Two Gr Genes Underlie Sugar Reception in Drosophila

Neuron

Volumn 56, Issue 3, 2007, Pages 503-516

  Dahanukar, Anupama ^a   Lei, Ya Ting ^a   Kwon, Jae Young ^a   Carlson, John R ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

CELLBIO; MOLNEURO

Indexed keywords

ALPHA GLUCOSIDASE; FRUCTOSE; GLUCOSE; LEUCROSE; MALTITOL; MALTOSE; MALTOTRIOSE; PALATINOSE; RAFFINOSE; SUCROSE; TREHALOSE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DROSOPHILA; GENE; GENE EXPRESSION; GENETIC ANALYSIS; GR5A GENE; GR64A GENE; IN SITU HYBRIDIZATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTIVE FIELD; SENSORY NERVE CELL; TASTE BUD;

AFFERENT PATHWAYS; ANIMALS; BRAIN; CARBOHYDRATES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEEDING BEHAVIOR; GANGLIA, INVERTEBRATE; GENE EXPRESSION; MUTATION; NERVOUS SYSTEM; NEURONS, AFFERENT; RECEPTORS, CELL SURFACE; TASTE;

EID: 35648936454     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2007.10.024     Document Type: Article

References (44)

1. Benton R., Sachse S., Michnick S.W., and Vosshall L.B. Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. PLoS Biol. 4 (2006) e20
2. Brand A.H., and Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118 (1993) 401-415
3. Cheng, E., Chang, C.-M., and Sun, H. Y. (1992). An improved proboscis extension assay. Drosophila Information Newsletter 6.
4. Chyb S., Dahanukar A., Wickens A., and Carlson J.R. Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proc. Natl. Acad. Sci. USA 100 (2003) 14526-14530
5. Clyne P.J., Warr C.G., Freeman M.R., Lessing D., Kim J., and Carlson J.R. A novel family of divergent seven-transmembrane proteins: Candidate odorant receptors in Drosophila. Neuron 22 (1999) 327-338
6. Clyne P.J., Warr C.G., and Carlson J.R. Candidate taste receptors in Drosophila. Science 287 (2000) 1830-1834
7. Dahanukar A., Foster K., van der Goes van Naters W.M., and Carlson J.R. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nat. Neurosci. 4 (2001) 1182-1186
8. Dethier V.G. The Hungry Fly (1976), Harvard University Press, Cambridge, MA
9. Dunipace L., Meister S., McNealy C., and Amrein H. Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system. Curr. Biol. 11 (2001) 822-835
10. Edgecomb R.S., and Murdock L.L. Central projections of axons from taste hairs on the labellum and tarsi of the blowfly, Phormia regina Meigen. J. Comp. Neurol. 315 (1992) 431-444
11. Falk R., Bleiser-Avivi N., and Atidia J. Labellar taste organs of Drosophila melanogaster. J. Morphol. 150 (1976) 327-342
12. Fujishiro N., Kijima H., and Morita H. Impulse frequency and action potential amplitude in labellar chemosensory neurons of Drosophila melanogaster. J. Insect Physiol. 30 (1984) 317-325
13. Furuyama A., Koganezawa M., and Shimada I. Multiple receptor sites for nucleotide reception in the labellar taste receptor cells of the fleshfly Boettcherisca peregrina. J. Insect Physiol. 45 (1999) 249-255
14. Goldman A.L., van der Goes van Naters W., Lessing D., Warr C.G., and Carlson J.R. Coexpression of two functional odor receptors in one neuron. Neuron 45 (2005) 661-666
15. Hiroi M., Marion-Poll F., and Tanimura T. Differentiated response to sugars among labellar chemosensilla in Drosophila. Zoolog. Sci. 19 (2002) 1009-1018
16. Jiao Y., Moon S.J., and Montell C. A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose, identified by mRNA tagging. Proc. Natl. Acad. Sci. USA 104 (2007) 14110-14115
17. Kim N.C., and Kinghorn A.D. Highly sweet compounds of plant origin. Arch. Pharm. Res. 25 (2002) 725-746
18. Marella S., Fischler W., Kong P., Asgarian S., Rueckert E., and Scott K. Imaging taste responses in the fly brain reveals a functional map of taste category and behavior. Neuron 49 (2006) 285-295
19. Meunier N., Marion-Poll F., Rospars J.P., and Tanimura T. Peripheral coding of bitter taste in Drosophila. J. Neurobiol. 56 (2003) 139-152
20. Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., et al. Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. Genome Biol. 3 (2002) research0083.1-0083.22
21. Moon S.J., Kottgen M., Jiao Y., Xu H., and Montell C. A taste receptor required for the caffeine response in vivo. Curr. Biol. 16 (2006) 1812-1817
22. Nayak S.V., and Singh R.N. Sensilla on the tarsal segments and mouthparts of adult Drosophila melanogaster Meigen (Diptera: Drosophilidae). Int. J. Insect Morphol. Embryol. 12 (1983) 273-291
23. Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J., and Zuker C.S. Mammalian sweet taste receptors. Cell 106 (2001) 381-390
24. Nelson G., Chandrashekar J., Hoon M.A., Feng L., Zhao G., Ryba N.J., and Zuker C.S. An amino-acid taste receptor. Nature 416 (2002) 199-202
25. Neuhaus E.M., Gisselmann G., Zhang W., Dooley R., Störtkuhl K., and Hatt H. Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster. Nat. Neurosci. 8 (2005) 15-17
26. Python F., and Stocker R.F. Adult-like complexity of the larval antennal lobe of D. melanogaster despite markedly low numbers of odorant receptor neurons. J. Comp. Neurol. 445 (2002) 374-387
27. Ray K., Hartenstein V., and Rodrigues V. Development of the taste bristles on the labellum of Drosophila melanogaster. Dev. Biol. 155 (1993) 26-37
28. Robertson H.M., Warr C.G., and Carlson J.R. Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 100 (2003) 14537-14542
29. Rodrigues V., and Siddiqi O. Genetic-analysis of chemosensory pathway. Proc. Indian Acad. Sci. Sect. B Biol. Sci. 87 (1978) 147-160
30. Scott K., Brady Jr. R., Cravchik A., Morozov P., Rzhetsky A., Zuker C., and Axel R. A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell 104 (2001) 661-673
31. Shanbhag S., and Singh R.N. Functional implications of the projections of neurons from individual labellar sensillum of Drosophila melanogaster as revealed by neuronal marker horseradish peroxidase. Cell Tissue Res. 267 (1992) 273-282
32. Shanbhag S.R., Park S.K., Pikielny C.W., and Steinbrecht R.A. Gustatory organs of Drosophila melanogaster: fine structure and expression of the putative odorant-binding protein PBPRP2. Cell Tissue Res. 304 (2001) 423-437
33. Shiraiwa, T., and Carlson, J.R. (2007). Proboscis extension response (PER) assay in Drosophila. Journal of Visualized Experiments 3. ==http://www.jove.com/Details.htm?ID=193&VID=155.
34. Slone J., Daniels J., and Amrein H. Sugar receptors in Drosophila. Curr. Biol. 17 (2007) 1-8
35. Stocker R.F. The organization of the chemosensory system in Drosophila melanogaster: a review. Cell Tissue Res. 275 (1994) 3-26
36. Stocker R.F., and Schorderet M. Cobalt filling of sensory projections from internal and external mouthparts in Drosophila. Cell Tissue Res. 216 (1981) 513-523
37. Tanimura T., and Shimada I. Multiple receptor proteins for sweet taste in Drosophila discriminated by papain treatment. J. Comp. Physiol. 141 (1981) 265-269
38. Thorne N., Chromey C., Bray S., and Amrein H. Taste perception and coding in Drosophila. Curr. Biol. 14 (2004) 1065-1079
39. U.S. Department of Agriculture, Agricultural Research Service (2006). USDA National Nutrient Database for Standard Reference, Release 19. http://www.ars.usda.gov/ba/bhnrc/ndl.
40. Ueno K., Ohta M., Morita H., Mikuni Y., Nakajima S., Yamamoto K., and Isono K. Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr. Biol. 11 (2001) 1451-1455
41. Van der Goes van Naters W., and Carlson J.R. Insects as chemosensors of humans and crops. Nature 444 (2006) 302-307
42. Vosshall L.B., and Stocker R.F. Molecular architecture of smell and taste in Drosophila. Annu. Rev. Neurosci. 30 (2007) 505-533
43. Wang Z., Singhvi A., Kong P., and Scott K. Taste representations in the Drosophila brain. Cell 117 (2004) 981-991
44. Wieczorek H., and Wolff G. The labellar sugar receptor of Drosophila. J. Comp. Physiol. [A] 164 (1989) 825-834