An overlapping binding site in the CYP7A1 promoter allows activation of FXR to override the stimulation by LXRα

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 293, Issue 4, 2007, Pages

  Shang, Quan ^a   Pan, Luxing ^b   Saumoy, Monica ^a   Chiang, John Y L ^c   Tint, G Stephen ^a,b   Salen, Gerald ^a   Xu, Guorong ^a,b  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Northeastern Ohio Medical University   (United States)

Author keywords

Cholesterol 7 hydroxylase; Farnesoid X receptor; Fetoprotein transcription factor; Liver X receptor ; LXR binding site; Regulation; Short heterodimer partner

Indexed keywords

CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; FETOPROTEIN; HETERODIMER; LIVER X RECEPTOR ALPHA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BINDING SITE; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYP7A1 GENE; GEL MOBILITY SHIFT ASSAY; GENE; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RABBIT; RECEPTOR UPREGULATION;

ANIMALS; BINDING SITES; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLESTEROL, DIETARY; DNA-BINDING PROTEINS; MALE; PROMOTER REGIONS (GENETICS); RABBITS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 35348987537     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00209.2007     Document Type: Article

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