Solid-phase syntheses of furopyridine and furoquinoline systems

Organic Letters

Volumn 6, Issue 9, 2004, Pages 1405-1408

  Cironi, Pablo ^a   Tulla Puche, Judit ^a,b   Barany, George ^b   Albericio, Fernando ^a   Álvarez, Mercedes ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b University of Minnesota   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUROPYRIDINE; FUROQUINOLINE; POTASSIUM CARBONATE; PYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DEPROTECTION REACTION; SOLID; SPECTROSCOPY; SUBSTITUTION REACTION; SYNTHESIS;

MOLECULAR CONFORMATION; PYRIDINES; QUINOLINES;

EID: 2442426336     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol049762f     Document Type: Article

References (36)

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32. Similar to ref 12, the required building blocks were made in three steps and 74-83% overall yields from commercially available 2-bromo-3-hydroxypyridine, 5-chloro-8-hydroxy-7-iodoquinoline, and o-iodoaniline. See Supporting Information for experimental details.
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34. 1H NMR after purification (overall yields are next to the structures). Further evidence for the structures was provided by masses 106 units higher than anticipated for the desired products shown in Table 1.
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