Evaluation of the genotoxic potential of the natural neurotoxin Tetrodotoxin (TTX) in a battery of in vitro and in vivo genotoxicity assays

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 634, Issue 1-2, 2007, Pages 14-24

  Guzmán, Antonio ^a   de Henestrosa, Antonio R Fernández ^a   Marín, Ana Paz ^a   Ho, Ahn ^b   Borroto, Jorge I González ^c   Carasa, Inés ^c   Pritchard, Lincoln ^d  

^a ESTEVE   (Spain)

^b Wex Pharmaceuticals Inc   (Canada)

^c RCC CIDA SA   (Spain)

^d HUNTINGDON LIFE SCIENCES   (United Kingdom)

Author keywords

Analgesic drug; Genotoxicity tests; Mutagenesis; Sodium channel blocker; Tetrodotoxin; TTX

Indexed keywords

NEUROTOXIN; TETRODOTOXIN;

AMES TEST; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CHROMOSOME ABERRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EVALUATION; FEMALE; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CULTURE; LIVER PERFUSION; LYMPHOCYTE; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; POST MITOCHONDRIAL FRACTION; PRECIPITATION; PRIORITY JOURNAL; RAT; RISK ASSESSMENT;

ANESTHETICS, LOCAL; ANIMALS; CHROMOSOME ABERRATIONS; DNA DAMAGE; HUMANS; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM; TETRODOTOXIN;

ANIMALIA; BACTERIA (MICROORGANISMS); RATTUS;

EID: 35448989221     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.05.016     Document Type: Article

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