메뉴 건너뛰기




Volumn 39, Issue 7, 2007, Pages 482-494

Metabolic syndrome: Clinical concept and molecular basis

Author keywords

Adipocytokines; Adiponectin; Aquaporin 7; Metabolic syndrome; Visceral fat

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ANGIOTENSIN RECEPTOR ANTAGONIST; FATTY ACID; GLYCEROL; LIPOPROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 35648952206     PISSN: 07853890     EISSN: 16512219     Source Type: Journal    
DOI: 10.1080/07853890701491026     Document Type: Review
Times cited : (62)

References (68)
  • 2
    • 0020513545 scopus 로고
    • A novel technique for the determination of body fat by computed tomography
    • Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S. A novel technique for the determination of body fat by computed tomography. Int J Obes. 1983;7:437-45.
    • (1983) Int J Obes , vol.7 , pp. 437-445
    • Tokunaga, K.1    Matsuzawa, Y.2    Ishikawa, K.3    Tarui, S.4
  • 3
    • 0023117178 scopus 로고
    • Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity
    • Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intraabdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism. 1987;36:54-9.
    • (1987) Metabolism , vol.36 , pp. 54-59
    • Fujioka, S.1    Matsuzawa, Y.2    Tokunaga, K.3    Tarui, S.4
  • 4
    • 0025185678 scopus 로고
    • Close correlation of intra-abdominal fat accumulation to hypertension in obese women
    • Kanai H, Matsuzawa Y, Kotani K, Keno Y, Kobatake T, Nagai Y, et al. Close correlation of intra-abdominal fat accumulation to hypertension in obese women. Hypertension. 1990;16:484-90.
    • (1990) Hypertension , vol.16 , pp. 484-490
    • Kanai, H.1    Matsuzawa, Y.2    Kotani, K.3    Keno, Y.4    Kobatake, T.5    Nagai, Y.6
  • 6
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 7
    • 0024391834 scopus 로고
    • The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension
    • Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989;149:1514-20.
    • (1989) Arch Intern Med , vol.149 , pp. 1514-1520
    • Kaplan, N.M.1
  • 8
    • 0026021161 scopus 로고
    • Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173-94.
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • DeFronzo, R.A.1    Ferrannini, E.2
  • 9
    • 0001217241 scopus 로고
    • La differentiation sexuelle facteur determinant des formes de l'obesite
    • Vague J. La differentiation sexuelle facteur determinant des formes de l'obesite. Presse Med. 1947;30:339-40.
    • (1947) Presse Med , vol.30 , pp. 339-340
    • Vague, J.1
  • 11
    • 0021152686 scopus 로고
    • Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913
    • Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. Br Med J Clin Res Ed. 1984;288:1401-04.
    • (1984) Br Med J Clin Res Ed , vol.288 , pp. 1401-1404
    • Larsson, B.1    Svardsudd, K.2    Welin, L.3    Wilhelmsen, L.4    Bjorntorp, P.5    Tibblin, G.6
  • 12
    • 0028363169 scopus 로고
    • Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men
    • Nakamura T, Tokunaga K, Shimomura I, Nishida M, Yoshida S, Kotani K, et al. Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis. 1994;107:239-46.
    • (1994) Atherosclerosis , vol.107 , pp. 239-246
    • Nakamura, T.1    Tokunaga, K.2    Shimomura, I.3    Nishida, M.4    Yoshida, S.5    Kotani, K.6
  • 13
    • 33745784213 scopus 로고    scopus 로고
    • Koutsari C, Jensen MD. Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity. J Lipid Res. 2006;47:1643-50.
    • Koutsari C, Jensen MD. Thematic review series: patient-oriented research. Free fatty acid metabolism in human obesity. J Lipid Res. 2006;47:1643-50.
  • 14
    • 17344373417 scopus 로고    scopus 로고
    • Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation
    • Kuriyama H, Yamashita S, Shimomura I, Funahashi T, Ishigami M, Aragane K, et al. Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation. Hepatology. 1998;27:557-62.
    • (1998) Hepatology , vol.27 , pp. 557-562
    • Kuriyama, H.1    Yamashita, S.2    Shimomura, I.3    Funahashi, T.4    Ishigami, M.5    Aragane, K.6
  • 15
    • 0026683325 scopus 로고
    • Oleate-mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation
    • White AL, Graham DL, LeGros J, Pease RJ, Scott J. Oleate-mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation. J Biol Chem. 1992;267:15657-64.
    • (1992) J Biol Chem , vol.267 , pp. 15657-15664
    • White, A.L.1    Graham, D.L.2    LeGros, J.3    Pease, R.J.4    Scott, J.5
  • 18
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
    • Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 1998;12:3182-94.
    • (1998) Genes Dev , vol.12 , pp. 3182-3194
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3    Ikemoto, S.4    Bashmakov, Y.5    Goldstein, J.L.6
  • 20
    • 15844381594 scopus 로고    scopus 로고
    • Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity
    • Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med. 1996;2:800-03.
    • (1996) Nat Med , vol.2 , pp. 800-803
    • Shimomura, I.1    Funahashi, T.2    Takahashi, M.3    Maeda, K.4    Kotani, K.5    Nakamura, T.6
  • 22
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 24
    • 0029980285 scopus 로고    scopus 로고
    • cDNA cloning and expression of a novel adipose specific collagen-like factor, apMa (Adipose Most Abundant gene transcript 1)
    • Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apMa (Adipose Most Abundant gene transcript 1). Biochem Biophys Res Commun. 1996;221:286-9.
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 286-289
    • Maeda, K.1    Okubo, K.2    Shimomura, I.3    Funahashi, T.4    Matsuzawa, Y.5    Matsubara, K.6
  • 27
  • 28
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein, adiponectin
    • Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein, adiponectin. Circulation. 1999;100:2473-6.
    • (1999) Circulation , vol.100 , pp. 2473-2476
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3    Maeda, K.4    Kuriyama, H.5    Okamoto, Y.6
  • 29
    • 0034641647 scopus 로고    scopus 로고
    • Adiponectin, adipocyte-derived plasma protein, inhibits endothelial NF-kB signaling through cAMP-dependent pathway
    • Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al. Adiponectin, adipocyte-derived plasma protein, inhibits endothelial NF-kB signaling through cAMP-dependent pathway. Circulation. 2000;102:1296-301.
    • (2000) Circulation , vol.102 , pp. 1296-1301
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3    Okamoto, Y.4    Maeda, K.5    Kuriyama, H.6
  • 30
    • 0037129861 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein, adiponectin, acts as a platelets growth factor-BB-binding protein and regulates growth factor-induced common post-receptor signal in vascular smooth muscle cell
    • Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, et al. Adipocyte-derived plasma protein, adiponectin, acts as a platelets growth factor-BB-binding protein and regulates growth factor-induced common post-receptor signal in vascular smooth muscle cell. Circulation. 2002;105:2893-8.
    • (2002) Circulation , vol.105 , pp. 2893-2898
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3    Maeda, K.4    Kuriyama, H.5    Okamoto, Y.6
  • 31
    • 0035957040 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    • Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation. 2001;103:1057-63.
    • (2001) Circulation , vol.103 , pp. 1057-1063
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3    Nishida, M.4    Matsuyama, A.5    Okamoto, Y.6
  • 32
    • 0034284038 scopus 로고    scopus 로고
    • Adiponectin, a novel member of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    • Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, et al. Adiponectin, a novel member of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood. 2000;96:1723-32.
    • (2000) Blood , vol.96 , pp. 1723-1732
    • Yokota, T.1    Oritani, K.2    Takahashi, I.3    Ishikawa, J.4    Matsuyama, A.5    Ouchi, N.6
  • 33
    • 2442464884 scopus 로고    scopus 로고
    • Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages
    • Kumada M, Kihara S, Ouchi N, Kobayashi H, Okamoto Y, Ohashi K, et al. Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation. 2004;109:2046-9.
    • (2004) Circulation , vol.109 , pp. 2046-2049
    • Kumada, M.1    Kihara, S.2    Ouchi, N.3    Kobayashi, H.4    Okamoto, Y.5    Ohashi, K.6
  • 34
    • 0037180472 scopus 로고    scopus 로고
    • Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice
    • Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2002;106:2767-70.
    • (2002) Circulation , vol.106 , pp. 2767-2770
    • Okamoto, Y.1    Kihara, S.2    Ouchi, N.3    Nishida, M.4    Arita, Y.5    Kumada, M.6
  • 35
    • 0037020170 scopus 로고    scopus 로고
    • Role of adiponectin in preventing vascular stenosis - the missing link of adipo-vascular axis
    • Matsuda M, Shimomura I, Sata M, Arita Y, Nishida M, Maeda N, et al. Role of adiponectin in preventing vascular stenosis - the missing link of adipo-vascular axis. J Biol Chem. 2002;277:37487-91.
    • (2002) J Biol Chem , vol.277 , pp. 37487-37491
    • Matsuda, M.1    Shimomura, I.2    Sata, M.3    Arita, Y.4    Nishida, M.5    Maeda, N.6
  • 36
    • 27144457438 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    • Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med. 2005;11:1096-103.
    • (2005) Nat Med , vol.11 , pp. 1096-1103
    • Shibata, R.1    Sato, K.2    Pimentel, D.R.3    Takemura, Y.4    Kihara, S.5    Ohashi, K.6
  • 37
    • 0037432152 scopus 로고    scopus 로고
    • Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    • Ouchi N, Kihara S, Funahashi T, Nakamura T, Nishida M, Kumada M, et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation. 2003;107:671-4.
    • (2003) Circulation , vol.107 , pp. 671-674
    • Ouchi, N.1    Kihara, S.2    Funahashi, T.3    Nakamura, T.4    Nishida, M.5    Kumada, M.6
  • 39
    • 0036139677 scopus 로고    scopus 로고
    • Adiponectin, the most abundant adipocyte-derived protein, is functionally related to metabolic risk factors and predicts cardiovascular outcomes in end stage renal disease
    • Zoccali C, Mallamaci F, Tripepi G, Cutrupi S, Parlongo S, Malatino L, et al. Adiponectin, the most abundant adipocyte-derived protein, is functionally related to metabolic risk factors and predicts cardiovascular outcomes in end stage renal disease. J Am Soc Nephrol. 2002;13:134-41.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 134-141
    • Zoccali, C.1    Mallamaci, F.2    Tripepi, G.3    Cutrupi, S.4    Parlongo, S.5    Malatino, L.6
  • 42
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Evidence for a role of insulin resistance and/or hyperinsulinemia
    • Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes: Evidence for a role of insulin resistance and/or hyperinsulinemia. J Clin Endocrinol Metab. 2001;86:1930-5.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3    Hotta, K.4    Matsuzawa, Y.5    Pratley, R.E.6
  • 43
    • 0035039227 scopus 로고    scopus 로고
    • Circulating concentrations of the adipocyte protein, adiponectin, are decreased in parallel with reduced insulin sensitivity during the progression to type-2 diabetes in rhesus monkeys
    • Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, et al. Circulating concentrations of the adipocyte protein, adiponectin, are decreased in parallel with reduced insulin sensitivity during the progression to type-2 diabetes in rhesus monkeys. Diabetes. 2001;50:1126-33.
    • (2001) Diabetes , vol.50 , pp. 1126-1133
    • Hotta, K.1    Funahashi, T.2    Bodkin, N.L.3    Ortmeyer, H.K.4    Arita, Y.5    Hansen, B.C.6
  • 45
    • 0037031088 scopus 로고    scopus 로고
    • Adiponectin protects against development of type 2 diabetes in the Pima Indian population
    • Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, et al. Adiponectin protects against development of type 2 diabetes in the Pima Indian population. Lancet. 2002;360:57-8.
    • (2002) Lancet , vol.360 , pp. 57-58
    • Lindsay, R.S.1    Funahashi, T.2    Hanson, R.L.3    Matsuzawa, Y.4    Tanaka, S.5    Tataranni, P.A.6
  • 46
    • 0036303146 scopus 로고    scopus 로고
    • Association of adiponectin/ACRP30/AdipoQ mutation with type 2 diabetes mellitus. A candidate gene for the insulin resistance syndrome
    • Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, et al. Association of adiponectin/ACRP30/AdipoQ mutation with type 2 diabetes mellitus. A candidate gene for the insulin resistance syndrome. Diabetes. 2002;51:2325-58.
    • (2002) Diabetes , vol.51 , pp. 2325-2358
    • Kondo, H.1    Shimomura, I.2    Matsukawa, Y.3    Kumada, M.4    Takahashi, M.5    Matsuda, M.6
  • 47
    • 11144356189 scopus 로고    scopus 로고
    • Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
    • Ohashi K, Ouchi N, Kihara S, Funahashi T, Nakamura T, Sumitsuji S, et al. Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease. J Am Coll Cardiol. 2004;43:1195-200.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1195-1200
    • Ohashi, K.1    Ouchi, N.2    Kihara, S.3    Funahashi, T.4    Nakamura, T.5    Sumitsuji, S.6
  • 48
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004;279:1304-09.
    • (2004) J Biol Chem , vol.279 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3    Kumada, M.4    Sato, K.5    Inoue, T.6
  • 49
    • 0242581695 scopus 로고    scopus 로고
    • Adiponectin stimulates production of nitric oxide in vascular endothelial cells
    • Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem. 2003;278:45021-6.
    • (2003) J Biol Chem , vol.278 , pp. 45021-45026
    • Chen, H.1    Montagnani, M.2    Funahashi, T.3    Shimomura, I.4    Quon, M.J.5
  • 51
    • 33744979305 scopus 로고    scopus 로고
    • Adiponectin replenishment ameliorates obesity-related hypertension
    • Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, et al. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension. 2006;47:1108-16.
    • (2006) Hypertension , vol.47 , pp. 1108-1116
    • Ohashi, K.1    Kihara, S.2    Ouchi, N.3    Kumada, M.4    Fujita, K.5    Hiuge, A.6
  • 52
    • 19944369735 scopus 로고    scopus 로고
    • Adiponectin-mediated modulation of hypertrophic signals in the heart
    • Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DR, et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med. 2004;10:1384-9.
    • (2004) Nat Med , vol.10 , pp. 1384-1389
    • Shibata, R.1    Ouchi, N.2    Ito, M.3    Kihara, S.4    Shiojima, I.5    Pimentel, D.R.6
  • 58
    • 34548249277 scopus 로고    scopus 로고
    • Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model
    • Apr 9 [Epub ahead of print
    • Kamada Y, Matsumoto H, Tamura S, Fukushima J, Kiso S, Fukui K, et al., Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. J Hepatol. 2007 Apr 9 [Epub ahead of print].
    • (2007) J Hepatol
    • Kamada, Y.1    Matsumoto, H.2    Tamura, S.3    Fukushima, J.4    Kiso, S.5    Fukui, K.6
  • 59
    • 27844463517 scopus 로고    scopus 로고
    • Rimonabant in Obesity-Lipids Study Group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Despres JP, Golay A, Sjostrom L; Rimonabant in Obesity-Lipids Study Group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med. 2005;353:2121-34.
    • (2005) N Engl J Med , vol.353 , pp. 2121-2134
    • Despres, J.P.1    Golay, A.2    Sjostrom, L.3
  • 60
    • 0035462629 scopus 로고    scopus 로고
    • PPARg ligands increase expression and plasma concentration of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, et al. PPARg ligands increase expression and plasma concentration of adiponectin, an adipose-derived protein. Diabetes. 2001;50:2094-9.
    • (2001) Diabetes , vol.50 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3    Kihara, S.4    Nishizawa, H.5    Kishida, K.6
  • 61
    • 0037677767 scopus 로고    scopus 로고
    • Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    • Iwaki M, Matsuda M, Maeda N, Funahashi T, Matsuzawa Y, Makishima M, et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes. 2003;52:1655-63.
    • (2003) Diabetes , vol.52 , pp. 1655-1663
    • Iwaki, M.1    Matsuda, M.2    Maeda, N.3    Funahashi, T.4    Matsuzawa, Y.5    Makishima, M.6
  • 64
    • 33750604403 scopus 로고    scopus 로고
    • Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation
    • Kurata A, Nishizawa H, Kihara S, Maeda N, Sonoda M, Okada T, et al. Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation. Kidney Int. 2006;70:1717-24.
    • (2006) Kidney Int , vol.70 , pp. 1717-1724
    • Kurata, A.1    Nishizawa, H.2    Kihara, S.3    Maeda, N.4    Sonoda, M.5    Okada, T.6
  • 66
    • 0041434905 scopus 로고    scopus 로고
    • Reducing Risks, Promoting Health Life
    • Geneva: World Health Organization
    • Reducing Risks, Promoting Health Life. The World Health Report. Geneva: World Health Organization, 2002.
    • (2002) The World Health Report
  • 68
    • 0035174420 scopus 로고    scopus 로고
    • Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees. A case-control study
    • Nakamura T, Tsubono Y, Kameda-Takemura K, Funahashi T, Yamashita S, Hisamichi S, et al. Magnitude of sustained multiple risk factors for ischemic heart disease in Japanese employees. A case-control study. Circ J. 2001;65:11-17.
    • (2001) Circ J , vol.65 , pp. 11-17
    • Nakamura, T.1    Tsubono, Y.2    Kameda-Takemura, K.3    Funahashi, T.4    Yamashita, S.5    Hisamichi, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.