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Volumn 20, Issue 3, 2004, Pages 208-220

Progresses in the pharmacological treatment of pulmonary arterial hypertension;Progresos en el tratamiento farmacológico de la hipertensión arterial pulmonar

Author keywords

Pharmacological treatment; Pulmonary arterial hypertension

Indexed keywords

BOSENTAN; DILTIAZEM; ILOPROST; NIFEDIPINE; NITRIC OXIDE; PROSTACYCLIN; SILDENAFIL; SITAXSENTAN; UNIPROST; WARFARIN;

EID: 35348906690     PISSN: 01864866     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (51)
  • 2
    • 0034727717 scopus 로고    scopus 로고
    • Primary pulmonary hypertension: A vascular biology and translational research "work in progress
    • Archer S, Rich S. Primary pulmonary hypertension: a vascular biology and translational research "work in progress". Circulation 2000;102:2781-91.
    • (2000) Circulation , vol.102 , pp. 2781-2791
    • Archer, S.1    Rich, S.2
  • 3
    • 0031031440 scopus 로고    scopus 로고
    • Primary pulmonary hypertension
    • Rubin LJ. Primary pulmonary hypertension. N Engl J Med 1997;336:111-7.
    • (1997) N Engl J Med , vol.336 , pp. 111-117
    • Rubin, L.J.1
  • 4
    • 0042469293 scopus 로고    scopus 로고
    • ¿Qué es lo nuevo en el tratamiento de la hipertensión arterial pulmonar?
    • Pulido T. ¿Qué es lo nuevo en el tratamiento de la hipertensión arterial pulmonar? Arch Cardiol Mex 2003;73:S121-4.
    • (2003) Arch Cardiol Mex , vol.73
    • Pulido, T.1
  • 5
    • 0034868447 scopus 로고    scopus 로고
    • Recommendations on the management of pulmonary hypertension in clinical practice
    • British Thoracic Society Guidelines and Medical Practice Committee
    • British Thoracic Society Guidelines and Medical Practice Committee. Recommendations on the management of pulmonary hypertension in clinical practice. Heart 2001;86:S1-13.
    • (2001) Heart , vol.86
  • 6
    • 0037163478 scopus 로고    scopus 로고
    • Pulmonary hypertension: Hemodynamic diagnosis and management
    • Chatterjee K, De Marco T, Alpert JS. Pulmonary hypertension: hemodynamic diagnosis and management. Arch Intern Med 2002;162:1925-33.
    • (2002) Arch Intern Med , vol.162 , pp. 1925-1933
    • Chatterjee, K.1    De Marco, T.2    Alpert, J.S.3
  • 7
    • 0035543338 scopus 로고    scopus 로고
    • Cellular pathophysiology and therapy of pulmonary hypertension
    • Olschewski H, Rose F, Grunig E, Ghofrani A, et al. Cellular pathophysiology and therapy of pulmonary hypertension. J Lab Clin Med 2001;138:367-77.
    • (2001) J Lab Clin Med , vol.138 , pp. 367-377
    • Olschewski, H.1    Rose, F.2    Grunig, E.3    Ghofrani, A.4
  • 9
    • 0031690521 scopus 로고    scopus 로고
    • Nitric oxide and endothelin-1 in pulmonary arterial hypertension
    • Giaid A. Nitric oxide and endothelin-1 in pulmonary arterial hypertension. Chest 1998;114:S208-12.
    • (1998) Chest , vol.114
    • Giaid, A.1
  • 10
    • 0029055964 scopus 로고
    • Reduced expression of the endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
    • Giaid A, Saleh D. Reduced expression of the endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995;333:214-21.
    • (1995) N Engl J Med , vol.333 , pp. 214-221
    • Giaid, A.1    Saleh, D.2
  • 11
    • 0033032949 scopus 로고    scopus 로고
    • Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary arterial hypertension
    • Tuder RM, Cool CD, Gearci MW, Wang J, et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary arterial hypertension. Am J Respir Crit Care Med 1999;159:1925-32.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 1925-1932
    • Tuder, R.M.1    Cool, C.D.2    Gearci, M.W.3    Wang, J.4
  • 12
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary arterial hypertension
    • Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, et al. Expression of endothelin-1 in the lungs of patients with pulmonary arterial hypertension. N Engl J Med 1993;328:1732-9.
    • (1993) N Engl J Med , vol.328 , pp. 1732-1739
    • Giaid, A.1    Yanagisawa, M.2    Langleben, D.3    Michel, R.P.4    Levy, R.5
  • 13
    • 0035797529 scopus 로고    scopus 로고
    • Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred
    • Newman JH, Wheeler L, Lane KB, Loyd E, et al. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N Engl J Med 2001;345:319-24.
    • (2001) N Engl J Med , vol.345 , pp. 319-324
    • Newman, J.H.1    Wheeler, L.2    Lane, K.B.3    Loyd, E.4
  • 14
    • 0033838125 scopus 로고    scopus 로고
    • Familial primary pulmonary hypertension (gene PPH-1) is caused by mutations in the bone morphogenetic protein receptor II gene
    • Deng Z, Morse JH, Slager S, Cuervo N, et al. Familial primary pulmonary hypertension (gene PPH-1) is caused by mutations in the bone morphogenetic protein receptor II gene. Am J Hum Genet 2000;67:737-44.
    • (2000) Am J Hum Genet , vol.67 , pp. 737-744
    • Deng, Z.1    Morse, J.H.2    Slager, S.3    Cuervo, N.4
  • 15
    • 0034904703 scopus 로고    scopus 로고
    • Severe pulmonary hypertension after the discovery of the familial primary pulmonary hypertension gene
    • Tuder RM, Yeager ME, Geraci MW, Golpon HA, et al. Severe pulmonary hypertension after the discovery of the familial primary pulmonary hypertension gene. Eur Respir J 2001;17:1065-9.
    • (2001) Eur Respir J , vol.17 , pp. 1065-1069
    • Tuder, R.M.1    Yeager, M.E.2    Geraci, M.W.3    Golpon, H.A.4
  • 16
    • 0035859940 scopus 로고    scopus 로고
    • Altered growth response of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor beta-1 and bone morphogenetic proteins
    • Morrell NW, Yang X, Upton PD, Jourdan KB, et al. Altered growth response of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor beta-1 and bone morphogenetic proteins. Circulation 2001;104:790-5.
    • (2001) Circulation , vol.104 , pp. 790-795
    • Morrell, N.W.1    Yang, X.2    Upton, P.D.3    Jourdan, K.B.4
  • 17
    • 0035910729 scopus 로고    scopus 로고
    • Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in pulmonary arterial hypertension
    • Yeager M, Halley GR, Golpon HA, Voelkel NF, et al. Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in pulmonary arterial hypertension. Circ Res 2001;88:E2-11.
    • (2001) Circ Res , vol.88
    • Yeager, M.1    Halley, G.R.2    Golpon, H.A.3    Voelkel, N.F.4
  • 18
    • 0032491187 scopus 로고    scopus 로고
    • Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with pulmonary arterial hypertension
    • Yuan JX, Aldinger AM, Juhaszova M, Wang J, et al. Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with pulmonary arterial hypertension. Circulation 1998;98:1400-6.
    • (1998) Circulation , vol.98 , pp. 1400-1406
    • Yuan, J.X.1    Aldinger, A.M.2    Juhaszova, M.3    Wang, J.4
  • 19
    • 0034778907 scopus 로고    scopus 로고
    • Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension
    • Rabinovitch M. Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension. J Clin Invest 2001;108:1109-11.
    • (2001) J Clin Invest , vol.108 , pp. 1109-1111
    • Rabinovitch, M.1
  • 20
    • 2342607060 scopus 로고    scopus 로고
    • Treatments and strategies to optimize the comprehensive management of patients with pulmonary arterial hypertension
    • Gildea TR, Arroliga AC, Minai OA. Treatments and strategies to optimize the comprehensive management of patients with pulmonary arterial hypertension. Clev Clin J Med 2003;70:S18-27.
    • (2003) Clev Clin J Med , vol.70
    • Gildea, T.R.1    Arroliga, A.C.2    Minai, O.A.3
  • 21
    • 0031765160 scopus 로고    scopus 로고
    • A survey of diagnostic practices and the use of epoprostenol in patients with primary pulmonary hypertension
    • Robbins IM, Christman BW, Newman JH, et al. A survey of diagnostic practices and the use of epoprostenol in patients with primary pulmonary hypertension. Chest 1998;114:1269-75.
    • (1998) Chest , vol.114 , pp. 1269-1275
    • Robbins, I.M.1    Christman, B.W.2    Newman, J.H.3
  • 22
    • 0026632785 scopus 로고
    • The effect of high doses of calcium channel blockers on survival in primary pulmonary hypertension
    • Rich S, Kaufmann E, Levy PS. The effect of high doses of calcium channel blockers on survival in primary pulmonary hypertension. N Engl J Med 1992;327:76-81.
    • (1992) N Engl J Med , vol.327 , pp. 76-81
    • Rich, S.1    Kaufmann, E.2    Levy, P.S.3
  • 23
    • 0023238042 scopus 로고
    • High dose calcium channel blocking therapy for primary pulmonary hypertension: Evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy
    • Rich S, Brundage BH. High dose calcium channel blocking therapy for primary pulmonary hypertension: evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy. Circulation 1987;76:135-41.
    • (1987) Circulation , vol.76 , pp. 135-141
    • Rich, S.1    Brundage, B.H.2
  • 24
    • 0030031888 scopus 로고    scopus 로고
    • A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The primary pulmonary hypertension study group
    • Barst RJ, Rubin LJ, Long WA, McGoon MD, Rich S, Badesch DB, et al. A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The primary pulmonary hypertension study group. N Engl J Med 1996;334:296-301.
    • (1996) N Engl J Med , vol.334 , pp. 296-301
    • Barst, R.J.1    Rubin, L.J.2    Long, W.A.3    McGoon, M.D.4    Rich, S.5    Badesch, D.B.6
  • 25
    • 4243212673 scopus 로고    scopus 로고
    • Optimal dosage range of prostacyclin for patients with primary pulmonary hypertension
    • McLaughlin VV, Meyer PM, Rich S. Optimal dosage range of prostacyclin for patients with primary pulmonary hypertension. Am J Respir Crit Care Med 2000;161:A458.
    • (2000) Am J Respir Crit Care Med , vol.161
    • McLaughlin, V.V.1    Meyer, P.M.2    Rich, S.3
  • 26
    • 0032576672 scopus 로고    scopus 로고
    • Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension
    • McLaughlin VV, Genthner DE, Panella MM, Rich S. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. N Engl J Med 1998;338:273-7.
    • (1998) N Engl J Med , vol.338 , pp. 273-277
    • McLaughlin, V.V.1    Genthner, D.E.2    Panella, M.M.3    Rich, S.4
  • 27
    • 0037126044 scopus 로고    scopus 로고
    • Survival in primary pulmonary hypertension: The impact of epoprostenol therapy
    • McLaughlin VV, Shillington A, Rich S. Survival in primary pulmonary hypertension: the impact of epoprostenol therapy. Circulation 2002;106:1477-82.
    • (2002) Circulation , vol.106 , pp. 1477-1482
    • McLaughlin, V.V.1    Shillington, A.2    Rich, S.3
  • 28
    • 0037086133 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: A double blind randomized controlled trial
    • Simmoneau G, Barst RJ, Galie N, Naejie R, Rich S, Bourge RC, et al. Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double blind randomized controlled trial. Am J Respir Crit Care Med 2002;165:800-4.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 800-804
    • Simmoneau, G.1    Barst, R.J.2    Galie, N.3    Naejie, R.4    Rich, S.5    Bourge, R.C.6
  • 29
    • 0034696634 scopus 로고    scopus 로고
    • Inhaled iloprost to treat severe pulmonary hypertension: An uncontrolled trial
    • Olschewski H, Ghofrani HA, Schmehl T, Winkler J, et al. Inhaled iloprost to treat severe pulmonary hypertension: an uncontrolled trial. Ann Intern Med 2000;132:435-43.
    • (2000) Ann Intern Med , vol.132 , pp. 435-443
    • Olschewski, H.1    Ghofrani, H.A.2    Schmehl, T.3    Winkler, J.4
  • 30
    • 0033977505 scopus 로고    scopus 로고
    • A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolised iloprost in primary pulmonary hypertension
    • Hoeper MM, Olschewski H, Ghofrani HA, Wilkens H, Winkler J, et al. A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolised iloprost in primary pulmonary hypertension. J Am Coll Cardiol 2000;35:176-82.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 176-182
    • Hoeper, M.M.1    Olschewski, H.2    Ghofrani, H.A.3    Wilkens, H.4    Winkler, J.5
  • 32
    • 3042686863 scopus 로고    scopus 로고
    • Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension
    • Nagaya N, Uematsu M, Okano Y, Kyotani S, et al. Effect of orally active prostacyclin analogue on survival of outpatients with primary pulmonary hypertension. J Am Coll Cardiol 1999;34:1188-92.
    • (1999) J Am Coll Cardiol , vol.34 , pp. 1188-1192
    • Nagaya, N.1    Uematsu, M.2    Okano, Y.3    Kyotani, S.4
  • 33
    • 0036569119 scopus 로고    scopus 로고
    • Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: A randomized, double-blind, placebo-controlled trial
    • Galie N, Humbert M, Vachiery JL, Vizza CD, Kneussl M, Manes A, et al. Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. J Am Coll Cardiol 2002;39:1496-502.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 1496-1502
    • Galie, N.1    Humbert, M.2    Vachiery, J.L.3    Vizza, C.D.4    Kneussl, M.5    Manes, A.6
  • 35
    • 0029116310 scopus 로고    scopus 로고
    • Levin ER. Endothelins. In: Epstein FH, editor. Mechanisms of disease. N Engl J Med 1995;333:356-62.
    • Levin ER. Endothelins. In: Epstein FH, editor. Mechanisms of disease. N Engl J Med 1995;333:356-62.
  • 36
    • 0242330203 scopus 로고    scopus 로고
    • Endothelin receptor blockers in cardiovascular disease
    • Rich S, McLaughlin VV. Endothelin receptor blockers in cardiovascular disease. Circulation 2003;108:2184-90.
    • (2003) Circulation , vol.108 , pp. 2184-2190
    • Rich, S.1    McLaughlin, V.V.2
  • 37
    • 0033529389 scopus 로고    scopus 로고
    • Endothelin-1 potentiates human smooth muscle cell growth to PDGF: Effects of ET-A and ET-B receptor blockade
    • Yang Z, Krasniei N, Luschner TF. Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ET-A and ET-B receptor blockade. Circulation 1999;100:5-8.
    • (1999) Circulation , vol.100 , pp. 5-8
    • Yang, Z.1    Krasniei, N.2    Luschner, T.F.3
  • 39
    • 0038374932 scopus 로고    scopus 로고
    • Drug highlight: Bosentan
    • Cheng JWM. Drug highlight: Bosentan. Heart Dis 2003;5:161-9.
    • (2003) Heart Dis , vol.5 , pp. 161-169
    • Cheng, J.W.M.1
  • 40
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: A randomized placebo-controlled study
    • Channick RN, Simonneau G, Sitbon O, Robbins I, Frost A, Tapson VF, et al. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a randomized placebo-controlled study. Lancet 2001;358:1119-23.
    • (2001) Lancet , vol.358 , pp. 1119-1123
    • Channick, R.N.1    Simonneau, G.2    Sitbon, O.3    Robbins, I.4    Frost, A.5    Tapson, V.F.6
  • 42
    • 0037484589 scopus 로고    scopus 로고
    • Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: A 1 year follow up study
    • Sitbon O, Badesch DB, Channick RN, Frost A, Robbins IM, et al. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1 year follow up study. Chest 2003;124:247-54.
    • (2003) Chest , vol.124 , pp. 247-254
    • Sitbon, O.1    Badesch, D.B.2    Channick, R.N.3    Frost, A.4    Robbins, I.M.5
  • 43
    • 0041782976 scopus 로고    scopus 로고
    • Safety and efficacy of bosentan combined with epoprostenol in patients with severe pulmonary arterial hypertension
    • Humbert M, Barst RJ, Robbins IM, et al. Safety and efficacy of bosentan combined with epoprostenol in patients with severe pulmonary arterial hypertension. Am J Respir Crit Care Med 2003;167:A441.
    • (2003) Am J Respir Crit Care Med , vol.167
    • Humbert, M.1    Barst, R.J.2    Robbins, I.M.3
  • 44
    • 0036283401 scopus 로고    scopus 로고
    • Clinical efficacy of sitaxsentan, an oral endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension
    • Barst RJ, Rich S, Widlitz A, et al. Clinical efficacy of sitaxsentan, an oral endothelin-A receptor antagonist, in patients with pulmonary arterial hypertension. Chest 2002;121:1860-8.
    • (2002) Chest , vol.121 , pp. 1860-1868
    • Barst, R.J.1    Rich, S.2    Widlitz, A.3
  • 45
    • 0242324585 scopus 로고    scopus 로고
    • Sitaxsentan, a selective ET-a antagonist improves cardiopulmonary hemodynamics in pulmonary arterial hypertension
    • Barst RJ, Langleben D, Frost A, et al. Sitaxsentan, a selective ET-a antagonist improves cardiopulmonary hemodynamics in pulmonary arterial hypertension. Am J Respir Crit Care Med 2003;167:A273.
    • (2003) Am J Respir Crit Care Med , vol.167
    • Barst, R.J.1    Langleben, D.2    Frost, A.3
  • 46
    • 85101730406 scopus 로고    scopus 로고
    • Pulmonary hypertension and the search for the selective pulmonary vasodilator (commentary)
    • Dweik RA. Pulmonary hypertension and the search for the selective pulmonary vasodilator (commentary). Lancet 2002;360:286-7.
    • (2002) Lancet , vol.360 , pp. 286-287
    • Dweik, R.A.1
  • 47
    • 0033547738 scopus 로고    scopus 로고
    • Use of sildenafil (viagra) in patients with cardiovascular disease
    • Cheitlin MD, Hutter AM, Brindis RG, Ganz P, Kaul S, et al. Use of sildenafil (viagra) in patients with cardiovascular disease. Circulation 1999;99:168-77.
    • (1999) Circulation , vol.99 , pp. 168-177
    • Cheitlin, M.D.1    Hutter, A.M.2    Brindis, R.G.3    Ganz, P.4    Kaul, S.5
  • 48
    • 0035845634 scopus 로고    scopus 로고
    • Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension
    • Wilkens H, Guth A, Koenig J, Forestier N, Cremers B, et al. Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension. Circulation 2001;104:1218-22.
    • (2001) Circulation , vol.104 , pp. 1218-1222
    • Wilkens, H.1    Guth, A.2    Koenig, J.3    Forestier, N.4    Cremers, B.5
  • 49
    • 0037150158 scopus 로고    scopus 로고
    • Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: Comparison with inhaled nitric oxide
    • Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto K, Archer S. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation 2002;105:2398-403.
    • (2002) Circulation , vol.105 , pp. 2398-2403
    • Michelakis, E.1    Tymchak, W.2    Lien, D.3    Webster, L.4    Hashimoto, K.5    Archer, S.6
  • 51
    • 0242349756 scopus 로고    scopus 로고
    • Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension
    • Michelakis ED, Tymchak W, Noga M, Webster L, Chen Wu X, Lien D, et al. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation 2003;108:2066-9.
    • (2003) Circulation , vol.108 , pp. 2066-2069
    • Michelakis, E.D.1    Tymchak, W.2    Noga, M.3    Webster, L.4    Chen, W.X.5    Lien, D.6


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