Effect of repeated low-dose organophosphorothionate pesticide exposure on digoxin pharmacokinetics in rats; a possible interaction involving P-glycoprotein

Toxicology Mechanisms and Methods

Volumn 17, Issue 8, 2007, Pages 459-466

  Cem, Kaplan Yusuf ^a   Kubilay, Oransay ^a   Ozlem, Eminoglu ^b   Hulya, Ellidokuz ^a   Ayse, Gelal ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b Actavis Group   (Iceland)

Author keywords

Digoxin Pharmacokinetics; Organophosphorothionate Pesticides; P Glycoprotein

Indexed keywords

DIGOXIN; GLYCOPROTEIN P; ORGANOPHOSPHOROTHIONATE; PESTICIDE; TAP WATER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BILE; BILIARY EXCRETION; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; FEMALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; URINE;

RATTUS; RATTUS NORVEGICUS;

EID: 35649009480     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510701190755     Document Type: Article

References (22)

1. Aiba, T., Yoshinaga, M., Ishida, K., Takehara, Y., and Hashimoto, Y. 2005. Intestinal expression and metabolic activity of the CYP3A subfamily in female rats. Biol. Pharm. Bull. 28:311-315.
2. Bain, L. J., and LeBlanc, G. A. 1996. Interaction of structurally diverse pesticides with the human MDR1 gene product P-glycoprotein. Toxicol. Appl. Pharmacol. 141:288-298.
3. Balayssac, D., Authier, N., Cayre, A., and Coudore, F. 2005. Does inhibition of P-glycoprotein lead to drug-drug interactions?. Toxicol. Lett. 156:319-329.
4. Braunschweig, J., Staubli, M., and Studer, H. 1987. Interactions of amiodarone with digoxin in rats. Br. J. Pharmacol. 92:553-559.
5. De Lannoy, I. A., Koren, G., Klein, J., Charuk, J., and Silverman, M. 1992. Cyclosporin and quinidine inhibition of renal digoxin excretion: evidence for luminal secretion of digoxin. Am. J. Physiol. 263:613-622.
6. De Lannoy, I. A., and Silverman, M. 1992. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochem. Biophys. Res. Commun. 189:551-557.
7. Ding, R., Tayrouz, Y., Riedel, K. D., Burhenne, J., Weiss, J., Mikus, G., and Haefeli, W. E. 2004. Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers. Clin. Pharmacol. Ther. 76:73-84.
8. Fromm, M. F., Kim, R. B., Stein, C. M., Wilkinson, G. R., and Roden, D. M. 1999. Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 99:552-557.
9. Funakoshi, S., Murakami, T., Yumoto, R., Kiribayashi, Y., and Takano, M. 2003. Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats. J. Pharm. Sci. 92:1455-1463.
10. Gelal, A., Gumustekin, M., Kalkan, S., Guven, H., and Eminoglu, O. 2001. Effects of subchronic parathion exposure on cyclosporine pharmacokinetics in rats. J. Toxicol. Environ. Health. Part A 62:289-294.
11. Lanning, C. L., Fine, R. L., Sachs, C. W., Rao, U. S., Corcoran, J. J., and Abou-Donia, M. B. 1996. Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein. J. Toxicol. Environ. Health 47:395-407.
12. Lecoeur, S., Videmann, B., and Mazallon, M. 2006. Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein. Toxicol. Lett. 161:200-209.
13. Matheny, C. J., Lamb, M. W., Brouwer, K. R., and Pollack, G. M. 2001. Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation. Pharmacotherapy 21:778-796.
14. Mayer, U., Wagenaar, E., Beijnen, J. H., Smit, J. W., Meijer, D. K., van Asperen, J., Borst, P., and Schinkel, A. H. 1996. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein. Br. J. Pharmacol. 119:1038-1044.
15. Okamura, N., Hirai, M., Tanigawara, Y., Tanaka, K., Yasuhara, M., Ueda, K., Komano, T., and Hori, R. 1993. Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney. J. Pharmacol. Exp. Ther. 266:1614-1619.
16. Salphati, L., and Benet, L. Z. 1998. Effects of ketoconazole on digoxin absorption and disposition in rat. Pharmacology. 56:308-313.
17. Salphati, L., and Benet, L. 1999. Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A. Xenobiotica. 29:171-185.
18. Song, S., Suzuki, H., Kawai, R., and Sugiyama, Y. 1999. Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats. Drug. Metab. Dispos. 27:689-694.
19. Su, S. F., and Huang, J. D. 1996. Inhibition of the intestinal digoxin absorption and exsorption by quinidine. Drug. Metab. Dispos. 24:142-147.
20. Sun, J., Hei, Z. G., Cheng, G., Wang, S. J., Hao, X. H., and Zou, M. J. 2004. Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction. Med. Sci. Monit. 10:RA5-RA14.
21. Tuncok, Y., Guven, H., Gelal, A., Apaydin, S., Gidener, S., and Fowler, J. 1995. Poisonings reported to the DPIC in Izmir, Turkey. Toxicol. Lett. 78:80.
22. Wang, Y. H., Chao, P. D., Hsiu, S. L., Wen, K. C., and Hou, Y. C. 2004. Lethal quercetin-digoxin interaction in pigs. Life. Sci. 74:1191-1197.