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Typical procedure for the synthesis of 5-alkoxy-4-halo-2-alkylpyridazin- 3(2H)-ones 3. A mixture of 2 (0.4 mmol), potassium carbonate (0.8 mmol) and the corresponding alkyl halide (0.7 mmol) in the corresponding alcohol (8 mL) was flushed with argon for 5 min. The suspension was stirred and heated under reflux until the starting material had been consumed. The mixture was cooled and the suspension was concentrated to dryness under reduced pressure. The resulting solid was washed with water, filtered off and then purified by crystallization or column chromatography on silica gel.
-
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32
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3542991147
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note
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Typical procedure for the synthesis of 5-alkoxy-2-alkyl-pyridazin-3(2H)- ones 3. A mixture of 2 (0.4 mmol), potassium carbonate (0.8 mmol), a catalytic amount of palladium on charcoal, the alkyl halide (0.7 mmol) in the corresponding alcohol (8 mL) was flushed with hydrogen for 5 min. The suspension was stirred and heated under reflux under a hydrogen atmosphere until the starting material had been consumed (24-36 h). The mixture was cooled and the suspension was concentrated to dryness under reduced pressure. The resulting solid was washed with water, filtered off and then purified by crystallization or column chromatography on silica gel.
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3543011681
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2O (10 mL) was flushed with argon for 5 min. The suspension was stirred and heated under reflux until the starting material had been consumed. The mixture was cooled and the suspension was concentrated to dryness under reduced pressure. The resulting solid was washed with water, filtered off and then purified by crystallization or column chromatography on silica gel.
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39
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