Targeted therapy: Part I. Signalling by tyrosine kinase receptors;Cześć I. Mechanizmy przesyłania sygnałów przy udziale receptorów o aktywności kinazy tyrozynowej

Wspolczesna Onkologia

Volumn 11, Issue 7, 2007, Pages

  Wiczyńska, Beata ^a   Rolski, Janusz ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

Non receptor tyrosine kinases; Receptor tyrosine kinases; Signal transduction pathways; Signaling molecules (ligands)

Indexed keywords

CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; GROWTH FACTOR; HORMONE; JANUS KINASE; LIGAND; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; SCATTER FACTOR RECEPTOR; SOMATOMEDIN; STAT PROTEIN; TYROSINE KINASE RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; PHENOTYPE; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SECOND MESSENGER; SIGNAL TRANSDUCTION;

EID: 35448948359     PISSN: 14282526     EISSN: 14282526     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 1995; 80: 225-36.
2. Tonks NK, Neel BG. From form to function: signaling by protein tyrosine phosphatases. Cell 1996; 87: 365-8.
3. Matozaki t, Kasuga M. Roles of protein-tyrosine phosphatases in growth factor signaling. Cell Signal 1996; 8: 13-9.
4. Robinson DR, Wu YM, Lin SF. The protein tyrosine kinase family of the human genome. Oncogene 2000; 19: 5548-57.
5. Adjei AA, Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Oncol 2005; 23: 5386-403.
6. Majsterek I, Pytel D, Błasiak J. Kinazy tyrozynowe. Nowy cel terapii przeciwnowotworowej. Post Biochem 2005; 51: 251-60.
7. Schlesinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103: 211-25.
8. Carpenter CJ, Cantley LC. Molecular target in oncology. In: Principles and practice of oncology 7th edithion. Devita VT, Hellman S, Rosenberg SA (eds). Lippincott Williams & Wilkins, Philadelphia 2005; 3: 73-83.
9. Barbacid M. Ras genes. Annu Rev Biochem 1987; 56: 779-827.
10. Adjei AA Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 2001; 193: 1062-74.
11. Macara IG, Lounsbury KM, Richards SA, McKiernan C, Bar-Sagi D. The Ras superfamily of GTPases. FASEB J 1996; 10: 625-30.
12. Jamroz-Wiśniewska A, Bełtowski J. Izoprenylacja białek. Post Biochem 2004; 50: 316-29.
13. Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 2002; 110: 669-72.
14. Vojtek AB, Der CJ. Increasing complexity of the Ras signaling pathway. J Biol Chem 1998; 273: 19925-8.
15. Gollob JA, Scott W, Carter C Kelley SL. Role of Raf kinase in cancer: Therapeutic potentiat of targeting the Raf/Mek/Eerk signal transduction pathway. Sem Oncol 2006; 33: 392-406.
16. Kolch W. Meaningful relationships: The regulation of the Ras/Raf/Mek/Erk pathway by protein interaction. Biochem J 2000; 351: 289-305.
17. Guan KL The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. Cell Signal 1994; 6: 581-9.
18. Stefanovsky VY, Pelletier G, Hannan R, Gagnon-Kugler T, Rothblum LI, Moss T. An immediate reponse of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. Mol Cell 2001; 8: 1063-73.
19. Faivre S, Djelloul S, Raymond E. New paradigms in anticancer the rapy: Targeting multiple signaling pathways with kinase inhibitors. Semin Oncol 2006; 33: 407-20.
20. Downward J. Mechanism and cosequences of activation of prote in kinase B/ Akt. Curr Opin Cell Biol 1998; 10: 262-7.
21. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000; 103: 253-62.
22. Newton AC. Protein kinase C: Structure, function, and regulation. J Biol Chem 1995; 270: 28495-8.
23. Serova M, Ghoul A, Benhadji KA, Cvitkovic E, Faivre S, Calvo F, Lokiec F, Raymond E. Preclinical and clinical development of novel agents that target the protein kinase C family. Semin Oncol 2006; 33: 466-78.
24. Sebolt-Leopold JS, Herrera R. Targeting the mitogen-activated protein kinase cascade to treat cancer. Nat Rev Cancer 2004; 4: 937-47.
25. Nishizuka Y. Protein kinase C and lipids signaling for sustained cellular responses. FASEB J 1995; 9: 484-69.
26. Ihle JN, Kerr IM. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 1995; 11: 69-74.