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Maksymowych WP, Rahman P, Reeve JP, et al.: Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations. Arthritis Rheum 2006, 54:974-985. This Canadian study further validates the British study that documented a major gene(s) within the IL-1 gene cluster. In this study, multipoint LD mapping noted a strong peak just centromeric to IL-1α.
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