DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone: analysis by the 32P-postlabeling method

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 634, Issue 1-2, 2007, Pages 184-191

  Kanno, Takaharu ^a   Kawanishi, Masanobu ^a   Takamura Enya, Takeji ^b   Arlt, Volker M ^c   Phillips, David H ^c   Yagi, Takashi ^a  

^a Osaka City University   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

3 Nitrobenzanthrone; 32P postlabeling; DNA adducts; Human hepatoma cell

Indexed keywords

3 NITROBENZANTHRONE; CARCINOGEN;

AIRBORNE PARTICLE; ARTICLE; CARCINOGENESIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DNA ADDUCT; EXHAUST GAS; GENETIC TOXICOLOGY; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; THIN LAYER CHROMATOGRAPHY; URINALYSIS;

BENZ(A)ANTHRACENES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHROMATOGRAPHY, THIN LAYER; DNA ADDUCTS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; LIVER NEOPLASMS; PHOSPHORUS RADIOISOTOPES;

EID: 35448993185     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.07.002     Document Type: Article

References (31)

1. Enya T., Suzuki H., Watanabe T., Hirayama T., and Hisamatsu Y. 3-Nitrobenzanthrone, a powerful bacterial mutagen and suspected human carcinogen found in diesel exhaust and airborne particulates. Environ. Sci. Technol. 31 (1997) 2772-2776
2. Taga R., Tang N., Hattori T., Tamura K., Sakai S., Toriba A., Kizu R., and Hayakawa K. Direct-acting mutagenicity of extracts of coal burningderived particulates and contribution of nitropolycyclic aromatic hydrocarbons. Mutat. Res. 581 (2005) 91-95
3. Murahashi T., Watanabe T., Otake S., Hattori Y., Takamura T., Wakabayashi K., and Hirayama T. Determination of 3-nitrobenzanthrone in surface soil by normal-phase high-performance liquid chromatography with fluorescence detection. J. Chromatogr. A 992 (2003) 101-107
4. Watanabe T., Hasei T., Yoshifumi T., Otake S., Murahashi T., Takamura T., Hirayama T., and Wakabayashi K. Mutagenic activity and quantification of nitroarenes in surface soil in the Kinki region of Japan. Mutat. Res. 538 (2003) 121-131
5. Murahashi T., Iwanaga E., Watanabe T., and Hirayama T. Determination of the mutagen 3-nitrobenzanthrone in rainwater collected in Kyoto, Japan. J. Health Sci. 49 (2003) 386-390
6. Arlt V.M., Schmeiser H.H., Osborne M.R., Kawanishi M., Kanno T., Yagi T., Phillips D.H., and Takamura-Enya T. Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine. Int. J. Cancer 118 (2006) 2139-2146
7. Seidel A., Dahmann D., Krekeler H., and Jacob J. Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel exhaust. Int. J. Hyg. Environ. Health 204 (2002) 333-338
8. Lamy E., Kassie E., Gminski R., Schmeiser H.H., and Mersch-Sundermann V. 3-Nitrobenzanthrone (3-NBA) induced micronucleus formation and DNA damage in human hepatoma (HepG2) cells. Toxicol. Lett. 146 (2004) 103-109
9. Phousongphouang P.T., Grosovsky A.J., Eastmond D.A., Covarrubias M., and Arey J. The genotoxicity of 3-nitrobenzanthrone and the nitropyrene lactones in human lymphoblasts. Mutat. Res. 472 (2000) 93-103
10. Arlt V.M., Cole K.J., and Phillips D.H. Activation of 3-nitrobenzanthrone and its metabolites to DNA-damaging species in human B-lymphoblastoid MCL-5 cells. Mutagenesis 19 (2004) 149-156
11. Arlt V.M., Zhan L., Schmeiser H.H., Honma M., Hayashi M., Phillips D.H., and Suzuki T. DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse. Environ. Mol. Mutagen. 43 (2004) 186-195
12. Arlt V.M. 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence. Mutagenesis 20 (2005) 399-410
13. Nagy E., Johansson C., Zeisig M., and Moller L. Oxidative stress and DNA damage caused by the urban air pollutant 3-NBA and its isomer 2-NBA in human lung cells analysed with three independent methods. J. Chromatogr. Biomed. Life Sci. 827 (2005) 94-103
14. Kawanishi M., Enya T., Suzuki H., Takebe H., Matsui S., and Yagi T. Mutagenic specificity of a derivative of 3-nitrobenzanthrone in the supF shuttle vector plasmids. Chem. Res. Toxcol. 11 (1998) 1468-1473
15. Nagy E., Zeisig M., Kawamura K., Hisamatsu Y., Sugeta A., Adachi S., and Moller L. DNA-adduct and tumor formations in rats after intratracheal administration of the urban air pollutant 3-nitrobenzanthrone. Carcinogenesis 26 (2005) 1821-1828
16. Beland F.A., and Kadlubar F.F. Metabolic activation and DNA adducts of aromatic amines and nitroaromatic hydrocarbons. In: Cooper C.S., and Grover P.L. (Eds). Handbook of Experimental Pharmacology Chemical Carcinogenesis and Mutagenesis 94/I (1990), Springer-Verlag, Heidelberg 267-325
17. Beland F.A., and Marrques M.M. DNA adducts of nitropolycyclic aromatic hydrocarbons. DNA Adducts: Identification and Biological Significance (1994), International Agency for Research on Cancer, Lyon, France pp. 229-244
18. Hanna P.E., and Banks R.B. Arylhydroxylamines and arylhydroxamic acids: conjugation reactions. In: Anders M.W. (Ed). Bioactivation of Foreign Compounds (1985), Academic Press, New York 375-402
19. Kadlubar F.F., and Beland F.A. Chemical properties of ultimate carcinogenic metabolites of arylamines and arylamides. Polycyclic Hydrocarbons and Carcinogenesis (1985), American Chemical Society, Washington, DC pp. 341-370
20. Knasmuller S., Parzefall W., Sanyal R., Ecker S., Schwab C., Uhl M., Mersch-Sundermann V., Williamson G., Hietsch G., Langer T., Darroudi F., and Natarajan A.T. Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mutat. Res. 402 (1998) 185-202
21. Wilkening S., Stahl F., and Bader A. Comparison of primary human hepatocytes and hepatoma cell line HepG2 with regard to their biotransformation properties. Drug Metab. Dispos. 31 (2003) 1035-1042
22. Kawanishi M., Enya T., Suzuki H., Takebe H., Matsui S., and Yagi T. Postlabelling analysis of DNA adducts formed in human hepatoma cells treated with 3-nitrobenzanthrone. Mutat. Res. 470 (2000) 133-139
23. Enya T., Kawanishi M., Suzuki H., Matsui S., and Hisamatu Y. An unusual DNA adduct derived from the powerfully mutagenic environmental contaminant 3-nitrobenzanthrone. Chem. Res. Toxicol. 11 (1998) 1460-1467
24. Umemoto A., Kajikawa A., Tanaka M., Hamada K., Seraj M.J., Kubota A., Nakayama M., Kinouchi T., Ohnishi Y., Yamashita K., and Monden Y. Presence of mucosa-specific DNA adduct in human colon: possible implication for colorectal cancer. Carcinogenesis 15 (1994) 901-905
25. Takamura T., Kawanishi M., Nakagawa Y., Watanabe T., Hirayama T., Wakabayashi K., Hisamatsu Y., and Yagi T. Synthesis and characterization of DNA adducts from mutagenic 3-nitrobenzanthrone present in atmospheric environment. European Environmental Mutagen Society 34th Annual Meeting. Maastricht, The Netherlands (2004)
26. 32P-postlabeling analysis of DNA adducts derived from the environmental contaminant 3-nitrobenzanthrone. Chem. Res. Toxicol. 18 (2005) 1056-1070
27. 32P-postlabeling/polyacrylamide gel electrophoresis analysis: application to the detection of DNA adducts. Chem. Res. Toxicol. 15 (2002) 305-311
28. 32P-postlabeling analysis of aromatic carcinogen: DNA adducts. Cancer Res. 45 (1985) 5656-5662
29. 32P-Postlabeling analysis of bulky aromatic adducts. In: Phillips D.H., Castegnaro M., and Bartsch H. (Eds). Postlabelling Methods for Detection of DNA Adducts (1993), International Agency for Research on Cancer, Lyon, France 11-24
30. 32P-postlabeling. Int. J. Cancer 93 (2001) 450-454
31. Bieler C.A., Wiessler M., Erdinger L., Suzuki H., Enya T., and Schmeiser H.H. DNA adduct formation from the mutagenic air pollutant 3-nitrobenzanthrone. Mutat. Res. 439 (1999) 307-311