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Volumn 9, Issue 21, 2007, Pages 4319-4322

A nonacid degradable linker for solid-phase synthesis

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BIPHENYL DERIVATIVE; PEPTIDE; POLYSTYRENE DERIVATIVE; UNCLASSIFIED DRUG; WANG RESIN;

EID: 35548933801     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol701879s     Document Type: Article
Times cited : (10)

References (27)
  • 1
    • 0003767945 scopus 로고    scopus 로고
    • Albericio, F, Kates, S. A, Eds, Marcel Decker: New York
    • (a) Solid Phase Synthesis: A practical guide; Albericio, F., Kates, S. A., Eds.; Marcel Decker: New York, 2000.
    • (2000) Solid Phase Synthesis: A practical guide
  • 2
    • 0004127585 scopus 로고    scopus 로고
    • Nicolau, K. C, Hanko, R, Hatwig, W, Eds, Wiley-VCH: Winheim
    • (b) Handbook of Combinatorial Chemistry; Nicolau, K. C.; Hanko, R.; Hatwig, W., Eds.; Wiley-VCH: Winheim, 2002.
    • (2002) Handbook of Combinatorial Chemistry
  • 3
    • 35548933700 scopus 로고    scopus 로고
    • Linkers, as defined by Bradley et al, see ref 4d, can be considered simply as immobilized protecting groups and will be classified into one of two types: (i) Integral linkers in which part of the solid support core forms part or all of the linker and (ii) nonintegral (or grafted) linkers in which the linker is attached to the resin core. A linker which has been prepared in solution will be defined as a unloaded linker
    • Linkers, as defined by Bradley et al. (see ref 4d), can be considered simply as immobilized protecting groups and will be classified into one of two types: (i) Integral linkers in which part of the solid support core forms part or all of the linker and (ii) nonintegral (or grafted) linkers in which the linker is attached to the resin core. A linker which has been prepared in solution will be defined as a unloaded linker.
  • 18
    • 35549012787 scopus 로고    scopus 로고
    • For instance, Gu and Silverman (see ref 3b) designed a backbone linker stable to reflux TFA
    • For instance, Gu and Silverman (see ref 3b) designed a backbone linker stable to reflux TFA.
  • 23
    • 35548990092 scopus 로고    scopus 로고
    • Gu and Silverman (ref 3b) incorporated the precursor of their backbone linker to the resin through a metal-catalyzed coupling reaction.
    • Gu and Silverman (ref 3b) incorporated the precursor of their backbone linker to the resin through a metal-catalyzed coupling reaction.
  • 24
    • 35549011401 scopus 로고    scopus 로고
    • Phenylmethylethers are rather stable to acid conditions, and even in the case of cleavage, the methyl cation formed is less reactive in comparison with benzyl cations
    • Phenylmethylethers are rather stable to acid conditions, and even in the case of cleavage, the methyl cation formed is less reactive in comparison with benzyl cations.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.