Antibody responses to deamidated gliadin peptide show high specificity and parallel antibodies to tissue transglutaminase in developing coeliac disease

Clinical and Experimental Immunology

Volumn 150, Issue 2, 2007, Pages 285-293

  Ankelo, M ^a,h   Kleimola, V ^b   Simell, S ^c   Simell, O ^c   Knip, M ^d,e   Jokisalo, E ^a   Tarkia, M ^a   Westerlund, A ^a   He, Q ^f   Viander, M ^c   Ilonen, J ^c,g   Hinkkanen, A E ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b Biofile Ltd   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^g UNIVERSITY OF EASTERN FINLAND   (Finland)

^h PerkinElmer Finland Oy   (Finland)

Author keywords

Antibody; Coeliac disease; Dual label assay; Gliadin peptide; IFMA; Lanthanide; Time resolved fluorometry

Indexed keywords

DEAMIDATED GLIADIN PEPTIDE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LANTHANIDE; PEPTIDE DERIVATIVE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANTIBODY RESPONSE; ARTICLE; BIOTINYLATION; CELIAC DISEASE; CHILD; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INTESTINE BIOPSY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN INTOLERANCE; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; CELIAC DISEASE; CHILD; EPIDEMIOLOGIC METHODS; FLUOROIMMUNOASSAY; GLIADIN; GTP-BINDING PROTEINS; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MIDDLE AGED; PEPTIDE FRAGMENTS; TRANSGLUTAMINASES;

EID: 35348965209     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03487.x     Document Type: Article

References (24)

1. Koning F, Schuppan D, Cerf-Bensussan N, Sollid LM. Pathomechanisms in celiac disease. Best Pract Res Clin Gastroenterol 2005 19 : 373 87.
2. Sollid LM. Molecular basis of celiac disease. Annu Rev Immunol 2000 18 : 53 81.
3. Aleanzi M, Demonte AM, Esper C, Garcilazo S, Waggener M. Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides. Clin Chem 2001 47 : 2023 8.
4. Sjostrom H, Lundin KE, Molberg O et al. Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition. Scand J Immunol 1998 48 : 111 5.
5. Molberg O, McAdam SN, Korner R et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998 4 : 713 7.
6. Qiao SW, Bergseng E, Molberg O, Jung G, Fleckenstein B, Sollid LM. Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation. J Immunol 2005 175 : 254 61.
7. Ivarsson A, Hernell O, Stenlund H, Persson LA. Breast-feeding protects against celiac disease. Am J Clin Nutr 2002 75 : 914 21.
8. Norris JM, Barriga K, Hoffenberg EJ et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA 2005 293 : 2343 51.
9. Dieterich W, Ehnis T, Bauer M et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997 3 : 797 801.
10. Feighery L, Collins C, Feighery C et al. Anti-transglutaminase antibodies and the serological diagnosis of coeliac disease. Br J Biomed Sci 2003 60 : 14 8.
11. Lock RJ, Stevens S, Pitcher MC, Unsworth DJ. Is immunoglobulin A anti-tissue transglutaminase antibody a reliable serological marker of coeliac disease? Eur J Gastroenterol Hepatol 2004 16 : 467 70.
12. van Herpen TW, Goryunova SV, van der Schoot J et al. Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes. BMC Genomics 2006 7 : 1.
13. Schwertz E, Kahlenberg F, Sack U et al. Serologic assay based on gliadin-related nonapeptides as a highly sensitive and specific diagnostic aid in celiac disease. Clin Chem 2004 50 : 2370 5.
14. Osman AA, Gunnel T, Dietl A et al. B cell epitopes of gliadin. Clin Exp Immunol 2000 121 : 248 54.
15. Atkinson MA, Bowman MA, Kao KJ et al. Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N Engl J Medical 1993 329 : 1853 8.
16. Cataldo F, Marino V, Ventura A, Bottaro G, Corazza GR. Prevalence and clinical features of selective immunoglobulin A deficiency in coeliac disease: an Italian multicentre study. Italian Society of Paediatric Gastroenterology and Hepatology (SIGEP) and 'Club del Tenue' Working Groups on Coeliac Disease. Gut 1998 42 : 362 5.
17. Prince HE, Norman GL, Binder WL. Immunoglobulin A (IgA) deficiency and alternative celiac disease-associated antibodies in sera, submitted to a reference laboratory for endomysial IgA testing. Clin Diagn Lab Immunol 2000 7 : 192 6.
18. Sugai E, Vazquez H, Nachman F et al. Accuracy of testing for antibodies to synthetic gliadin-related peptides in celiac disease. Clin Gastroenterol Hepatol 2006 4 : 1112 7.
19. Wasserfall CH, Atkinson MA. Autoantibody markers for the diagnosis and prediction of type 1 diabetes. Autoimmun Rev 2006 5 : 424 8.
20. Korponay-Szabo IR, Dahlbom I, Laurila K et al. Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency. Gut 2003 52 : 1567 71.
21. Kumar V, Jarzabek-Chorzelska M, Sulej J, Karnewska K, Farrell T, Jablonska S. Celiac disease and immunoglobulin a deficiency: how effective are the serological methods of diagnosis? Clin Diagn Lab Immunol 2002 9 : 1295 300.
22. Shan L, Molberg O, Parrot I et al. Structural basis for gluten intolerance in celiac sprue. Science 2002 297 : 2275 9.
23. Simell S, Kupila A, Hoppu S et al. Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility. Scand J Gastroenterol 2005 40 : 1182 91.
24. Bao F, Yu L, Babu S et al. One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease-associated transglutaminase autoantibodies. J Autoimmun 1999 13 : 143 8.