Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1

FASEB Journal

Volumn 20, Issue 13, 2006, Pages

  Giacco, Ferdinando ^a   Perruolo, Giuseppe ^a   D'Agostino, Elio ^a   Fratellanza, Giorgio ^a   Perna, Enzo ^a   Misso, Saverio ^a   Saldalamacchia, Gennaro ^b   Oriente, Francesco ^a   Fiory, Francesca ^a   Miele, Claudia ^a   Formisano, Salvatore ^a   Beguinot, Francesco ^a   Formisano, Pietro ^a,b  

^a Istituto di Endocrinologia ed Oncologia Sperimentale del CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Akt PKB; Diabetic foot; ERK; Growth factor receptors; Tyrosine kinase

Indexed keywords

6,7 DIMETHOXY 2 PHENYLQUINOXALINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; THROMBIN ACTIVATED PLATELET; THROMBIN DERIVATIVE; THROMBIN;

ARTICLE; AUTOCRINE EFFECT; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC PATIENT; DNA SYNTHESIS; DRUG INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FIBROBLAST; SKIN ULCER; THROMBOCYTE; BIOSYNTHESIS; CELL DIVISION; CULTURE TECHNIQUE; CYTOLOGY; FIBROBLAST; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; METABOLISM; PHYSIOLOGY; SKIN; THROMBOCYTE ACTIVATION;

BLOOD PLATELETS; CELL CULTURE TECHNIQUES; CELL DIVISION; FIBROBLASTS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; PLATELET ACTIVATION; PROTO-ONCOGENE PROTEINS C-AKT; SKIN; SKIN PHYSIOLOGY; THROMBIN;

EID: 33845649724     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6104fje     Document Type: Article

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