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2). The cost of the copper-catalyzed reaction is $150 (iodobenzene) + $3 (CuI; Aldrich prices). An expensive ligand is usually used for palladium-catalyzed reactions.
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2). The cost of the copper-catalyzed reaction is $150 (iodobenzene) + $3 (CuI; Aldrich prices). An expensive ligand is usually used for palladium-catalyzed reactions.
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Cu-catalyzed reaction of indoles with tetrahydroisoquinolines: (c) Li, Z.; Li, C.-J. J. Am. Chem. Soc. 2005, 127, 6968.
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Heterocycle arylation under Pd, by Pd/Cu catalysis, or by using several equivalents of Cu: Pivsa-Art, S.; Satoh, T.; Kawamura, Y.; Miura, M.; Nomura, M. Bull. Chem. Soc. Jpn. 1998, 71, 467.
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Palladium-catalyzed pyridine oxide arylation: Campeau, L.-C.; Rousseaux, S.; Fagnou, K. J. Am. Chem. Soc. 2005, 127, 18020.
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Silver-benzyne complex reactions with arene nucleophiles: (a) Friedman, L. J. Am. Chem. Soc. 1967, 89, 3071.
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Review about Cu-catalyzed nucleophilic substitution: (b) Lindley, J. Tetrahedron 1984, 40, 1433.
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Aryne substitution: (c) Pellissier, H.; Santelli, M. Tetrahedron 2003, 59, 701.
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Benzyne reactions with Pd species: (d) Liu, Z.; Larock, R. C. J. Org. Chem. 2007, 72, 223.
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Arylation of 4,5-dimethylthiazole by p-tolyl bromide under conditions of Scheme IA affords a mixture of m-tolyl- and p-tolylderivatives. See Supporting Information for details.
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Arylation of 4,5-dimethylthiazole by p-tolyl bromide under conditions of Scheme IA affords a mixture of m-tolyl- and p-tolylderivatives. See Supporting Information for details.
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