Focal adhesion kinase mediates human leukocyte histocompatibility antigen class II-induced signaling in gingival fibroblasts

Journal of Periodontal Research

Volumn 42, Issue 6, 2007, Pages 572-579

  Yoshizawa, S ^a   Meguro, M ^a   Ohyama, H ^b   Takeuchi Hatanaka, K ^a   Matsushita, S ^c   Takashiba, S ^a   Nishimura, F ^a,d  

^a OKAYAMA UNIVERSITY   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Focal adhesion kinase; Gingival fibroblast; Human leukocyte antigen II; Luteolin

Indexed keywords

FOCAL ADHESION KINASE; HLA D ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 6; LUTEOLIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; GINGIVA; HUMAN; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MICROARRAY; SIGNAL TRANSDUCTION;

CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINE CCL5; FIBROBLASTS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GINGIVA; HLA-D ANTIGENS; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-6; LUTEOLIN; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; SIGNAL TRANSDUCTION;

EID: 35349008654     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2007.00985.x     Document Type: Article

References (21)

1. Shimabukuro Y, Murakami S, Okada H. Antigen-presenting-cell function of interferon gamma-treated human gingival fibroblasts. J Periodont Res 1996 31 : 217 228.
2. Ohyama H, Nishimura F, Meguro M, Takashiba S, Murayama Y, Matsushita S. Counter-antigen presentation: fibroblasts produce cytokines by signalling through HLA class II molecules without inducing T-cell proliferation. Cytokine 2002 17 : 175 181.
3. Meguro M, Nishimura F, Ohyama H, Takashiba S, Murayama Y, Matsushita S. Ligation of IFN-gamma-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun N-terminal kinase (JNK) pathway. Cytokine 2003 22 : 107 115.
4. Wade WF, Davoust J, Salamero J, Andre P, Watts TH, Cambier JC. Structural compartmentalization of MHC class II signaling function. Immunol Today 1993 14 : 539 546.
5. Huang YT, Lee LT, Lee PP, Lin YS, Lee MT. Targeting of focal adhesion kinase by flavonoids and small-interfering RNAs reduces tumor cell migration ability. Anticancer Res 2005 25 : 2017 2025.
6. Xagorari A, Roussons C, Papapetropoulos A. Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin. Br J Pharmacol 2002 136 : 1058 1064.
7. Kimata M, Shichijo M, Miura T, Serizawa I, Inagaki N, Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mast cells. Clin Exp Allergy 2000 30 : 501 508.
8. Kim TJ, Kim JH, Jin YR, Yun YP. The inhibitory effect and mechanism of luteolin 7-glucoside on rat aortic vascular smooth muscle cell proliferation. Arch Pharm Res 2006 29 : 67 72.
9. Lee WJ, Wu LF, Chen WK, Wang CJ, Tseng TH. Inhibitory effect of luteolin on hepatocyte growth factor/scatter factor-induced HepG2 cell invasion involving both MAPK/ERKs and PI3K-Akt pathways. Chem Biol Interact 2006 160 : 123 133.
10. Kim JA, Kim DK, Kang OH et al. Inhibitory effect of luteolin on TNF-alpha-induced IL-8 production in human colon epithelial cells. Int Immunopharmacol 2005 5 : 209 217.
11. Bagli E, Stefaniotou M, Morbidelli L et al. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3′-kinase activity. Cancer Res 2004 64 : 7936 7946.
12. Hirano T, Higa S, Arimatsu J et al. Luteolin, a flavonoid, inhibits AP-1 activation by basophils. Biochem Biophys Res Commun 2006 340 : 1 7.
13. Schlaepfer DD, Hauck CR, Sieg DJ. Signaling through focal adhesion kinase. Prog Biophys Mol Biol 1999 71 : 435 478.
14. Igishi T, Fukuhara S, Patel V, Katz BZ, Yamada KM, Gutkind JS. Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. J Biol Chem 1999 274 : 30738 30746.
15. King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogenactivated protein kinase pathway activation. Mol Cell Biol 1997 17 : 4406 4418.
16. Altomonte M, Visintin A, Tecce R et al. Targeting of HLA-DR molecules transducer agonistic functional signals in cutaneous melanoma. J Cell Physiol 2004 200 : 272 276.
17. Etienne S, Adamson P, Greenwood J, Strosberg AD, Cazaubon S, Couraud PO. ICAM-1 signaling pathways associated with Rho activation in microvascular brain endothelial cells. J Immunol 1998 161 : 5755 5761.
18. Anfosso F, Bardin N, Frances V et al. Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125 (FAK). J Biol Chem 1998 273 : 26852 26856.
19. Jin YP, Du Singh RPZY, Rajasekaran A, Rozengurt E, Reed E. Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, Paxillin, and focal adhesion kinase in an actin-dependent manner. J Immunol 2002 168 : 5415 5423.
20. Lepin EJ, Jin YP, Barwe SP, Rozengurt E, Reed EF. HLA class I signal transduction is dependent on Rho GTPase and ROK. Biochem Biophys Res Commun 2004 323 : 213 217.
21. Hendriks JJ, Alblas J, van der Pol SM, van Tol EA, Dijkstra CD, de Vries HE. Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis. J Exp Med 2004 200 : 1667 1672.