Resin-bound thiophenols as S(N)AR-labile linkers: Application to the solid phase synthesis of aminopyridazines

Tetrahedron Letters

Volumn 40, Issue 45, 1999, Pages 7975-7978

  Parrot, Isabelle ^a   Wermuth, Camille Georges ^a   Hibert, Marcel ^a  

^a Laboratoire de Pharmacochimie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; AMINOPYRIDAZINE DERIVATIVE; PYRIDAZINE DERIVATIVE; SULFONE; THIOPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; SOLID;

EID: 0033527607     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01533-6     Document Type: Article

References (15)

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6. Argonaut Technologies, 887 Industrial Road, Suite G, San Carlos, CA 94070.
7. We have synthesized the PS-para-thiophenol resin starting from an aminomethylated polystyrene resin. (equation presented)
8. -1.
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14. Yields of 2 have been determined as follows: Cleavage is followed by IR (partial or total disappearance of pyridazine absorption bands) and the amount of 2 recovered is measured by weighing (more than 300 mg of resin per experiment is used). The yield is deduced, based on the theoretical loading of commercial resin.
15. Parrot, I.; Rival, Y.; Wermuth, C. G. Synthesis 1999, 7, 1163-1168.