Biocatalytic synthesis of 4-pregnen-20,21-diol-3-one, a selective inhibitor of human 5α-reductase type II

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 22, Issue 5, 2007, Pages 570-576

  Hannemann, Frank ^a   Bernhardt, Rita ^a   Jose, Joachim ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

20 dihydro DOC; Benign prostate hyperplasia; Biocatalysis; Enzyme inhibitor; Human 5 reductase

Indexed keywords

4 PREGNEN 20,21 DIOL 3 ONE; AROMATASE; CYTOCHROME P450 17; DEOXYCORTICOSTERONE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM ISOLATE; CATALYSIS; CELL CULTURE; CONTROLLED STUDY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; SUPERNATANT;

CELLS, CULTURED; CHOLESTENONE 5 ALPHA-REDUCTASE; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; HYDROXYPROGESTERONES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE;

EID: 35348935565     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360701425311     Document Type: Article

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