Mitogenic component in polar lipid-enriched Anaplasma phagocytophilum membranes

Clinical and Vaccine Immunology

Volumn 14, Issue 10, 2007, Pages 1260-1265

  Choi, Kyoung Seong ^a,b   Dumler, J Stephen ^b  

^a Kyungpook National University   (South Korea)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOLIPID; LIPOPROTEIN; TOLL LIKE RECEPTOR 2;

ANAPLASMA PHAGOCYTOPHILUM; ANIMAL CELL; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MITOGENESIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SPLEEN CELL; VIRULENCE;

ANAPLASMA PHAGOCYTOPHILUM; ANIMALS; CELL MEMBRANE; CELL PROLIFERATION; HL-60 CELLS; HUMANS; IMMUNITY, NATURAL; MEMBRANE LIPIDS; MICE; MICE, INBRED C57BL; MITOGENS; SPLEEN; VIRULENCE;

EID: 35548949849     PISSN: 15566811     EISSN: None     Source Type: Journal    
DOI: 10.1128/CVI.00204-07     Document Type: Article

References (30)

1. Akkoyunlu, M., S. E. Malawista, J. Anguita, and E. Fikrig. 2001. Exploitation of interleukin-8-induced neutrophil Chemotaxis by the agent of human granulocytic ehrlichiosis. Infect. Immun. 69:5577-5588.
2. + T-lymphocyte and immunoglobulin G2 responses in calves immunized with Anaplasma marginale outer membranes and protected against homologous challenge. Infect. Immun. 66:5406-5413.
3. Browning, M. D., J. W. Garyu, J. S. Dumler, and D. G. Scorpio. 2006. Role of reactive nitrogen species in development of hepatic injury in a C57bl/6 mouse model of human granulocytic anaplasmosis. Comp. Med. 56:55-62.
4. Bunnell, J. E., E. R. Trigiani, S. R. Srinivas, and J. S. Dumler. 1999. Development and distribution of pathologic lesions are related to immune status and tissue deposition of human granulocytic ehrlichiosis agent-infected cells in a murine model system. J. Infect. Dis. 180:546-550.
5. Choi, K. S., J. Garyu, J. Park, and J. S. Dumler. 2003. Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin. Infect. Immun. 71:4586-4594.
6. Choi, K. S., D. J. Grab, and J. S. Dumler. 2004. Anaplasma phagocytophilum infection induces protracted neutrophil degranulation. Infect. Immun. 72: 3680-3683.
7. Choi, K. S., D. G. Scorpio, N. C. Barat, and J. S. Dumler. 2007. Msp2 variation in Anaplasma phagocytophilum in vivo does not stimulate T cell immune responses or interferon-gamma production. FEMS Immunol. Med. Microbiol. 49:374-386. [Epub ahead of print.]
8. Choi, K. S., D. G. Scorpio, and J. S. Dumler. 2004. Anaplasma phagocytophilum ligation to Toll-like receptor (TLR) 2, but not to TLR4, activates macrophages for nuclear factor-kappa B nuclear translocation. J. Infect. Dis. 189:1921-1925.
9. Choi, K.-S., T. Webb, M. Oelke, D. G. Scorpio, and J. S. Dumler. 2007. Differential innate immune cell activation and proinflammatory response in Anaplasma phagocytophilum infection. Infect. Immun. 75:3124-3130.
10. Dumler, J. S., K. S. Choi, J. C. Garcia-Garcia, N. S. Barat, D. G. Scorpio, J. W. Garyu, D. J. Grab, and J. S. Bakken. 2005. Human granulocytic anaplasmosis and Anaplasma phagocytophilum. Emerg. Infect. Dis. 11:1828-1834.
11. Fischer, K., E. Scotet, M. Niemeyer, H. Koebernick, J. Zerrahn, S. Maillet, R. Hurwitz, M. Kursar, M. Bonneville, S. H. Kaufmann, and U. E. Schaible. 2004. Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc. Natl. Acad. Sci. USA 101:10685-10690.
12. Guinet, F., C. Ronet, M. Mempel, M. Huerre, E. Carniel, and G. Gachelin. 2002. NKT cells-containing inflammatory lesions induced by Yersinia pseudotuberculosis glycolipids. Immunol. Lett. 80:113-118.
13. Hodzic, E., J. W. Ijdo, S. Feng, P. Katavolos, W. Sun, C. H. Maretzki, D. Fish, E. Fikrig, S. R. Telford III, and S. W. Barthold. 1998. Granulocytic ehrlichiosis in the laboratory mouse. J. Infect. Dis. 177:737-745.
14. Kinjo, Y., E. Tupin, D. Wu, M. Fujio, R. Garcia-Navarro, M. R. Benhnia, D. M. Zajonc, G. Ben-Menachem, G. D. Ainge, G. F. Painter, A. Khurana, K. Hoebe, S. M. Behar, B. Beutler, I. A. Wilson, M. Tsuji, T. J. Sellati, C. H. Wong, and M. Kronenberg. 2006. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol. 7:978-986.
15. Lepidi, H., J. E. Bunnell, M. E. Martin, J. E. Madigan, S. Stuen, and J. S. Dumler. 2000. Comparative pathology, and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections. Am. J. Trop. Med. Hyg. 62:29-37.
16. Lin, M., and Y. Rikihisa. 2003. Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infect. Immun. 71:5324-5331.
17. Martin, M. E., J. E. Bunnell, and J. S. Dumler. 2000. Pathology, immunohistology, and cytokine responses in early phases of human granulocytic ehrlichiosis in a murine model. J. Infect. Dis. 181:374-378.
18. Martin, M. E., K. Caspersen, and J. S. Dumler. 2001. Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am. J. Pathol. 158: 1881-1888.
19. Mattner, J., K. L. Debord, N. Ismail, R. D. Goff, C. Cantu III, D. Zhou, P. Saint-Mezard, V. Wang, Y. Gao, N. Yin, K. Hoebe, O. Schneewind, D. Walker, B. Beutler, L. Teyton, P. B. Savage, and A. Bendelac. 2005. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525-529.
20. Paparone, P. W., P. Ljubich, G. A. Rosman, and N. T. Nazha. 1995. Ehrlichiosis with pancytopenia and ARDS. N. J. Med. 92:381-385.
21. Pusterla, N., J. E. Madigan, K. M. Asanovich, J. S. Chae, E. Derock, C. M. Leutenegger, J. B. Pusterla, H. Lutz, and J. S. Dumler. 2000. Experimental inoculation with human granulocytic Ehrlichia agent derived from high- and low-passage cell culture in horses. J. Clin. Microbiol. 38:1276-1278.
22. Remy, V., Y. Hansmann, S. De Martino, D. Christmann, and P. Brouqui. 2003. Human anaplasmosis presenting as atypical pneumonitis in France. Clin. Infect. Dis. 37:846-848.
23. Reubel, G. H., R. B. Kimsey, J. E. Barlough, and J. E. Madigan. 1998. Experimental transmission of Ehrlichia equi to horses through naturally infected ticks (Ixodes pacificus) from Northern California. J. Clin. Microbiol. 36:2131-2134.
24. Schnaar, R. L. 1994. Isolation of glycosphingolipids. Methods Enzymol. 230:348-370.
25. Scorpio, D. G., M. Akkoyunlu, E. Fikrig, and J. S. Dumler. 2004. CXCR2 blockade influences Anaplasma phagocytophilum propagation but not histopathology in the mouse model of human granulocytic anaplasmosis. Clin. Diagn. Lab. Immunol. 11:963-968.
26. Scorpio, D. G., F. D. von Loewenich, C. Bogdan, and J. S. Dumler. 2005. Innate immune tissue injury and murine HGA: tissue injury in the murine model of granulocytic anaplasmosis relates to host innate immune response and not pathogen load. Ann. N. Y. Acad. Sci. 1063:425-428.
27. Scorpio, D. G., F. D. von Loewenich, H. Gobel, C. Bogdan, and J. S. Dumler. 2006. Innate immune response to Anaplasma phagocytophilum contributes to hepatic injury. Clin. Vaccine Immunol. 13:806-809.
28. von Loewenich, F. D., D. G. Scorpio, U. Reischl, J. S. Dumler, and C. Bogdan. 2004. Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88. Eur. J. Immunol. 34:1789-1797.
29. Wemme, H., S. Pfeifer, R. Heck, and J. Muller-Quernheim. 1992. Measurement of lymphocyte proliferation: critical analysis of radioactive and photometric methods. Immunobiology 185:78-89.
30. Wong, S., and L. J. Grady. 1996. Ehrlichia infection as a cause of severe respiratory distress. N. Engl. J. Med. 334:273.