Autologous Cell-Based Therapy for Tendon and Ligament Injuries

Clinical Techniques in Equine Practice

Volumn 6, Issue 3, 2007, Pages 198-208

  Sutter, W Wesley ^a  

^a Ocala Equine Hospital   (United States)

Author keywords

cell based therapies; platelet rich plasma; regenerative cells; stem cells

Indexed keywords

EQUIDAE;

EID: 35348981246     PISSN: 15347516     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ctep.2007.08.006     Document Type: Article

References (45)

1. Bordignon C., Carlo-Stella C., Colombo M.P., et al. Cell therapy: achievements and perspectives. Haematologica 84 (1999) 1110-1149
2. Fortier L.A. Stem cells: classifications, controversies, and clinical applications. Vet Surg 34 (2005) 415-423
3. Bidula J., Boehm C., Powell K., et al. Osteogenic progenitors in bone marrow aspirates from smokers and nonsmokers. Clin Orthop Relat Res 442 (2006) 252-259
4. Vidal M.A., Kilroy G.E., Johnson J.R., et al. Cell growth characteristics and differentiation frequency of adherent equine bone marrow-derived mesenchymal stromal cells: adipogenic and osteogenic capacity. Vet Surg 35 (2006) 601-610
5. Herthel D.J. Enhanced suspensory ligament healing in 100 horses by stem cells and other bone marrow components. Proc Am Assoc Equine Pract (2001) 319-321
6. Smith R.K., Korda M., Blunn G.W., et al. Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment. Equine Vet J 35 (2003) 99-102
7. Smith J.J., Ross M.W., and Smith R.K. Anabolic effects of acellular bone marrow, platelet rich plasma, and serum on equine suspensory ligament fibroblasts in vitro. Vet Comp Orthop Traumatol 19 (2006) 43-47
8. Sellon D.C. How to obtain a diagnostic bone marrow sample from the sternum of an adult horse. Proc Am Assoc Equince Pract 54 (2006) 621-625
9. Muschler G.F., Boehm C., and Easley K. Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am 79 (1997) 1699-1709
10. McDuffee L.A., and Anderson G.I. In vitro comparison of equine cancellous bone graft donor sites and tibial periosteum as sources of viable osteoprogenitors. Vet Surg 32 (2003) 455-463
11. Pietrzak W.S., and Eppley B.L. Platelet rich plasma: biology and new technology. J Craniofac Surg 16 (2005) 1043-1054
12. Borzini P., and Mazzucco L. Tissue regeneration and in loco administration of platelet derivatives: clinical outcome, heterogeneous products, and heterogeneity of the effector mechanisms. Transfusion 45 (2005) 1759-1767
13. Schnabel L.V., Mohammed H.O., Miller B.J., et al. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 25 (2007) 230-240
14. Sutter W.W., Kaneps A.J., and Bertone A.L. Comparison of hematologic values and transforming growth factor-beta and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood. Am J Vet Res 65 (2004) 924-930
15. Marx R.E. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 62 (2004) 489-496
16. Kawase T., Okuda K., Saito Y., et al. In vitro evidence that the biological effects of platelet-rich plasma on periodontal ligament cells is not mediated solely by constituent transforming-growth factor-beta or platelet-derived growth factor. J Periodontol 76 (2005) 760-767
17. Anitua E., Sanchez M., Nurden A.T., et al. Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities. J Biomed Mater Res A 77 (2006) 285-293
18. Kawase T., Okuda K., Wolff L.F., et al. Platelet-rich plasma-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. J Periodontol 74 (2003) 858-864
19. Chambers R.C., Dabbagh K., McAnulty R.J., et al. Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem J 333 (1998) 121-127
20. Chang M.C., Chan C.P., Wu H.L., et al. Thrombin-stimulated growth, clustering, and collagen lattice contraction of human gingival fibroblasts is associated with its protease activity. J Periodontol 72 (2001) 303-313
21. Fang Q., Liu X., Abe S., et al. Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon. Eur Respir J 24 (2004) 918-924
22. Giacco F., Perruolo G., D'Agostino E., et al. Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1. FASEB J 20 (2006) 2402-2404
23. Murray M.M., Forsythe B., Chen F., et al. The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res 24 (2006) 508-515
24. Aspenberg P., and Virchenko O. Platelet concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand 75 (2004) 93-99
25. Virchenko O., and Aspenberg P. How can one platelet injection after tendon injury lead to a stronger tendon after 4 weeks?. Interplay between early regeneration and mechanical stimulation. Acta Orthop 77 (2006) 806-812
26. Sanchez M., Anitua E., Azofra J., et al. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 35 (2007) 245-251
27. Anitua E., Andia I., Sanchez M., et al. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 23 (2005) 281-286
28. Haynesworth S.E., Kadiyala S., Liang L.N., et al. Mitogenic stimulation of human mesnechymal stem cells by platelet release suggest a mechanism for enhancement of bone repair by platelet concentrates (2002) Poster presented at: 48th Annual Meeting of the Orthopedic Research Society; March 6; New Orleans, LA
29. Weibrich G., Kleis W.K., Buch R., et al. The Harvest Smart PRePTM system versus the Friadent-Schutze platelet-rich plasma kit. Clin Oral Implants Res 14 (2003) 233-239
30. Lozano M.L., Perez-Ceballos E., Rivera J., et al. Evaluation of a new whole-blood filter that allows preparation of platelet concentrates by platelet-rich plasma methods. Transfusion 43 (2003) 1723-1728
31. Caplan A.I. Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng 11 (2005) 1198-1211
32. Shimode K., Iwasaki N., Majima T., et al. Bone marrow stromal cells act as feeder cells for tendon fibroblasts through soluble factors. Tissue Eng 13 (2007) 333-341
33. McGonagle D., De B.C., Arnold P., et al. Lessons from musculoskeletal stem cell research: the key to successful regenerative medicine development. Arthritis Rheum 56 (2007) 714-721
34. Kajikawa Y., Morihara T., Watanabe N., et al. GFP chimeric models exhibited a biphasic pattern of mesenchymal cell invasion in tendon healing. J Cell Physiol 210 (2007) 684-691
35. Barry F.P., and Murphy J.M. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 36 (2004) 568-584
36. Murphy J.M., Fink D.J., Hunziker E.B., et al. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 48 (2003) 3464-3474
37. Rombouts W.J., and Ploemacher R.E. Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia 17 (2003) 160-170
38. United States. FDA. Centers for Biologics Evaluation and Research. Guidance on applications for products comprised of living autologous cells manipulated ex vivo and intended for structural repair or reconstruction (1996) Washington: GPO
39. Mannello F., and Tonti G.A. No breakthroughs for human mesenchymal and embryonic stem cell culture: conditioned medium, feeder layer or feeder-free; medium with foetal calf serum, human serum or enriched plasma; serum-free, serum replacement nonconditioned medium or ad-hoc formula?. All that glitters is not gold!. Stem Cells 25 (2007) 1603-1609
40. Shahdadfar A., Fronsdal K., Haug T., et al. In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability. Stem Cells 23 (2005) 1357-1366
41. Mauney J.R., Volloch V., and Kaplan D.L. Role of adult mesenchymal stem cells in bone tissue engineering applications: current status and future prospects. Tissue Eng 11 (2005) 787-802
42. Baksh D., Davies J.E., and Zandstra P.W. Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesion-independent survival and expansion. Exp Hematol 31 (2003) 723-732
43. Sotiropoulou P.A., Perez S.A., Salagianni M., et al. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells 24 (2006) 462-471
44. Khakoo A.Y., and Finkel T. Endothelial progenitor cells. Annu Rev Med 56 (2005) 79-101
45. Hescheler J., Weltz A., and Fleishman B.K. Searching for reputability: first randomized study on bone-marrow transplantation in the heart. Lancet 364 (2004) 121-122