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Linkers, as defined by Bradley et al, see ref 4d, can be considered simply as immobilized protecting groups and will be classified into one of two types: (i) Integral linkers in which part of the solid support core forms part or all of the linker and (ii) nonintegral (or grafted) linkers in which the linker is attached to the resin core. A linker which has been prepared in solution will be defined as a unloaded linker
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Linkers, as defined by Bradley et al. (see ref 4d), can be considered simply as immobilized protecting groups and will be classified into one of two types: (i) Integral linkers in which part of the solid support core forms part or all of the linker and (ii) nonintegral (or grafted) linkers in which the linker is attached to the resin core. A linker which has been prepared in solution will be defined as a unloaded linker.
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4
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(a) Fernandez, J.-C.; Sole-Feu, L.; Fernandez-Forner, D.; de la Figuera, N.; Forns, P.; Albericio, F. QSAR Comb. Sci. 2006, 25, 961-965.
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35549012787
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For instance, Gu and Silverman (see ref 3b) designed a backbone linker stable to reflux TFA
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For instance, Gu and Silverman (see ref 3b) designed a backbone linker stable to reflux TFA.
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19
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23
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35548990092
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Gu and Silverman (ref 3b) incorporated the precursor of their backbone linker to the resin through a metal-catalyzed coupling reaction.
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Gu and Silverman (ref 3b) incorporated the precursor of their backbone linker to the resin through a metal-catalyzed coupling reaction.
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24
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35549011401
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Phenylmethylethers are rather stable to acid conditions, and even in the case of cleavage, the methyl cation formed is less reactive in comparison with benzyl cations
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Phenylmethylethers are rather stable to acid conditions, and even in the case of cleavage, the methyl cation formed is less reactive in comparison with benzyl cations.
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25
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Kaiser, E.; Colescott, R. L.; Bossinger, C. D.; Cook, P. I. Anal. Biochem. 1970, 34, 594-598.
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