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7
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(a) Letot, E.; Koch, G.; Falchetto, R.; Bovermann, G.; Oberer, L.; Roth, H.-J. J. Comb. Chem. 2005, 7, 364.
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J. Comb. Chem
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Letot, E.1
Koch, G.2
Falchetto, R.3
Bovermann, G.4
Oberer, L.5
Roth, H.-J.6
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9
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27644478441
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(a) McAllister, L. A.; McCormick, R. A.; Procter, D. J. Tetrahedron 2005, 61, 11527.
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(2005)
Tetrahedron
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, pp. 11527
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McAllister, L.A.1
McCormick, R.A.2
Procter, D.J.3
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10
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18844401383
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(b) DiBlasi, C. M.; Macks, D. E.; Tan, D. S. Org. Lett. 2005, 7, 1777.
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(2005)
Org. Lett
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DiBlasi, C.M.1
Macks, D.E.2
Tan, D.S.3
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12
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0035351150
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(d) Tallarico, J. A.; Depew, K. M.; Pelish, H. E.; Westwood, N. J.; Lindsley, C. W.; Shair, M. D.; Schreiber, S. L.; Foley, M. A. J. Comb. Chem. 2001, 3, 312.
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(2001)
J. Comb. Chem
, vol.3
, pp. 312
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Tallarico, J.A.1
Depew, K.M.2
Pelish, H.E.3
Westwood, N.J.4
Lindsley, C.W.5
Shair, M.D.6
Schreiber, S.L.7
Foley, M.A.8
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13
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0033683359
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(e) Guiller, F.; Orain, D.; Bradley, M. Chem. Rev. 2000, 100, 2091.
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(2000)
Chem. Rev
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, pp. 2091
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Guiller, F.1
Orain, D.2
Bradley, M.3
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19
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33947610280
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The MM2 calculation of 4d (R4, Me) indicated that the dihedral angle formed by two planar chloro-substituted benzenes is 76.4°. The -CO-O- linkage and the ether methine proton would preferentially be in a common plane. Thus, the chloro atoms at ortho positions of two benzenes hinder the nucleophilc attack on the carbonyl group of the esters
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4 = Me) indicated that the dihedral angle formed by two planar chloro-substituted benzenes is 76.4°. The -CO-O- linkage and the ether methine proton would preferentially be in a common plane. Thus, the chloro atoms at ortho positions of two benzenes hinder the nucleophilc attack on the carbonyl group of the esters.
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20
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0004138760
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For solvolytic displacement reactions with TFA, see: a
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For solvolytic displacement reactions with TFA, see: (a) Milne, J. B. J. Chem. Non-Aqueous Solvents 1978, 5B, 1.
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(1978)
J. Chem. Non-Aqueous Solvents
, vol.5 B
, pp. 1
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Milne, J.B.1
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21
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33947608157
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(b) Nordlander, J. E.; Gruetzmacher, R. R.; Miller, F. Tetrahedron Lett. 1973, 12, 927.
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(1973)
Tetrahedron Lett
, vol.12
, pp. 927
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Nordlander, J.E.1
Gruetzmacher, R.R.2
Miller, F.3
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22
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33947591428
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Lantern (trademark of Mimotopes Pty, Ltd) is cylindrical in appearance and polystyrene grafted surface
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Lantern (trademark of Mimotopes Pty, Ltd) is cylindrical in appearance and polystyrene grafted surface.
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23
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33947582971
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1H NMR analysis, using an internal standard (1-bromo-4-methoxybenzene).
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1H NMR analysis, using an internal standard (1-bromo-4-methoxybenzene).
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24
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33845902543
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(a) Kurosu, M.; Mahapatra, S.; Narayanasamy, P.; Crick, D. C. Tetrahedron Lett. 2007, 48, 799.
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(2007)
Tetrahedron Lett
, vol.48
, pp. 799
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Kurosu, M.1
Mahapatra, S.2
Narayanasamy, P.3
Crick, D.C.4
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26
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33947599867
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In our hands, the synthesis of the same pentapetide with the HMBA linker employing the Fmoc-strategy afforded the desired product in ∼15
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In our hands, the synthesis of the same pentapetide with the HMBA linker employing the Fmoc-strategy afforded the desired product in ∼15%.
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27
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33947609674
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The same experiments were performed using 8b-C2 and we obtained compatible results that were observed with 8a-C2.
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The same experiments were performed using 8b-C2 and we obtained compatible results that were observed with 8a-C2.
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28
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32644445255
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Shin, D.-S.; Kim, D.-H.; Chung, W.-J.; Lee, Y.-S. J. Bio. Mol. Biol. 2005, 38, 517.
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(2005)
J. Bio. Mol. Biol
, vol.38
, pp. 517
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Shin, D.-S.1
Kim, D.-H.2
Chung, W.-J.3
Lee, Y.-S.4
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29
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33947591059
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The resin 8a-C2-Cl could be stored for over 20 days without decrease of the loading efficiency.
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The resin 8a-C2-Cl could be stored for over 20 days without decrease of the loading efficiency.
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30
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33947596182
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Phenolic alcohols reacted with 8a-C2-Cl-Me much faster than alkanols; greater than 90% selectivity was observed in the competition experiments with 15 and 19.
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Phenolic alcohols reacted with 8a-C2-Cl-Me much faster than alkanols; greater than 90% selectivity was observed in the competition experiments with 15 and 19.
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