Microwave-assisted synthesis of substituted 2,4-diarylthiazoles and their evaluation as anticancer agents

Letters in Drug Design and Discovery

Volumn 4, Issue 7, 2007, Pages 464-466

  Romagnoli, Romeo ^a   Baraldi, Pier Giovanni ^a   Lopez, Olga Cruz ^a   Carrion, Maria Dora ^a   Cara, Carlota Lopez ^a   Preti, Delia ^a   Tabrizi, Mojgan Aghazadeh ^a   Balzarini, Jan ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anticancer agents; Microwave; Thiazole

Indexed keywords

2 (3Æ,4Æ,5Æ TRIMETHOXY)PHENYL THIAZOLE; ALCOHOL; ANTINEOPLASTIC AGENT; THIAZOLE DERIVATIVE; THIOAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CYCLIZATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MICROWAVE IRRADIATION; PRIORITY JOURNAL; T LYMPHOCYTE; UTERINE CERVIX CARCINOMA;

EID: 35348977707     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018007781788507     Document Type: Article

References (13)

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13. General procedure for the condensation of α-halo ketones and thioamides under microwave conditions. To a 10 mL microwave vial equipped with a magnetic stir bar were added α-halo ketone 3a-f (0.5 mmol) and EtOH (2.5 mL). The appropriate thioamide 4a-e (0.5 mmol) was then added and the vial capped with a rubber septum. The vial was irradiated with microwaves for 1 min at 100°C (Discover, CEM, 2450 MHz, P=250 W). After heating, the vessel was cooled, the precipitate was collected by filtration and washed with ethyl ether or the solvent was evaporated and purified by flash chromatography on silica gel to give the titled compounds.