Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35

Journal of Neuroscience Research

Volumn 85, Issue 14, 2007, Pages 3071-3078

  Sato, Ko ^a   Zhu, Ying Shan ^a   Saito, Taro ^a   Yotsumoto, Kensuke ^a   Asada, Akiko ^a   Hasegawa, Masato ^b   Hisanaga, Shin Ichi ^a  

^a TOKYO METROPOLITAN UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Inhibitor 2; Membrane association; Neuron; Protein kinase; Protein phosphatase 1

Indexed keywords

BRAIN EXTRACT; CYCLIN DEPENDENT KINASE 5; DETERGENT; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN P35;

ANIMAL TISSUE; ARTICLE; BRAIN; CORRELATION ANALYSIS; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FETUS; GEL FILTRATION CHROMATOGRAPHY; MEMBRANE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAT;

ADENOSINE TRIPHOSPHATE; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BRAIN; CYCLIN-DEPENDENT KINASE 5; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOPRECIPITATION; MEMBRANES; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PURINES; RATS; RATS, WISTAR;

EID: 35448956242     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21438     Document Type: Article

References (38)

1. Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings JrHC, Nairn AC, Greengard P. 1999. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 402:669-671.
2. Bibb JA, Nishi A, O'Callaghan JP, Ule J, Lan M, Snyder GL, Horiuchi A, Saito T, Hisanaga S, Czernik AJ, Nairn AC, Greengard P. 2001. Phosphorylation of protein phosphatase inhibitor-1 by Cdk5. J Biol Chem 276:14490-14497.
3. Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai LH. 1997. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18:29-42.
4. Cohen P. 1991. Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts. Methods Enzymol 201:389-398.
5. Dhavan R, Tsai LH. 2001. A decade of CDK5. Nat Rev Mol Cell Biol 2:749-759.
6. Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY. 2007. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci 10:67-76.
7. Goedert M, Jakes R, Crowther RA, Six J, Lubke U, Vandermeeren M, Cras P, Trojanowski JQ, Lee VM. 1993. The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phophorylation during development. Proc Natl Acad Sci U S A 90:5066-5070.
8. Hardie DG, Haystead TAJ, Sim ATR. 1991. Use of okadaic acid to inhibit protein phosphatases in intact cells. Methods Enzymol 201:469-476.
9. Hisanaga S, Saito T. 2003. The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator. Neurosignals 12:221-229.
10. Honkanen RE, Zwiller J, Moore RE, Daily SL, Khatra BS, Dukelow M, Boynton AL. 1990. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases. J Biol Chem 265:19401-19404.
11. Ishiguro K, Sato K, Takamatsu M, Park J, Uchida T, Imahori K. 1995. Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites. Neurosci Lett 202:81-84.
12. Kusakawa G, Saito T, Onuki R, Ishiguro K, Kishimoto T, Hisanaga S. 2000. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J Biol Chem 275:17166-17172.
13. Lew J, Huang QQ, Qi Z, Winkfein RJ, Aebersold R, Hunt T, Wang JH. 1994. A brain-specific activator of cyclin-dependent kinase 5. Nature 371:423-426.
14. Li T, Chalifour LE, Paudel HK. 2007. Phosphorylation of protein phosphatase 1 (PP1) by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J Biol Chem 282:6619-6628.
15. Matsushita M, Tomizawa K, Lu YF, Morizaki A, Tokuda M, Wang JH, Hatase O, Matsui H. 1996. Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35nck5a) in the developing rat cerebellum. Brain Res 734:319-322.
16. Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y. 1995. Hyperphosphorylation of tau in PHF. Neurobiol Aging 16:365-371.
17. Morgan DO. 1997. Cyclin-dependent kinases: engines, clocks, and microprocessors. Ann Rev Cell Dev Biol 13:261-291.
18. Ohshima T, Ward JM, Huh CG, Longenecker G, Veeranna , Pant HC, Brady RO, Martin LJ, Kulkarni AB. 1996. Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A 93:11173-11178.
19. Ohshima T, Ogura H, Tomizawa K, Hayashi K, Suzuki H, Saito T, Kamei H, Nishi A, Bibb JA, Hisanaga S, Matsui H, Mikoshiba K. 2005. Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 -/- mice. J Neurochem 94:917-925.
20. Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. 1999. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402:615-622.
21. Paglini G, Peris L, Diez-Guerra J, Quiroga S, Caceres A. 2001. The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic. EMBO Rep 2:1139-1144.
22. Poon RY, Lew J, Hunter T. 1997. Identification of functional domains in the neuronal Cdk5 activator protein. J Biol Chem 272:5703-5708.
23. Qi Z, Huang QQ, Lee KY, Lew J, Wang JH. 1995. Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain-specific activator. Kinase activation in the absence of Cdk5 phosphorylation. J Biol Chem 270:10847-10854.
24. Saito T, Onuki R, Fujita Y, Kusakawa G, Ishiguro K, Bibb JA, Kishimoto T, Hisanaga S. 2003. Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation. J Neurosci 23:1189-1197.
25. Sakaue F, Saito T, Sato Y, Asada A, Ishiguro K, Hasegawa M, Hisanaga S. 2005. Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. J Biol Chem 280:31522-31529.
26. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y. 2002. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35:907-920.
27. Shelton SB, Johnson GV. 2004. Cyclin-dependent kinase-5 in neurodegeneration. J Neurochem 88:1313-1326.
28. Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH. 1995. An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. J Biol Chem 270:26897-26903.
29. Tang D, Lee KY, Qi Z, Matsuura I, Wang JH. 1996. Neuronal Cdc2-like kinase: from cell cycle to neuronal function. Biochem Cell Biol 74:419-429.
30. Tang D, Wang JH, 1996. Cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activators. Prog Cell Cycle Res 2:205-216.
31. Tang X, Wang X, Gong X, Tong M, Park D, Xia Z, Mao Z. 2005. Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J Neurosci 25:4823-4834.
32. Tsai LH, Delalle I, Caviness JrVS, Chae T, Harlow E. 1994. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371:419-423.
33. Tsai LH, Lee MS, Cruz J. 2004. Cdk5, a therapeutic target for Alzheimer's disease? Biochim Biophys Acta 1697:137-142.
34. Uchida T, Ishiguro K, Ohnuma J, Takamatsu M, Yonekura S, Imahori K. 1994. Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain. FEBS Lett 355:35-40.
35. Wu DC, Yu YP, Lee NT, Yu AC, Wang JH, Han YF. 2000. The expression of Cdk5, p35, p39, and Cdk5 kinase activity in developing, adult, and aged rat brains. Neurochem Res 25:923-929.
36. Yamada M, Saito T, Sato Y, Kawai Y, Sekigawa A, Hamazumi Y, Asada A, Wada M, Doi H, Hisanaga S. 2007. Cdk5-p39 is a labile complex with the similar substrate specificity to Cdk5-p35. J Neurochem, in press.
37. Zhu YS, Saito T, Asada A, Maekawa S, Hisanaga S. 2005. Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation. J Neurochem 94:1535-1545.
38. Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Wu CL, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai LH. 2000. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron 26:633-646.