Synthesis and flow cytometric evaluation of novel 1,2,3,4-tetrahydroisoquinoline conformationally constrained analogues of nitrobenzylmercaptopurine riboside (NBMPR) designed for probing its conformation when bound to the es nucleoside transporter

Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2003, Pages 831-837

  Zhu, Zhengxiang ^a   Furr, John ^b   Buolamwini, John K ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITROBENZYLTHIOINOSINE; TETRAHYDROISOQUINOLINE;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; FLOW CYTOMETRY; ISOMER; NUCLEOSIDE TRANSPORT; REACTION ANALYSIS; SYNTHESIS;

EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; FLOW CYTOMETRY; HUMANS; ISOQUINOLINES; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIOINOSINE; TUMOR CELLS, CULTURED;

EID: 0037468525     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020405p     Document Type: Article

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