Dynamic Basis for One-Dimensional DNA Scanning by the Mismatch Repair Complex Msh2-Msh6

Molecular Cell

Volumn 28, Issue 3, 2007, Pages 359-370

  Gorman, Jason ^a   Chowdhury, Arindam ^a   Surtees, Jennifer A ^b   Shimada, Jun ^a   Reichman, David R ^a   Alani, Eric ^b   Greene, Eric C ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

DNA

Indexed keywords

DNA; PROTEIN MSH2; PROTEIN MSH6;

ARTICLE; MISMATCH REPAIR; PROTEIN INTERACTION; PROTEIN SECRETION; SCANNING ELECTRON MICROSCOPY;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; DNA MISMATCH REPAIR; DNA, FUNGAL; DNA-BINDING PROTEINS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MUTS HOMOLOG 2 PROTEIN; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 35649018595     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.09.008     Document Type: Article

References (41)

1. Allen D.J., Makhov A., Griley M., Taylor J., Thresher R., Modrich P., and Griffith J.D. MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J. 16 (1997) 4467-4476
2. Ban C., Junop M., and Yang W. Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair. Cell 97 (1999) 85-97
3. Berg H.C. Random Walks in Biology, Expanded Edition (1993), Princeton University Press, Princeton, NJ
4. Berg O.G., Winter R.B., and von Hippel P.H. Diffusion-driven mechanisms of protein translocation on nucleic acids. Biochemistry 20 (1981) 6929-6948
5. Blackwell L.J., Martik D., Bjornson K.P., Bjornson E.S., and Modrich P. Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism. J. Biol. Chem. 273 (1998) 32055-32062
6. Blackwell L.J., Bjornson K.P., Allen D.J., and Modrich P. Distinct MutS DNA-binding modes that are differentially modulated by ATP binding and hydrolysis. J. Biol. Chem. 276 (2001) 34339-34347
7. Blainey P.C., van Oijen A.M., Banerjee A., Verdine G.L., and Xie X.S. A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc. Natl. Acad. Sci. USA 103 (2006) 5752-5757
8. Fortune J.M., Pavlov Y.I., Welch C.M., Johansson E., Burgers P.M.J., and Kunkel T.A. Saccharomyces cerevisiae DNA polymerase δ. J. Biol. Chem. 280 (2005) 29980-29987
9. Gasser R., Koller T., and Sogo J.M. The stability of nucleosomes at the replication fork. J. Mol. Biol. 258 (1996) 224-239
10. Gerland U., Moroz J.D., and Hwa T. Physical constraints and functional characteristics of transcription factor-DNA interaction. Proc. Natl. Acad. Sci. USA 99 (2002) 12015-12020
11. Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., and Weissman J.S. Global analysis of protein expression in yeast. Nature 425 (2003) 737-741
12. Gradia S., Subramanian D., Wilson T., Acharya S., Makhov A., Griffith J.D., and Fishel R. hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA. Mol. Cell 3 (1999) 255-261
13. Graneli A., Yeykal C.C., Robertson R.B., and Greene E.C. Long-distance lateral diffusion of human Rad51 on double-stranded DNA. Proc. Natl. Acad. Sci. USA 103 (2006) 1221-1226
14. Halford S.E., and Marko J.F. How do site-specific DNA-binding proteins find their targets?. Nucleic Acids Res. 32 (2004) 3040-3052
15. Hsieh P. Molecular mechanisms of DNA mismatch repair. Mutat. Res. 486 (2001) 71-87
16. Jacobs-Palmer E., and Hingorani M.M. The effects of nucleotides on MutS-DNA binding kinetics clarify the role of MutS ATPase activity in mismatch repair. J. Mol. Biol. 366 (2007) 1087-1098
17. Jiang J., Bai L., Surtees J.A., Zekeriyya G., Wang M.D., and Alani E. Detection of high-affinity and sliding clamp modes for Msh2-Msh6 by single-molecule unzipping force analysis. Mol. Cell 20 (2005) 771-781
18. Jiricny J. The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol. 7 (2006) 335-346
19. Kampmann M. Facilitated diffusion in chromatin lattices: mechanistic diversity and regulatory potential. Mol. Microbiol. 57 (2005) 889-899
20. Kleczkowska H.E., Marra G., Lettieri T., and Jiricny J. hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci. Genes Dev. 15 (2001) 724-736
21. Kunkel T.A. DNA replication fidelity. J. Biol. Chem. 279 (2004) 16895-16898
22. Kunkel T.A., and Erie D.A. DNA mismatch repair. Annu. Rev. Biochem. 74 (2005) 681-710
23. Lahue R.S., Au K.G., and Modrich P. DNA mismatch correction in a defined system. Science 245 (1989) 160-164
24. Lamers M., Perrakis A., Enzlin J.H., Winterwerp H.H.K., de Wind N., and Sixma T.K. The crystal structure of DNA mismatch repair protein MutS binding to a G-T mismatch. Nature 407 (2000) 711-717
25. Mazur D.J., Mendillo M.L., and Kolodner R.D. Inhibition of Msh6 ATPase activity by mispaired DNA induces a Msh2(ATP)-Msh6(ATP) state capable of hydrolysis independent movement along DNA. Mol. Cell 22 (2006) 39-49
26. Mendillo M.L., Mazur D.J., and Kolodner R.D. Analysis of the interaction between the Saccharomyces cerevisiae MSH2-MSH6 and MLH1-PMS1 complexes with DNA using a reversible end-blocking system. J. Biol. Chem. 280 (2005) 22245-22257
27. Modrich P. Mechanisms in eukaryotic mismatch repair. J. Biol. Chem. 281 (2006) 30305-30309
28. Modrich P., and Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65 (1996) 101-133
29. Obmolova G., Ban C., Hsieh P., and Yang W. Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature 407 (2000) 703-710
30. Pluciennik A., and Modrich P. Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair. Proc. Natl. Acad. Sci. USA 104 (2007) 12709-12713
31. Qian H., Sheetz M.P., and Elson E.L. Single particle tracking. Biophys. J. 60 (1991) 910-921
32. Schurr J.M. The one-dimensional diffusion coefficient of proteins absorbed on DNA. Hydrodynamic considerations. Biophys. Chem. 9 (1979) 413-414
33. Slutsky M., and Mirny L.A. Kinetics of protein-DNA interaction: facilitated target location in sequence-dependent potential. Biophys. J. 87 (2004) 4021-4035
34. Spolar R.S., and Record M.T. Coupling of local folding to site-specific binding of proteins to DNA. Science 263 (1994) 777-784
35. Umar A., Buermeyer A.B., Simon J.A., Thomas D.C., Clark A.B., Liskay R.M., and Kunkel T.A. Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell 87 (1996) 65-73
36. Vlahovicek K., Kajan L., and Ponor S. DNA analysis servers: plot.it, bend.it, model.it and IS. Nucleic Acids Res. 31 (2003) 3686-3687
37. von Hippel P.H., and Berg O.G. Facilitated target location in biological systems. J. Biol. Chem. 264 (1989) 675-678
38. Wang H., Yang Y., Schofield M.J., Du C., Fridman Y., Lee S.D., Larson E.D., Drummond J.T., Alani E., Hsieh P., and Erie D.A. DNA bending and unbending by MutS govern mismatch recognition and specificity. Proc. Natl. Acad. Sci. USA 100 (2003) 14822-14827
39. Warren J.J., Pohlhaus T.J., Changela A., Iyer R.R., Modrich P.L., and Bease L.S. Structure of the human MutSα DNA lesion recognition complex. Mol. Cell 26 (2007) 579-592
40. Yang W. Poor base stacking at DNA lesions may initiate recognition by many repair proteins. DNA Repair (Amst.) 10 (2006) 654-666
41. Yang Y., Sass L.E., Du C., Hsieh P., and Erie D.H. Determination of protein DNA binding constants and specificities from statistical analysis of single molecules: MutS-DNA interactions. Nucleic Acids Res. 33 (2005) 39-49