Leptin as a cardiovascular risk factor

Hippokratia

Volumn 11, Issue 4, 2007, Pages 163-170

  Efstratiadis, G ^a,b   Nikolaidou, C ^a   Vergoulas, G ^a  

^a Aristotle University and Hippokration General Hospital   (Greece)

^b NONE   (Greece)

Author keywords

Atherosclerosis; Cardiovascular events; Coronary heart disease; Leptin; Obesity

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

ATHEROSCLEROSIS; BLOOD VESSEL CALCIFICATION; BLOOD VESSEL WALL; BODY MASS; CARDIOVASCULAR RISK; FIBRINOLYSIS; HEART INFARCTION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOREGULATION; ISCHEMIC HEART DISEASE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; ST SEGMENT ELEVATION; T LYMPHOCYTE;

EID: 35348946323     PISSN: 11084189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Faggioni R, Feingold R, Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition.The FASEB Journal 2001; 15: 2565-2571
2. Söderberg S, Olsson T, Eliasson M, et al. Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women. J Int Med 1999; 245: 533
3. Loffreda S, Yang Q, Lin Z, et al. Leptin regulates proinflammatory immune responses.The FASEB Journal 1998; 12: 57-65
4. Parhami F, Tintut Y, Ballard A, et al. Leptin Enhances the Calcification of Vascular Cells. Circulation Research 2001; 88: 954
5. Caro JF, Sinha MK, Kolaczynski JW, et al. Leptin: the tale of an obesity gene. Diabetes 1996; 45: 1455-1462
6. Ioffe E, Moon B, Connolly E, et al. Abnormal regulation of the leptin gene in the pathogenesis of obesity. Proc Natl Acad Sci USA 1998; 95: 11852-11857
7. Bouloumi A, Marumo T, Lafontan M, et al. Leptin induces oxidative stress in human endothelial cells. The FASEB Journal 1999; 13: 1231-1238
8. Constance ER, Everhart JE. Leptin concentrations in the United States: relations with demographic and anthropometric measures. Am J Clin Nutr 2001; 74: 295-301
9. Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature (London) 1996; 382: 250-252
10. Frederich RC, Lollmann B, Hamann A, et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 1995; 96: 1658-1663
11. Coleman DL. Obese and diabetes: two mutant genes causing diabetes - obesity syndromes in mice. Diabetologia 1978; 14: 1-8
12. Söderberg S, Ahrιn B, Jansson H, et al. Leptin is associated with increased risk of myocardial infarction. J Int Med 1999; 246: 409
13. Singhal A, Sadaf Farooqi I, Cole J, et al. Influence of Leptin on Arterial Distensibility. A Novel Link Between Obesity and Cardiovascular Disease. Circulation 2002; 106: 1919
14. Reilly MP, Iqbal N, Schutta M, et al. Plasma Leptin Levels Are Associated with Coronary Atherosclerosis in Type 2 Diabetes.J Clin End & Met 2004; 89: 3872-3878
15. Anderson HC. Molecular biology of matrix vesicles. Clin Orthop 1995; 314: 266-280
16. Narisawa S, Hofmann MC, Ziomek CA, et al. Embryonic alkaline phosphatase is expressed at M-phase in the spermatogenic lineage of the mouse. Development 1992; 116: 159-165
17. Kang SM, Kwon HM, Hong BK, et al. Expression of leptin receptor (Ob-R) in human atherosclerotic lesions: potential role in intimal neovascularization. Yonsei Med J 2000; 41: 68-75
18. Hirai T, Sasayama S, Kawasaki T, et al. Stiffness of systemic arteries in patients with myocardial infarction: a non-invasive method to predict severity of coronary atherosclerosis. Circulation 1989; 80: 78-86
19. Wada T, Kodaira K, Fujishiro K, et al. Correlation of ultrasound-measured common carotid artery stiffness with pathological findings. Arterioscler Thromb 1994; 14: 479-482
20. Toto-Moukouo JJ, Achimastos A, Asmar RG, et al. Pulse wave velocity in patients with obesity and hypertension. Am Heart J 1986; 112: 136-140
21. Tounian P, Aggoun Y, Dubern B, et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 2001; 358: 1400-1404
22. Yamashita T, Sasahara T, Pomeroy SE, et al. Arterial compliance, blood pressure, plasma leptin, and plasma lipids in women are improved with weight reduction equally with a meat-based diet and a plant-based diet. Metabolism 1998; 47: 1308-1314
23. Blacher J, Asmar R, Djane S, et al. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 1999; 33: 1111-1117
24. Vant V, Schols AM. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord 2001; 25: 1759-1766
25. Zhang F, Basinski MB, Beals JM, et al. Crystal structure of the obese protein leptin-E100. Nature (London) 1997; 387: 206-209
26. Baumann H, Morella KK, White DW, et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996; 93: 8374-8378
27. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-1271
28. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leuk Biol 2000; 68: 437-446
29. Gainsford T, Willson TA, Metcalf D, et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564-14568
30. Faggioni R, Fantuzzi G, Gabay C, et al. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 1999; 276: R136-R142
31. Takahashi N, Waelput W, Guisez Y. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 1999; 189: 207-212
32. Juhan-Vague I, Alessi MC. Fibrinolysis and risk of coronary artery disease. Fibrinolysis 1996; 10: 127-136
33. Meade TW, Ruddock V, Stirling Y, et al. Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 1993; 342: 1076-1079
34. Malmberg K, Bεvenholm P, Hamsten A. Clinical and biochemical factors associated with prognosis after myocardial infarction at a young age. J Am Coll Cardiol 1994; 24: 592-599
35. Jansson JH, Olofsson BO, Nilsson TK. Predictive value of tissue plasminogen activator mass concentration on long-term mortality in patients with coronary artery disease. A 7-year follow-up. Circulation 1993; 88: 2030-2034
36. Rao GN, Berk BC. Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression. Circ Res 1992; 70: 593-599
37. Palmer HJ, Paulson KE. Reactive oxygen species and antioxidants in signal transduction and gene expression. Nutr Rev 1997; 55: 353-361
38. Cimino F, Esposito F, Ammendola R, et al. Gene regulation by reactive oxygen species. Curr Top Cell Regul 1997; 35: 123-147
39. Wallace AM, McMahon AD, Packard CJ, et al. Plasma Leptin and the Risk of Cardiovascular Disease in the West of Scotland Coronary Prevention Study (WOSCOPS). Circulation 2001; 104: 3052
40. Taneli F, Yegane S, Ulman C, et al. Increased Serum Concentrations in Patients with Chronic Stable Angina Pectoris and ST-Elevated Myocardial Infarction. Angiology 2006; 57: 267-272