Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells

Archives of Dermatological Research

Volumn 296, Issue 2, 2004, Pages 67-73

  Bang, Bo ^a,c   Baadsgaard, Ole ^a   Skov, Lone ^a   Jäättelä, Marja ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Apoptosis; Caspase independent; UVB irradiation

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CA 074; CA 074 METHYL ESTER; CALPAIN; CALPASTATIN; CASPASE; CASPASE INHIBITOR; CATHEPSIN; CATHEPSIN B INHIBITOR; CYSTEINE CATHEPSIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; HELA CELL; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEINASE INHIBITION; ULTRAVIOLET B RADIATION;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; CALPAIN; CASPASES; CATHEPSINS; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; HELA CELLS; HUMANS; KERATINOCYTES; KETONES; LEUPEPTINS; PHOSPHOLIPASES A; ULTRAVIOLET RAYS;

EID: 3543067488     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-004-0473-4     Document Type: Article

References (32)

1. Armstrong BK, Kricker A (2001) The epidemiology of UV induced skin cancer. J Photochem Photobiol B 63:8-18
2. Franklin WA, Lo KM, Haseltine WA (1982) Alkaline lability of fluorescent photoproducts produced in ultraviolet light-irradiated DNA. J Biol Chem 257:13535-13543
3. Tornaletti S, Rozek D, Pfeifer GP (1993) The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer. Oncogene 8:2051-2057
4. Kim MY, Park HJ, Baek SC, Byun DG, Houh D (2002) Mutations of the p53 and PTCH gene in basal cell carcinomas: UV mutation signature and strand bias. J Dermatol Sci 29:1-9
5. Muramatsu T, Kobayashi N, Tada H, Yamaji M, Shirai T, Mori T, Ohnishi T (1992) Induction and repair of UVB-induced cyclobutane pyrimidine dimers and (6-4) photoproducts in organ-cultured normal human skin. Arch Dermatol Res 284:232-237
6. Dunkern TR, Fritz G, Kaina B (2001) Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation. Oncogene 20:6026-6038
7. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T, Brash DE (1994) Sunburn and p53 in the onset of skin cancer. Nature 372:773-776
8. Brash DE (1996) Cellular proofreading. Nat Med 2:525-526
9. Kulms D, Zeise E, Poppelmann B, Schwarz T (2002) DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene 21:5844-5851
10. Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-1316
11. Paroni G, Henderson C, Schneider C, Brancolini C (2001) Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3. J Biol Chem 276:21907-21915
12. Assefa Z, Vantieghem A, Garmyn M, Declercq W, Vandenabeele P, Vandenheede JR, Bouillon R, Merlevede W, Agostinis P (2000) p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis. J Biol Chem 275:21416-21421
13. Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273:32608-32613
14. Bossy-Wetzel E, Newmeyer DD, Green DR (1998) Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 17:37-49
15. Aragane Y, Kulms D, Metze D, Wilkes G, Poppelmann B, Luger TA, Schwarz T (1998) Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J Cell Biol 140:171-182
16. Kulms D, Poppelmann B, Yarosh D, Luger TA, Krutmann J, Schwarz T (1999) Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation. Proc Natl Acad Sci U S A 96:7974-7979
17. Saegusa J, Kawano S, Koshiba M, Hayashi N, Kosaka H, Funasaka Y, Kumagai S (2002) Oxidative stress mediates cell surface expression of SS-A/Ro antigen on keratinocytes. Free Radic Biol Med 32:1006-1016
18. Foghsgaard L, Wissing D, Mauch D, Lademann U, Bastholm L, Boes M, Elling F, Leist M, Jaattela M (2001) Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol 153:999-1010
19. Waterhouse NJ, Finucane DM, Green DR, Elce JS, Kumar S, Alnemri ES, Litwack G, Khanna K, Lavin MF, Watters DJ (1998) Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death Differ 5:1051-1061
20. Schotte P, Declercq W, Van Huffel S, Vandenabeele P, Beyaert R (1999) Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Lett 442:117-121
21. Vancompernolle K, Van Herreweghe F, Pynaert G, Van de Craen M, De Vos K, Totty N, Sterling A, Fiers W, Vandenabeele P, Grooten J (1998) Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity. FEBS Lett 438:150-158
22. Rozman-Pungercar J, Kopitar-Jerala N, Bogyo M, Turk D, Vasiljeva O, Stefe I, Vandenabeele P, Bromme D, Puizdar V, Fonovic M, Trstenjak-Prebanda M, Dolenc I, Turk V, Turk B (2003) Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity. Cell Death Differ 10:881-888
23. Turk B, Turk D, Turk V (2000) Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta 1477:98-111
24. Knepper-Nicolai B, Savill J, Brown SB (1998) Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspases. J Biol Chem 273:30530-30536
25. Wissing D, Mouritzen H, Egeblad M, Poirier GG, Jaattela M (1997) Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. Proc Natl Acad Sci U S A 94:5073-5077
26. Adam-Klages S, Schwandner R, Luschen S, Ussat S, Kreder D, Kronke M (1998) Caspase-mediated inhibition of human cytosolic phospholipase A2 during apoptosis. J Immunol 161:5687-5694
27. McCollum AT, Nasr P, Estus S (2002) Calpain activates caspase-3 during UV-induced neuronal death but only calpain is necessary for death. J Neurochem 82:1208-1220
28. Miyachi Y, Yoshimura N, Suzuki S, Hamakubo T, Kannagi R, Imamura S, Murachi T (1986) Biochemical demonstration and immunohistochemical localization of calpain in human skin. J Invest Dermatol 86:346-349
29. Hiwasa T, Arase Y, Kikuno K, Hasegawa R, Sugaya S, Kita K, Saido T, Yamamori H, Maki M, Suzuki N (2000) Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death Differ 7:531-537
30. Biggs JR, Yang J, Gullberg U, Muchardt C, Yaniv M, Kraft AS (2001) The human brm protein is cleaved during apoptosis: the role of cathepsin G. Proc Natl Acad Sci U S A 98:3814-3819
31. Cavarra E, Fimiani M, Lungarella G, Andreassi L, De SM, Mazzatenta C, Ciccoli L (2002) UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin. Biol Chem 383:199-206
32. Welss T, Sun J, Irving JA, Blum R, Smith AI, Whisstock JC, Pike RN, Von Mikecz A, Ruzicka T, Bird PI, Abts FH (2003) Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis. Biochemistry 42:7381-7389