Novel C2-purine position analogs of nitrobenzylmercaptopurine riboside as human equilibrative nucleoside transporter 1 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 24, 2007, Pages 7726-7737

  Gupte, Amol ^a   Buolamwini, John K ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Analogs; Binding affinity; Equilibrative nucleoside transporter 1; Flow cytometry; Nitrobenzylmercaptopurine riboside (NBMPR); Nucleoside transporter inhibitors; Structure activity relationship (SAR); Synthesis

Indexed keywords

2 ACETAMIDO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 AMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 BENZAMIDO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 BENZYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 BROMO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 BUTYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 CHLORO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 CYCLOBUTYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 CYCLOHEXYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 CYCLOPENTYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 CYCLOPROPYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 DIETHANOLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 DIMETHYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 ETHYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 FLUORO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 IODO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 METHYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 MONOETHANOLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 PENTYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 PHENETHYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; 2 PROPYLAMINO 6 (4 NITROBENZYLTHIO) 9 BETA DEXTRO RIBOFURANOSYLPURINE; NITROBENZYLMERCAPTOPURINE RIBOSIDE DERIVATIVE; NITROBENZYLTHIOINOSINE; NUCLEOSIDE TRANSPORTER 1 INHIBITOR; PROTEIN INHIBITOR; PURINE DERIVATIVE; UNCLASSIFIED DRUG; 2 FLUORO 4 NITROBENZYL MERCAPTOPURINE RIBOSIDE; 2-FLUORO-4-NITROBENZYL MERCAPTOPURINE RIBOSIDE; 4-NITROBENZYLTHIOINOSINE; DRUG DERIVATIVE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; MERCAPTOPURINE RIBOSIDE;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIGAND BINDING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING;

CELL LINE; DRUG EVALUATION, PRECLINICAL; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FLOW CYTOMETRY; HUMANS; MOLECULAR STRUCTURE; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOINOSINE;

EID: 35348915552     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.058     Document Type: Article

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