 537 547.
22. Sehmi R, Dorman S, Baatjes A, Watson R, Foley R, Ying S et al. Allergen- induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Immunology 2003 109 : 536 546.
23. Southam DS, Widmer N, Ellis R, Hirota JA, Inman MD, Sehmi R. Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged mice. J Allergy Clin Immunol 2005 115 : 95 102.
24. Sitkauskiene B, Johansson AK, Sergejeva S, Lundin S, Sjostrand M, Lotvall J. Regulation of bone marrow and airway CD34+ eosinophils by interleukin-5. Am J Respir Cell Mol Biol 2004 30 : 367 378.
25. Menzies-Gow A, Flood-Page P, Sehmi R, Burman J, Hamid Q, Robinson DS et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol 2003 111 : 714 719.
26. Koo GC, Shah K, Ding GJ, Xiao J, Wnek R, Doherty G et al. A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation. Am J Respir Crit Care Med 2003 167 : 1400 1409.
27. Okigami H, Takeshita K, Tajimi M, Komura H, Albers M, Lehmann TE et al. Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4. Eur J Pharmacol 2007 559 : 202 209.
28. Ravensberg AJ, Luijk B, Westers P, Hiemstra PS, Sterk PJ, Lammers JW et al. The effect of a single inhaled dose of a VLA-4 antagonist on allergen-induced airway responses and airway inflammation in patients with asthma. Allergy 2006 61 : 1097 1103.
29. Miyahara N, Takeda K, Miyahara S, Taube C, Joetham A, Koya T et al. Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness. J Immunol 2005 174 : 4979 4984.
30. Miyahara N, Swanson BJ, Takeda K, Taube C, Miyahara S, Kodama T et al. Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness. Nat Med 2004 10 : 865 869.
31. Crosby JR, Shen HH, Borchers MT, Justice JP, Ansay T, Lee JJ et al. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment. Am J Physiol Lung Cell Mol Physiol 2002 282 : L99 L108.
32. Radinger M, Johansson AK, Sitkauskiene B, Sjostrand M, Lotvall J. Eotaxin-2 regulates newly produced and CD34 airway eosinophils after allergen exposure. J Allergy Clin Immunol 2004 113 : 1109 1116.