메뉴 건너뛰기




Volumn 195, Issue 2, 2007, Pages 265-272

A role for mu opioid receptors in cocaine-induced activity, sensitization, and reward in the rat

Author keywords

Behavioral sensitization; Cocaine; Conditioned place preference; CTAP; Endorphin; Enkephalin; Opioids; Psychostimulant; Rat; Reward

Indexed keywords

COCAINE; ENDORPHIN; MU OPIATE RECEPTOR ANTAGONIST;

EID: 35748935214     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0883-z     Document Type: Article
Times cited : (28)

References (55)
  • 2
    • 3042735747 scopus 로고    scopus 로고
    • Ultrastructural evidence for co-localization of dopamine D2 and mu-opioid receptors in the rat dorsolateral striatum
    • Ambrose LM, Unterwald EM, Van Bockstaele EJ (2004) Ultrastructural evidence for co-localization of dopamine D2 and mu-opioid receptors in the rat dorsolateral striatum. Anat Rec 279:583-591
    • (2004) Anat Rec , vol.279 , pp. 583-591
    • Ambrose, L.M.1    Unterwald, E.M.2    Van Bockstaele, E.J.3
  • 4
    • 0023153146 scopus 로고
    • Naloxone attenuation of the effect of cocaine on rewarding brain stimulation
    • Bain GT, Kornetsky C (1987) Naloxone attenuation of the effect of cocaine on rewarding brain stimulation. Life Sci 40:1119-1125
    • (1987) Life Sci , vol.40 , pp. 1119-1125
    • Bain, G.T.1    Kornetsky, C.2
  • 5
    • 0030614830 scopus 로고    scopus 로고
    • Selective sensitization to the psychosis-inducing effects of cocaine: A possible marker for addiction relapse vulnerability
    • Bartlett E, Hallin A, Chapman B, Angrist B (1997) Selective sensitization to the psychosis-inducing effects of cocaine: a possible marker for addiction relapse vulnerability. Neuropsychopharmacology 16:77-82
    • (1997) Neuropsychopharmacology , vol.16 , pp. 77-82
    • Bartlett, E.1    Hallin, A.2    Chapman, B.3    Angrist, B.4
  • 6
    • 0026541025 scopus 로고
    • Opioidergic modulation of cocaine conditioned place preference
    • Bilsky EJ, Montegut MJ, Delong CL, Reid LD (1992) Opioidergic modulation of cocaine conditioned place preference. Life Sci 50:PL85-PL90
    • (1992) Life Sci , vol.50
    • Bilsky, E.J.1    Montegut, M.J.2    Delong, C.L.3    Reid, L.D.4
  • 7
    • 0031438292 scopus 로고    scopus 로고
    • Naltrexone, naltrindole, and CTOP block cocaine-induced sensitization to seizures and death
    • 8
    • Braida D, Paladini E, Gori E, Sala M (1997) Naltrexone, naltrindole, and CTOP block cocaine-induced sensitization to seizures and death. Peptides 18(8):1189-1195
    • (1997) Peptides , vol.18 , pp. 1189-1195
    • Braida, D.1    Paladini, E.2    Gori, E.3    Sala, M.4
  • 8
    • 0025806205 scopus 로고
    • Opiate antagonists reduce cocaine but not nicotine self-administration
    • 2
    • Corrigall WA, Coen KM (1991) Opiate antagonists reduce cocaine but not nicotine self-administration. Psychopharmacology (Berl) 104(2):167-170
    • (1991) Psychopharmacology (Berl) , vol.104 , pp. 167-170
    • Corrigall, W.A.1    Coen, K.M.2
  • 9
    • 0036584948 scopus 로고    scopus 로고
    • Psychomotor stimulant addiction: A neuronal systems perspective
    • Everitt BJ, Wolf ME (2002) Psychomotor stimulant addiction: a neuronal systems perspective. J Neurosci 22:3312-3320
    • (2002) J Neurosci , vol.22 , pp. 3312-3320
    • Everitt, B.J.1    Wolf, M.E.2
  • 10
    • 1842855964 scopus 로고    scopus 로고
    • Mu-opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion
    • Hall FS, Goeb M, Li XF, Sora I, Uhl GR (2004) Mu-opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion. Mol Brain Res 121:123-130
    • (2004) Mol Brain Res , vol.121 , pp. 123-130
    • Hall, F.S.1    Goeb, M.2    Li, X.F.3    Sora, I.4    Uhl, G.R.5
  • 11
    • 0024502533 scopus 로고
    • Cocaine alters opiate receptor binding in critical brain reward regions
    • 1
    • Hammer RP (1989) Cocaine alters opiate receptor binding in critical brain reward regions. Synapse 3(1):55-60
    • (1989) Synapse , vol.3 , pp. 55-60
    • Hammer, R.P.1
  • 12
    • 0016796696 scopus 로고
    • Studies on the distinction between uptake inhibition and release of [3H]dopamine in rat brain tissue slices
    • Heikkila RE, Orlansky H, Cohen G (1975) Studies on the distinction between uptake inhibition and release of [3H]dopamine in rat brain tissue slices. Biochem Pharmacol 24:847-852
    • (1975) Biochem Pharmacol , vol.24 , pp. 847-852
    • Heikkila, R.E.1    Orlansky, H.2    Cohen, G.3
  • 13
    • 0016133734 scopus 로고
    • Binding of 3H-naloxone in the mouse brain: Effect of ions and tolerance development
    • 12
    • Hitzemann RJ, Hitzemann BA, Loh HH (1974) Binding of 3H-naloxone in the mouse brain: effect of ions and tolerance development. Life Sci 14(12):2393-2404
    • (1974) Life Sci , vol.14 , pp. 2393-2404
    • Hitzemann, R.J.1    Hitzemann, B.A.2    Loh, H.H.3
  • 15
    • 0024448814 scopus 로고
    • Opioid mediation of cocaine-induced hyperactivity and reinforcement
    • Houdi AA, Bardo MT, VanLoon GR (1989) Opioid mediation of cocaine-induced hyperactivity and reinforcement. Brain Res 497:195-198
    • (1989) Brain Res , vol.497 , pp. 195-198
    • Houdi, A.A.1    Bardo, M.T.2    Vanloon, G.R.3
  • 16
    • 1642543988 scopus 로고    scopus 로고
    • Genetic and pharmacological manipulation of mu opioid receptor in mice reveals a differential effect on behavioral sensitization to cocaine
    • Hummel M, Ansonoff AM, Pintar JE, Unterwald EM (2004) Genetic and pharmacological manipulation of mu opioid receptor in mice reveals a differential effect on behavioral sensitization to cocaine. Neuroscience 125:211-220
    • (2004) Neuroscience , vol.125 , pp. 211-220
    • Hummel, M.1    Ansonoff, A.M.2    Pintar, J.E.3    Unterwald, E.M.4
  • 17
    • 33748787123 scopus 로고    scopus 로고
    • An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice
    • Hummel M, Schroeder JA, Liu-Chen LY, Cowan A, Unterwald EM (2006) An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. Neuroscience 142:481-491
    • (2006) Neuroscience , vol.142 , pp. 481-491
    • Hummel, M.1    Schroeder, J.A.2    Liu-Chen, L.Y.3    Cowan, A.4    Unterwald, E.M.5
  • 18
    • 0026497458 scopus 로고
    • Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides
    • Hurd YL, Herkenham M (1992) Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides. Mol Brain Res 16:97-104
    • (1992) Mol Brain Res , vol.16 , pp. 97-104
    • Hurd, Y.L.1    Herkenham, M.2
  • 19
    • 0030027553 scopus 로고    scopus 로고
    • Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens
    • 1-2
    • Izenwasser S, Heller B, Cox BM (1996) Continuous cocaine administration enhances mu- but not delta-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens. Eur J Pharmacol 297(1-2):187-191
    • (1996) Eur J Pharmacol , vol.297 , pp. 187-191
    • Izenwasser, S.1    Heller, B.2    Cox, B.M.3
  • 21
    • 0030756351 scopus 로고    scopus 로고
    • Drug abuse: Hedonic homeostatic dysregulation
    • Koob GF, Le Moal M (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278:52-58
    • (1997) Science , vol.278 , pp. 52-58
    • Koob, G.F.1    Le Moal, M.2
  • 23
    • 12344328423 scopus 로고    scopus 로고
    • Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice
    • 2
    • Lesscher HM, Hordijk M, Bondar NP, Alekseyenko OV, Burbach JP, van Ree JM, Gerrits MA (2005) Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice. Neuropsychopharmacology 30(2):278-285
    • (2005) Neuropsychopharmacology , vol.30 , pp. 278-285
    • Lesscher, H.M.1    Hordijk, M.2    Bondar, N.P.3    Alekseyenko, O.V.4    Burbach, J.P.5    Van Ree, J.M.6    Gerrits, M.A.7
  • 24
    • 0023277101 scopus 로고
    • Naltrexone and dysphoria: A double-blind placebo controlled trial
    • Malcolm R, O'Neil PM, Von JM, Dickerson PC (1987) Naltrexone and dysphoria: a double-blind placebo controlled trial. Biol Psychiatry 22:710-716
    • (1987) Biol Psychiatry , vol.22 , pp. 710-716
    • Malcolm, R.1    O'Neil, P.M.2    Von, J.M.3    Dickerson, P.C.4
  • 25
    • 0023390553 scopus 로고
    • Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain
    • Mansour A, Khachaturian H, Lewis ME, Akil H, Watson SJ (1987) Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J Neurosci 7:2445-2464
    • (1987) J Neurosci , vol.7 , pp. 2445-2464
    • Mansour, A.1    Khachaturian, H.2    Lewis, M.E.3    Akil, H.4    Watson, S.J.5
  • 26
    • 33747175340 scopus 로고    scopus 로고
    • Reduced psychostimulant effects on dopamine dynamics in the nucleus accumbens of mu-opioid receptor knockout mice
    • Mathon DS, Vanderschuren LJ, Ramakers GM (2006) Reduced psychostimulant effects on dopamine dynamics in the nucleus accumbens of mu-opioid receptor knockout mice. Neuroscience 141:1679-1684
    • (2006) Neuroscience , vol.141 , pp. 1679-1684
    • Mathon, D.S.1    Vanderschuren, L.J.2    Ramakers, G.M.3
  • 27
    • 0021836650 scopus 로고
    • Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central beta-endorphin
    • Mucha RF, Millan MJ, Herz A (1985) Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central beta-endorphin. Psychopharmacology 86:281-247
    • (1985) Psychopharmacology , vol.86 , pp. 281-247
    • Mucha, R.F.1    Millan, M.J.2    Herz, A.3
  • 28
    • 0035654631 scopus 로고    scopus 로고
    • Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine
    • Olive MF, Koenig HN, Nannini MA, Hodge CW (2001) Stimulation of endorphin neurotransmission in the nucleus accumbens by ethanol, cocaine, and amphetamine. J Neurosci 21:RC184
    • (2001) J Neurosci , vol.21 , pp. 184
    • Olive, M.F.1    Koenig, H.N.2    Nannini, M.A.3    Hodge, C.W.4
  • 29
    • 0023028494 scopus 로고
    • Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors
    • 11
    • Pelton JT, Kazmierski W, Gulya K, Yamamura HI, Hruby VJ (1986) Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem 29(11):2370-2375
    • (1986) J Med Chem , vol.29 , pp. 2370-2375
    • Pelton, J.T.1    Kazmierski, W.2    Gulya, K.3    Yamamura, H.I.4    Hruby, V.J.5
  • 30
    • 0017255148 scopus 로고
    • Increasing effects of receptive cocaine administration in the rat
    • Post R, Rose H (1976) Increasing effects of receptive cocaine administration in the rat. Nature 260:731-732
    • (1976) Nature , vol.260 , pp. 731-732
    • Post, R.1    Rose, H.2
  • 31
    • 0037044702 scopus 로고    scopus 로고
    • Effects of the selective mu(1)-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats
    • Rademacher DJ, Steinpreis RE (2002) Effects of the selective mu(1)-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats. Neurosci Lett 332:159-162
    • (2002) Neurosci Lett , vol.332 , pp. 159-162
    • Rademacher, D.J.1    Steinpreis, R.E.2
  • 32
    • 0023265754 scopus 로고
    • Cocaine receptors on dopamine transporters are related to self-administration of cocaine
    • Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219-1223
    • (1987) Science , vol.237 , pp. 1219-1223
    • Ritz, M.C.1    Lamb, R.J.2    Goldberg, S.R.3    Kuhar, M.J.4
  • 33
    • 0027305458 scopus 로고
    • The neural basis of drug craving: An incentive-sensitization theory of addiction
    • Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247-291
    • (1993) Brain Res Rev , vol.18 , pp. 247-291
    • Robinson, T.E.1    Berridge, K.C.2
  • 35
    • 1642387528 scopus 로고    scopus 로고
    • Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice
    • Sakoori K, Murphy NP (2004) Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice. Psychopharmacology (Berl) 172:129-136
    • (2004) Psychopharmacology (Berl) , vol.172 , pp. 129-136
    • Sakoori, K.1    Murphy, N.P.2
  • 36
    • 0035804515 scopus 로고    scopus 로고
    • Naltrexone and relapse prevention treatment for cocaine-dependent patients
    • 2
    • Schmitz JM, Stotts AL, Rhoades HM, Grabowski J (2001) Naltrexone and relapse prevention treatment for cocaine-dependent patients. Addict Behav 26(2):167-180
    • (2001) Addict Behav , vol.26 , pp. 167-180
    • Schmitz, J.M.1    Stotts, A.L.2    Rhoades, H.M.3    Grabowski, J.4
  • 38
    • 0028897859 scopus 로고
    • Involvement of the mesolimbic dopamine system in mediating the aversive effects of opioid antagonists in the rat
    • Shippenberg TS, Bals-Kubik R (1995a) Involvement of the mesolimbic dopamine system in mediating the aversive effects of opioid antagonists in the rat. Behav Pharmacol 6:99-105
    • (1995) Behav Pharmacol , vol.6 , pp. 99-105
    • Shippenberg, T.S.1    Bals-Kubik, R.2
  • 39
    • 0029075885 scopus 로고
    • Sensitization to the conditioned rewarding effects of cocaine: Pharmacological and temporal characteristics
    • 2
    • Shippenberg TS, Heidbreder C (1995b) Sensitization to the conditioned rewarding effects of cocaine: pharmacological and temporal characteristics. J Pharmacol Exp Ther 273(2):808-815
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 808-815
    • Shippenberg, T.S.1    Heidbreder, C.2
  • 40
    • 32844470518 scopus 로고    scopus 로고
    • Constitutively active mu opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice
    • Shoblock JR, Maidment NT (2006) Constitutively active mu opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice. Neuropsychopharmacology 31:171-177
    • (2006) Neuropsychopharmacology , vol.31 , pp. 171-177
    • Shoblock, J.R.1    Maidment, N.T.2
  • 41
  • 42
    • 0026559951 scopus 로고
    • Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway
    • Spanagel R, Herz A, Shippenberg TS (1992) Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 89:2046-2050
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2046-2050
    • Spanagel, R.1    Herz, A.2    Shippenberg, T.S.3
  • 43
    • 0027327238 scopus 로고
    • 'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen
    • 4
    • Spangler R, Unterwald EM, Kreek MJ (1993) 'Binge' cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Mol Brain Res 19(4):323-327
    • (1993) Mol Brain Res , vol.19 , pp. 323-327
    • Spangler, R.1    Unterwald, E.M.2    Kreek, M.J.3
  • 44
    • 0031760312 scopus 로고    scopus 로고
    • Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior
    • 1-2
    • Steiner H, Gerfen CR (1998) Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior. Exp Brain Res 123(1-2):60-76
    • (1998) Exp Brain Res , vol.123 , pp. 60-76
    • Steiner, H.1    Gerfen, C.R.2
  • 45
    • 0026639243 scopus 로고
    • The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference
    • Suzuki T, Shiozaki Y, Masukawa Y, Misawa M, Nagase H (1992) The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference. Jpn J Pharmacol 58:435-442
    • (1992) Jpn J Pharmacol , vol.58 , pp. 435-442
    • Suzuki, T.1    Shiozaki, Y.2    Masukawa, Y.3    Misawa, M.4    Nagase, H.5
  • 46
    • 0028000424 scopus 로고
    • The role of delta-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences
    • Suzuki T, Mori T, Tsuji M, Misawa M, Nagase H (1994) The role of delta-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences. Life Sci 55:339-344
    • (1994) Life Sci , vol.55 , pp. 339-344
    • Suzuki, T.1    Mori, T.2    Tsuji, M.3    Misawa, M.4    Nagase, H.5
  • 47
    • 0018268307 scopus 로고
    • Enhance analgesic effects of morphine after chronic administration of naloxone in the rat
    • Tang AH, Collins RJ (1978) Enhance analgesic effects of morphine after chronic administration of naloxone in the rat. Eur J Pharmacol 47:473-474
    • (1978) Eur J Pharmacol , vol.47 , pp. 473-474
    • Tang, A.H.1    Collins, R.J.2
  • 48
    • 0028110978 scopus 로고
    • Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors
    • Unterwald EM, Rubenfeld JM, Kreek MJ (1994) Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors. NeuroReport 5:1613-1616
    • (1994) NeuroReport , vol.5 , pp. 1613-1616
    • Unterwald, E.M.1    Rubenfeld, J.M.2    Kreek, M.J.3
  • 49
    • 0029155486 scopus 로고
    • Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels
    • 2
    • Unterwald EM, Rubenfeld JM, Imai Y, Wang JB, Uhl GR, Kreek MJ (1995) Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels. Mol Brain Res 33(2):351-355
    • (1995) Mol Brain Res , vol.33 , pp. 351-355
    • Unterwald, E.M.1    Rubenfeld, J.M.2    Imai, Y.3    Wang, J.B.4    Uhl, G.R.5    Kreek, M.J.6
  • 50
    • 0021348060 scopus 로고
    • Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: Biochemical and behavioral correlates
    • Volterra BN, DiGiulio AM, Cuomo V, Racagni G (1984) Modulation of opioid system in C57 mice after repeated treatment with morphine and naloxone: biochemical and behavioral correlates. Life Sci 34:1669-1678
    • (1984) Life Sci , vol.34 , pp. 1669-1678
    • Volterra, B.N.1    Digiulio, A.M.2    Cuomo, V.3    Racagni, G.4
  • 51
    • 0034972443 scopus 로고    scopus 로고
    • Inverse agonists and neutral antagonists at mu opioid receptor (MOR): Possible role of basal receptor signaling in narcotic dependence
    • Wang D, Raehal KM, Bilsky EJ, Sadee W (2001) Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. J Neurochem 77:1590-1600
    • (2001) J Neurochem , vol.77 , pp. 1590-1600
    • Wang, D.1    Raehal, K.M.2    Bilsky, E.J.3    Sadee, W.4
  • 52
    • 22044457008 scopus 로고    scopus 로고
    • Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat
    • 3
    • White DA, Hwang ML, Holtzman SG (2005) Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat. Pharmacol Biochem Behav 81(3):451-458
    • (2005) Pharmacol Biochem Behav , vol.81 , pp. 451-458
    • White, D.A.1    Hwang, M.L.2    Holtzman, S.G.3
  • 54
    • 0038359291 scopus 로고    scopus 로고
    • Differential effects of morphine and cocaine on locomotor activity and sensitization in mu-opioid receptor knockout mice
    • Yoo JH, Yang EM, Lee SY, Loh HH, Ho IK, Jang CG (2003) Differential effects of morphine and cocaine on locomotor activity and sensitization in mu-opioid receptor knockout mice. Neurosci Lett 344:37-40
    • (2003) Neurosci Lett , vol.344 , pp. 37-40
    • Yoo, J.H.1    Yang, E.M.2    Lee, S.Y.3    Loh, H.H.4    Ho, I.K.5    Jang, C.G.6
  • 55
    • 0029906096 scopus 로고    scopus 로고
    • Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving
    • Zubieta JK, Gorelick DA, Stauffer R, Ravert HT, Dannals RF, Frost JJ (1996) Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving. Nat Med 2:1225-1229
    • (1996) Nat Med , vol.2 , pp. 1225-1229
    • Zubieta, J.K.1    Gorelick, D.A.2    Stauffer, R.3    Ravert, H.T.4    Dannals, R.F.5    Frost, J.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.