Rubrospinal neurons fail to respond to brain-derived neurotrophic factor applied to the spinal cord injury site 2 months after cervical axotomy

Experimental Neurology

Volumn 189, Issue 1, 2004, Pages 45-57

  Kwon, Brian K ^a,b   Liu, Jie ^a   Oschipok, Loren ^a   Teh, Joshua ^a   Liu, Zhuo Wei ^a   Tetzlaff, Wolfram ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER HOSPITAL AND HEALTH SCIENCES CENTRE   (Canada)

Author keywords

BDNF; Cervical axotomy; Rubrospinal neurons

Indexed keywords

ALPHA TUBULIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; NEUROMODULIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CERVICAL SPINAL CORD; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LABELING INDEX; MALE; MEDICAL ASSESSMENT; NERVE FIBER TRANSECTION; NERVE FUNCTION; NERVE REGENERATION; NERVE TRANSPLANTATION; NONHUMAN; PERIPHERAL NERVE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RED NUCLEUS; RUBROSPINAL TRACT; SPINAL CORD INJURY;

ANIMALS; AXOTOMY; BIOTIN; BRAIN STEM; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEXTRANS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; GAP-43 PROTEIN; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NERVE REGENERATION; NEURONS; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKB; RED NUCLEUS; SPINAL CORD INJURIES; STILBAMIDINES; TIME FACTORS; TUBULIN;

EID: 3543117852     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2004.05.034     Document Type: Article

References (46)

1. Ankeny D.P., Mctigue D.M., Guan Z., Yan Q., Kinstler O., Stokes B.T., Jakeman L.B. Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury. Exp. Neurol. 170:2001;85-100
2. Bamber N.I., Li H., Lu X., Oudega M., Aebischer P., Xu X.M. Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels. Eur. J. Neurosci. 13:2001;257-268
3. Blits B., Oudega M., Boer G.J., Bartlett B.M., Verhaagen J. Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function. Neuroscience. 118:2003;271-281
4. Bregman B.S., Kunkel-Bagden E., Schnell L., Dai H.N., Gao D., Schwab M.E. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature. 378:1995;498-501
5. Bregman B.S., Mcatee M., Dai H.N., Kuhn P.L. Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp. Neurol. 148:1997;475-494
6. Bregman B.S., Broude E., Mcatee M., Kelley M.S. Transplants and neurotrophic factors prevent atrophy of mature CNS neurons after spinal cord injury. Exp. Neurol. 149:1998;13-27
7. Coumans J.V., Lin T.T., Dai H.N., Macarthur L., Mcatee M., Nash C., Bregman B.S. Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J. Neurosci. 21:2001;9334-9344
8. Decherchi P., Gauthier P. Regrowth of acute and chronic injured spinal pathways within supra-lesional post-traumatic nerve grafts. Neuroscience. 101:2000;197-210
9. Diener P.S., Bregman B.S. Neurotrophic factors prevent the death of CNS neurons after spinal cord lesions in newborn rats. NeuroReport. 5:1994;1913-1917
10. Fernandes K.J., Tetzlaff W. Gene expression in axotomized neurons: identifying the intrinsic determinants of axonal growth. Ingoglia N.A., Murray M. Axonal Regeneration in the Central Nervous System. 2000;219-266 Marcel Dekker, New York
11. Fernandes K.J., Fan D.P., Tsui B.J., Cassar S.L., Tetzlaff W. Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. J. Comp. Neurol. 414:1999;495-510
12. Hill C.E., Beattie M.S., Bresnahan J.C. Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat. Exp. Neurol. 171:2001;153-169
13. Houle J.D., Jin Y. Chronically injured supraspinal neurons exhibit only modest axonal dieback in response to a cervical hemisection lesion. Exp. Neurol. 169:2001;208-217
14. Houle J.D., Tessler A. Repair of chronic spinal cord injury. Exp. Neurol. 182:2003;247-260
15. Houle J.D., Ye J.H. Survival of chronically-injured neurons can be prolonged by treatment with neurotrophic factors. Neuroscience. 94:1999;929-936
16. Ikeda O., Murakami M., Ino H., Yamazaki M., Nemoto T., Koda M., Nakayama C., Moriya H. Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord. Acta Neuropathol. (Berl). 102:2001;239-245
17. Ikeda O., Murakami M., Ino H., Yamazaki M., Koda M., Nakayama C., Moriya H. Effects of brain-derived neurotrophic factor (BDNF) on compression-induced spinal cord injury: BDNF attenuates down-regulation of superoxide dismutase expression and promotes up-regulation of myelin basic protein expression. J. Neuropathol. Exp. Neurol. 61:2002;142-153
18. Jakeman L.B., Wei P., Guan Z., Stokes B.T. Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury. Exp. Neurol. 154:1998;170-184
19. Jin Y., Fischer I., Tessler A., Houle J.D. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp. Neurol. 177:2002;265-275
20. Jones L.L., Tuszynski M.H. Chronic intrathecal infusions after spinal cord injury cause scarring and compression. Microsc. Res. Tech. 54:2001;317-324
21. King V.R., Bradbury E.J., Mcmahon S.B., Priestley J.V. Changes in truncated trkB and p75 receptor expression in the rat spinal cord following spinal cord hemisection and spinal cord hemisection plus neurotrophin treatment. Exp. Neurol. 165:2000;327-341
22. Kobayashi N.R., Fan D.P., Giehl K.M., Bedard A.M., Wiegand S.J., Tetzlaff W. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. J. Neurosci. 17:1997;9583-9595
23. Koda M., Murakami M., Ino H., Yoshinaga K., Ikeda O., Hashimoto M., Yamazaki M., Nakayama C., Moriya H. Brain-derived neurotrophic factor suppresses delayed apoptosis of oligodendrocytes after spinal cord injury in rats. J. Neurotrauma. 19:2002;777-785
24. Kwon B.K., Borisoff J.F., Tetzlaff W. Molecular targets for intervention in spinal cord injury. Mol. Interv. 2:2002;244-258
25. Kwon B.K., Liu J., Messerer C., Kobayashi N.R., Mcgraw J., Oschipok L., Tetzlaff W. Survival and regeneration of rubrospinal neurons 1 year after spinal cord injury. Proc. Natl. Acad. Sci. U. S. A. 99:2002;3246-3251
26. Kwon B.K., Liu J., Oschipok L., Tetzlaff W. Reaxotomy of chronically injured rubrospinal neurons results in only modest cell loss. Exp. Neurol. 177:2002;332-337
27. Li L., Xu Q., Wu Y., Hu W., Gu P., Fu Z. Combined therapy of methylprednisolone and brain-derived neurotrophic factor promotes axonal regeneration and functional recovery after spinal cord injury in rats. Chin. Med. J. (Engl.). 116:2003;414-418
28. Liebl D.J., Huang W., Young Y., Parada L.F. Regulation of Trk receptors following contusion of the rat spinal cord. Exp. Neurol. 167:2001;15-26
29. Liu Y., Kim D., Himes B.T., Chow S.Y., Schallert T., Murray M., Tessler A., Fischer I. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J. Neurosci. 19:1999;4370-4387
30. Liu Y., Himes B.T., Murray M., Tessler A., Fischer I. Grafts of BDNF-producing fibroblasts rescue axotomized rubrospinal neurons and prevent their atrophy. Exp. Neurol. 178:2002;150-164
31. Lu P., Blesch A., Tuszynski M.H. Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons. J. Comp. Neurol. 436:2001;456-470
32. Marino R.J., Ditunno J.F. Jr., Donovan W.H., Maynard F. Jr. Neurologic recovery after traumatic spinal cord injury: data from the Model Spinal Cord Injury Systems. Arch. Phys. Med. Rehabil. 80:1999;1391-1396
33. Namiki J., Kojima A., Tator C.H. Effect of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 on functional recovery and regeneration after spinal cord injury in adult rats. J. Neurotrauma. 17:2000;1219-1231
34. Novikova L.N., Novikov L.N., Kellerth J.O. Differential effects of neurotrophins on neuronal survival and axonal regeneration after spinal cord injury in adult rats. J. Comp. Neurol. 452:2002;255-263
35. Rasika S., Alvarez-Buylla A., Nottebohm F. BDNF mediates the effects of testosterone on the survival of new neurons in an adult brain. Neuron. 22:1999;53-62
36. Sayer F.T., Oudega M., Hagg T. Neurotrophins reduce degeneration of injured ascending sensory and corticospinal motor axons in adult rat spinal cord. Exp. Neurol. 175:2002;282-296
37. Schnell L., Schwab M.E. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature. 343:1990;269-272
38. Selzer M.E. Promotion of axonal regeneration in the injured CNS. Lancet Neurol. 2:2003;157-166
39. Sharma H.S., Westman J., Gordh T., Alm P. Topical application of brain derived neurotrophic factor influences upregulation of constitutive isoform of heme oxygenase in the spinal cord following trauma an experimental study using immunohistochemistry in the rat. Acta Neurochir., Suppl. 76:2000;365-369
40. Shumsky J.S., Tobias C.A., Tumolo M., Long W.D., Giszter S.F., Murray M. Delayed transplantation of fibroblasts genetically modified to secrete BDNF and NT-3 into a spinal cord injury site is associated with limited recovery of function. Exp. Neurol. 184:2003;114-130
41. Storer P.D., Houle J.D. betaII-tubulin and GAP 43 mRNA expression in chronically injured neurons of the red nucleus after a second spinal cord injury. Exp. Neurol. 183:2003;537-547
42. Storer P.D., Dolbeare D., Houle J.D. Treatment of chronically injured spinal cord with neurotrophic factors stimulates betaII-tubulin and GAP-43 expression in rubrospinal tract neurons. J. Neurosci. Res. 74:2003;502-511
43. Tetzlaff W., Alexander S.W., Miller F.D., Bisby M.A. Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43. J. Neurosci. 11:1991;2528-2544
44. Tobias C.A., Shumsky J.S., Shibata M., Tuszynski M.H., Fischer I., Tessler A., Murray M. Delayed grafting of BDNF and NT-3 producing fibroblasts into the injured spinal cord stimulates sprouting, partially rescues axotomized red nucleus neurons from loss and atrophy, and provides limited regeneration. Exp. Neurol. 184:2003;97-113
45. Von Meyenburg J., Brosamle C., Metz G.A., Schwab M.E. Regeneration and sprouting of chronically injured corticospinal tract fibers in adult rats promoted by NT-3 and the mAb IN-1, which neutralizes myelin-associated neurite growth inhibitors. Exp. Neurol. 154:1998;583-594
46. Ye J.H., Houle J.D. Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Exp. Neurol. 143:1997;70-81