Dietary polyunsaturated fatty acids modulate in vivo, antigen-driven CD4+ T-cell proliferation in mice

Journal of Nutrition

Volumn 134, Issue 8, 2004, Pages 1978-1983

  Anderson, Michele J ^a   Fritsche, Kevin L ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

CD4+ T cells; Diet; Fatty acids; Proliferation; TCR transgenic mice

Indexed keywords

CD4 ANTIGEN; FISH OIL; OMEGA 3 FATTY ACID; OVALBUMIN; POLYUNSATURATED FATTY ACID; SOYBEAN OIL; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FAT INTAKE; FLOW CYTOMETRY; IMMUNIZATION; IN VIVO STUDY; ISOGRAFT; LIPID DIET; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; SPLEEN CELL; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALIA; GLYCINE MAX; MUS MUSCULUS;

EID: 3543097515     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.8.1978     Document Type: Article

References (44)

1. Jolly, C. A., Jiang, Y. H., Chapkin, R. S. & McMurray, D. N. (1997) Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, inteleukin-2 secretion, and the formation of diacylglycerol and ceramide. J. Nutr. 127: 37-43.
2. Endres, S., Meydani, S. N., Ghorbani, R., Schindler, R. & Dinarello, C. A. (1993) Dietary supplementation with n-3 fatty acids suppresses interleukin-2 production and mononuclear cell proliferation. J. Leukoc. Biol. 54: 599-603.
3. Thies, F., Nebe-von-Caron, G., Powell, J. R., Yaqoob, P., Newsholme, E. A. & Calder, P. C. (2001) Dietary supplementation with γ-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. J. Nutr. 131: 1918-1927.
4. Purasiri, P., McKechnie, A., Heys, S. D. & Eremin, O. (1997) Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids. Immunology 92: 166-172.
5. Kew, S., Banerjee, T., Minihane, A. M., Finnegan, Y. E., Muggli, R., Albers, R., Williams, C. M. & Calder, P.C. (2003) Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. Am. J. Clin. Nutr. 77: 1287-1295.
6. Wallace, F. A., Miles, E. A. & Calder, P. C. (2003) Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. Br. J. Nutr. 89: 679-689.
7. Arrington, J. L., Chapkin, R. S., Switzer, K. C., Morris, J. S. & McMurray, D. N. (2001) Dietary n-3 polyunsaturated fatty acids modulate purified murine T-cell subset activation. Clin. Exp. Immunol. 125: 499-507.
8. Byleveld, M., Pang, G., Clancy, R. & Roberts, D. (2000) Fish oil feeding enhances lymphocyte proliferation but impairs virus-specific T lymphocyte cytotoxicity in mice following challenge with influenza virus. Clin. Exp. Immunol. 119: 287-292.
9. Calder, P. C. (1995) Fatty acids, dietary lipids and lymphocyte functions. Biochem. Soc. Trans. 23: 302-309.
10. Meydani, S. N., Lichtenstein, A. H., Comwall, S., Meydani, M., Goldin, B. R., Rasmussen, H., Dinarello, C. A. & Schaefer, E. J. (1993) Immunologic effects of national cholesterol education panel step-2 diets with and without fish-derived n-3 fatty acid enrichment. J. Clin. Investig. 92: 105-113.
11. Fowler, K. H., Chapkin, R. S. & McMurrray, D. N. (1993) Effects of purified dietary n-3 ethyl esters on murine T lymphocyte function. J. Immunol. 151: 5186-5180.
12. Kelley, D. S., Nelson, G. J., Branch, L. B., Taylor, P. C., Rivera, Y. M.., & Schmidt, P. C. (1992) Salmon diet and human immune status. Eur. J. Clin. Nutr. 46: 397-404.
13. Kobayashi, K., Kaneda, K. & Kasama, T. (2001) Immunopathogenesis of delayed-type hypersensitivity. Microsc. Res. Tech. 53: 241-245.
14. Dubey, C., Croft, M. & Swain, S. L. (1996) Naive and effector CD4 T cells differ in their requirements for T cell receptor versus costimulatory signals. J. Immunol. 157: 3280-3289.
15. Merica, R., Khoruts, A., Pape, K. A., Reinhardt, R. L. & Jenkins, M. K. (2000) Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. J. Immunol. 164: 4551-4557.
16. Casrouge, A., Beaudoing, E., Dalle, S., Pannetier, C., Kanellopoulos, J. & Kourilsky, P. (2000) Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J. Immunol. 164: 5782-5787.
17. Basson, M. A. & Zamoyska, R. (2000) Insights into T-cell development from studies using transgenic and knockout mice. Methods Mol. Biol. 134: 3-22.
18. Mondino, A., Khoruts, A. & Jenkins, M. K. (1996) The anatomy of T-cell activation and tolerance. Proc. Natl. Acad. Sci. U.S.A. 93: 2245-2252.
19. Pape, K. A., Kearney, E. R., Khoruts, A., Mondino, A., Merica, R., Chen, Z. M., Ingulli, E., White, J., Johnson, J. G. & Jenkins, M. K. (1997) Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cell for the study of T-cell activation in vivo. Immunol. Rev. 156: 67-78.
20. Reeves, P. G., Nielsen, F. H. & Fahey, G. C., Jr. (1993) AIN-93 purified diets for laboratory rodents: final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951.
21. Fritsche, K. L., Byrge, M. & Feng, C. (1999) Dietary omega-3 polyunsaturated fatty acids from fish oil reduce interleukin-12 and interferon-gamma production in mice. Immunol. Left. 65: 167-173.
22. Fritsche, K. L., Cassity, N. A. & Huang, S.-C. (1992) Dietary (n-3) fatty acid and vitamin E interactions in rats: effects on vitamin E status, immune cell prostaglandin E production and primary antibody response. J. Nutr. 122: 1009-1018.
23. Zinkernagel, R. M. (2002) Uncertainties-discrepancies in immunology. Immunol. Rev. 185: 103-125.
24. Jenkins, M. K., Khoruts, A., Ingulli, E., Mueller, D. L., McSorley, S. J., Reinhardt, R. L., Itano, A. & Pape, K. A. (2001) In vivo activation of antigen-specific CD4 T cells. Annu. Rev. Immunol. 19: 23-45.
25. Ise, W., Totsuka, M., Sogawa, Y., Ametani, A., Hachimura, S., Sato, T., Kumagai, Y., Habu, S. & Kaminogawa, S. (2002) Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen. J. Immunol. 168: 3242-3250.
26. + T-lymphocyte proliferation and interleukin-2 production are diminished by dietary (n-3) polyunsaturated fatty acids. J. Nutr. 132: 3293-3300.
27. Hoffeld, J. T. (1981) Agents which block membrane lipid peroxidation enhance mouse spleen cell immune activities in vitro: relationship to the enhancing activity of 2-mercaptoethanol. Eur. J. Immunol. 11: 371-376.
28. Jeffery, N. M., Sanderson, P., Sherrington, P., Newsholme, E. A. & Calder, P. C. (1996) The ratio of n-6 to n-3 polyunsaturated fatty acids in the rat diet alters serum lipid levels and lymphocyte functions. Lipids 31: 737-745.
29. Yaqoob, P., Newsholme, E. A. & Calder, P. C. (1994) The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology 82: 603-610.
30. Foulds, K. E., Zenewicz, L. A., Shedlock, D. J., Jiang, J., Troy, A. E. & Shen, H. (2002) Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J. Immunol. 168: 1528-1532.
31. Gett, A. V., Sallusto, F., Lanzavecchia, A. & Geginat, J. (2003) T cell fitness determined by signal strength. Nat. Immunol. 4: 355-360.
32. Murphy, K. M., Heimberger, A. B. & Loh, D. Y. (1990) Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRIo thymocytes in vivo. Science (Washington, DC) 250: 1720-1723.
33. Switzer, K. C., McMurray, D. N., Morris, J. S. & Chapkin, R. S. (2003) (n-3) Polyunsaturated fatty acids promote activation-induced cell death in murine T lymphocytes. J. Nutr. 133: 496-503.
34. Bradley, L. M., Watson, S. R. & Swain, S. L. (1994) Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin. J. Exp. Med. 180: 2401-2406.
35. Sanderson, P. & Calder, P. C. (1998) Dietary fish oil diminishes lymphocyte adhesion to macrophage and endothelial cell monolayers. Immunology 94: 79-87.
36. Hamann, A., Klugewitz, K., Austrup, F. & Jablonski-Westrich, D. (2000) Activation induces rapid and profound alterations in the trafficking of T cells. Eur. J. Immunol. 30: 3207-3218.
37. Reinhardt, R. L., Bullard, D. C., Weaver, C. T. & Jenkins, M. K. (2003) Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J. Exp. Med. 197: 751-762.
38. Novo, C. & Fonseca, E. (1987) Altered fatty acid membrane composition modifies lymphocyte localization in vivo. Cell. Immunol. 106: 387-396.
39. Calder, P. C., Bond, J. A., Bevan, S. J., Hunt, S. V. & Newsholme, E. A. (1991) Effect of fatty acids on the proliferation of concanavalin A-stimulated rat lymph node lymphocytes. Int. J. Biochem. 23: 579-588.
40. Calder, P. C., Bevan, S. J. & Newsholme, E. A. (1992) The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism. Immunology 75: 108-115.
41. Soyland, E., Nenseter, M. S., Braathen, L. & Drevon, C. A. (1993) Very long chain n-3 and n-6 polyunsaturated fatty acids inhibit proliferation of human T-lymphocytes in vitro. Eur. J. Clin. Investig. 23: 112-121.
42. Harbige, L. S. (2003) Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3. Lipids 38: 323-341.
43. Harbige, L. S. & Fisher, B.A.C. (2001) Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses. Proc. Nutr. Soc. 60: 449-456.
44. Hall, J. (1985) The study of circulating lymphocytes in vivo: a personal view of artifice and artifact. Immunol. Today 6: 149-152.