cAMP and purinergic P(2y) receptors upregulate and enhance inducible NO synthase mRNA and protein in vive

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 273, Issue 5 17-5, 1997, Pages

  Greenberg, Stan S ^a,b   Zhao, Xinfang ^a   Wang, Ji Fang ^a   Hua, Li ^a   Ouyang, Jie ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine 3',5' cyclic monophosphate; Diethyldithiocarbamate; Lipopolysaccharide; Nitric oxide; Transcription factors; Tumor necrosis factor

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; BACTERIUM LIPOPOLYSACCHARIDE; BUCLADESINE; CYCLIC AMP; CYTOKINE; DIETHYLTHIOCARBAMATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PURINE P2Y RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; 2-METHYLTHIO-ATP; ADENOSINE TRIPHOSPHATE; DIETHYLDITHIOCARBAMIC ACID; DRUG DERIVATIVE; ISOPRENALINE; LIPOPOLYSACCHARIDE; NUCLEOTIDE; PURINE P2 RECEPTOR; SALBUTAMOL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENETIC TRANSCRIPTION; IMMUNOLOGY; LUNG; LUNG LAVAGE; METABOLISM; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ALBUTEROL; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; BUCLADESINE; CHEMOTAXIS, LEUKOCYTE; CYCLIC AMP; DITIOCARB; ENZYME INDUCTION; ISOPROTERENOL; LIPOPOLYSACCHARIDES; LUNG; MACROPHAGES, ALVEOLAR; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; THIONUCLEOTIDES; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031278795     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1997.273.5.l967     Document Type: Article

References (11)

1. Akerblom, I. E., E. P. Slater, M. Beato, J. D. Baxter, and P. L. Mellon. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer. Science 241: 350-353, 1988.
2. Andersen, H. U., D. Mauricio, A. E. Karlsen, T. Mandrup-Poulsen, J. H. Nielsen, and J. Nerup. Interleukin-1β-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine. Eur. J. Endocrinol. 134: 251-259, 1996.
3. Ayoubi, T. A. Y., and W. J. M. Van De Ven. Regulation of gene expression by alternative promoters. FASEB J. 10: 453-460, 1996.
4. Barratt, G. M., K. Raddassi, J. F. Petit, and J. P. Tenu. MDP and LPS act synergistically to induce arginine-dependent cytostatic activity in rat alveolar macrophages. Int. J. Immunopharmacol. 13: 159-165, 1991.
5. Bourre, J. M., A. Faivre, O. Dumont, A. Nouvelot, C. Loudes, J. Puymirat, and A. Tixier-Vidal. Effect of polyunsaturated fatty acids on fetal mouse brain cells in culture in a chemically defined medium. J. Neurochem. 41: 1234-1242, 1983.
6. Brune, B., S. Dimmeler, Y. Molina, L. Vedia, and E. G. Lapetina. Nitric oxide: a signal for ADP-ribosylation of proteins. Life Sci. 54: 61-70, 1994.
7. Brune, B., and E. G. Lapetina. Phosphorylation of nitric oxide synthase by protein kinase A. Biochem. Biophys. Res. Commun. 181: 921-926, 1991.
8. Bulut, V., A. Severn, and F. Y. Liew. Nitric oxide production by murine macrophages is inhibited by prolonged elevation of cyclic AMP. Biochem. Biophys. Res. Commun. 195: 1134-1138, 1993.
9. Cho, H. J., E. Martin, Q. W. Xie, S. Sassa, and C. Nathan. Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin. Proc. Natl. Acad. Sci. USA 92: 11514-11518, 1995.
10. Colasanti, M., T. Persichini, M. Menegazzi, S. Mariotto, E. Giordano, C. M. Caldarera, V. Sogos, G. M. Lauro, and H. Suzuki. Induction of nitric oxide synthase mRNA expression. Suppression by exogenous nitric oxide. J. Biol. Chem. 270: 26731-26733, 1995.
11. De Belder, A., M. Radomski, V. Hancock, A. Brown, S. Moncada, and J. Martin. Megakaryocytes from patients with coronary atherosclerosis express the inducible nitric oxide synthase. Arterscler. Throm. Vasc. Biol. 15: 637-641, 1995.