Maintenance of bone mass and architecture in denning black bears (Ursus americanus)

Journal of Zoology

Volumn 263, Issue 4, 2004, Pages 359-364

  Pardy, Connor K ^a   Wohl, Gregory R ^a   Ukrainetz, Philip J ^a   Sawers, Andrew ^a   Boyd, Steven K ^a   Zernicke, Ronald F ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Black bear; Bone architecture; Bone mass; Denning; Micro computed tomography; Osteopenia; Ursus americanus

Indexed keywords

BEAR;

ANIMALIA; URSUS; URSUS AMERICANUS;

EID: 3543054147     PISSN: 09528369     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0952836904005412     Document Type: Article

References (31)

1. Aaron, J. E., Makins, N. B. & Sagreiya, K. (1987). The microanatomy of trabecular bone loss in normal aging men and women. Clin. Orthop. 215: 260-271.
2. Amling, M., Pogoda, P., Beil, F. T., Schilling, A. F., Holzmann, T., Priemel, M., Blicharski, D., Catala-Lehnen, P., Rueger, J. M., Ducy, P. & Karsenty, G. (2001). Central control of bone mass: brainstorming of the skeleton. Adv. exp. Med. Biol. 496: 85-94.
3. Anderson, S. A. & Cohn, S. H. (1985). Bone demineralization during space flight. Physiologist 28: 212-217.
4. Boyd, S. K., Müller, R. & Zernicke, R. F. (2002). Mechanical and architectural bone adaptation in early stage experimental osteoarthritis. J. Bone Miner. Res. 17: 687-94.
5. Burguera, B., Hofbauer, L. C., Thomas, T., Gori, F., Evans, G. L., Khosla, S., Riggs, B. L. & Turner, R. T. (2001). Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology 142: 2100-2103.
6. Cann, C. E., Adachi, R. R. & Holton, E. M. (1980). Bone resorption and calcium absorption in rats during spaceflight. Physiologist 23 (Suppl. 6): 83-86.
7. Chantraine, A., Nusgens, B. & Lapiere, C. M. (1986). Bone remodeling during development of osteoporosis in paraplegia. Calcif. Tissue Int. 38: 323-327.
8. Clouston, W. M. & Lloyd, H. M. (1987). Immobilization-induced hyercalcemia and regional osteoporosis. Clin. Orthop. 216: 247-252.
9. David, M., Nelson, R. & Alt, G. (1988). Study of calcium, phosphorous, alkaline phosphatase and hydroxyproline in black bears. Proc. Fed. Am. Soc. exp. Biol. 2: 3180.
10. Deitrick, J. E., Whedon, G. D. & Shorr, E. (1948). Effects of immobilization upon various metabolic and physiologic functions in normal man. Am. J. Med. 4: 3-36.
11. Ding, M. & Hvid, I. (2000). Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous bone. Bone 26: 291-295.
12. Fair, J. & Rogers, L. (1990). The great American bear. Minocqua, Wisconsin: North Word Press.
13. Floyd, T., Nelson, R. A. & Wynne, G. F. (1990). Calcium and bone metabolic homeostasis in active and hibernation black bears (Ursus americanus). Clin. Orthop. 255: 301-309.
14. Goldstein, S. A. (1987). The mechanical properties of trabecular bone: dependence on anatomic location and function. J. Biomech. 20: 1055-1061.
15. Gordeladze, J. O., Drevon, C. A., Syversen, U. & Reseland, J. E. (2002). Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis and osteoclastic signaling. J. Cell Biochem. 85: 825-836.
16. Harlow, H. J., Lohuis, T., Beck, T. & Iaizzo, P. A. (2001). Muscle strength in overwintering bears. Nature (Lond.) 409: 997.
17. Hildebrand, T. & Ruegsegger, P. (1997). Quantification of bone microarchitecture with the structure model index. Comp. Meth. Biomech. Biomed. Eng. 1: 15-23.
18. Holloway, W. R., Collier, F. M., Aitken, C. J., Myers, D. E., Hodge, J. M., Malakellis, M., Gough, T. J., Collier, G. R. & Nicholson, G. C. (2002). Leptin inhibits osteoclast generation. J. Bone Miner. Res. 17: 200-209.
19. Jee, W. S. & Ma, Y. (1999). Animal models of immobilization osteopenia. Morphologie 83: 25-34.
20. Judex, S., Donahue, L. R. & Rubin, C. (2002). Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J. 16: 1280-1282.
21. Keaveny, T. M., Morgan, E. F., Niebur, G. L. & Yeh, O. C. (2001). Biomechanics of trabecular bone. Annu. Rev. Biomed. Eng. 3: 307-333.
22. Lundberg, D. A., Nelson, R. A., Wahner, H. W. & Jones, J. D. (1976). Protein metabolism in black bears before and during hibernation. Mayo Clin. Proc. 51: 716-722.
23. Maor, G., Rochwerger, M., Segev, Y. & Phillip, M. (2002). Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. J. Bone Miner. Res. 17: 1034-1043.
24. Minaire, P., Meunier, P., Edoudard, C., Bernard, J., Courpron, P. & Bourret, J. (1974). Quantitative histological data on disuse osteoporosis: comparison with biological data. Calcif. Tissue Res. 17: 57-73.
25. Morgan, E. F. & Keaveny, T. M. (2001). Dependence of yield strain of human trabecular bone on anatomic site. J. Biomech. 34: 569-577.
26. Mundy, R. A. (1987). Bone resorption and turnover in health and disease. Bone 8 (Suppl. 1): S9-S16.
27. Nelson, R. A., Folk, G. E., Pfeiffer, E. W., Crai-Ghead, J. J., Jonkel, C. J. & Steiger, D. L. (1983). Behaviour and biochemistry and hibernation in black, grizzly and polar bears. In Proceedings of the 5th International Conference of Bear Research and Management (1980): 284-290. Knoxville, TN: International Association for Bear Research and Management.
28. Ozata, M. (2002). Different presentation of bone mass in mice and humans with congenital leptin deficiency. J. clin. Endocrinol. Metab. 87: 951.
29. Raisz, L. G. (1988). Local and systematic factors in the pathogenesis of osteoporosis. N. Engl. J. Med. 318: 818-28.
30. Rubin, C., Xu, G. & Judex, S. (2001). The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. FASEB J. 15: 2225-2229.
31. Simkin, A., Ayalon, J. & Leichter, I. (1987). Increased trabecular bone density due to bone-loading exercises in post-menopausal osteoporotic women. Calcif. Tissue Int. 40: 59-63.